[目的]探讨术后复发三阴性乳腺癌(triple-negative breast cancer,TNBC)临床流行病学特征。[方法]本研究是一项基于医院的、全国多中心、3年(2012—2014年)临床流行病学回顾性研究。纳入术后复发乳腺癌患者病例资料,收集并分析其人口统...[目的]探讨术后复发三阴性乳腺癌(triple-negative breast cancer,TNBC)临床流行病学特征。[方法]本研究是一项基于医院的、全国多中心、3年(2012—2014年)临床流行病学回顾性研究。纳入术后复发乳腺癌患者病例资料,收集并分析其人口统计学信息、潜在危险因素、临床诊疗特点及预后信息。[结果]共纳入术后复发TNBC患者455例,平均年龄46岁,中位无病生存时间20个月。相较非TNBC,TNBC在无病生存时间、肝转移、肺转移、骨转移、辅助化疗和分布地区上均有统计学差异(P均<0.05)。多因素分析显示,淋巴结转移数目大于2(OR=0.817,95%CI:0.678~0.985,P=0.034)和新辅助化疗未达病理完全缓解(OR=0.757,95%CI:0.609~0.942,P=0.012)是术后复发TNBC无病生存时间的独立影响因素。[结论]淋巴结转移数大于2和新辅助化疗未达病理完全缓解的TNBC患者,术后应进行密切随访。展开更多
Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Ch...Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Chinese rural population. Methods All participants of a previously reported prevalent study were interviewed using CCQ. The participants who answered yes to at least one item on CCQ were defined as positive. The Parkinson＇s disease （PD） diagnosis was established using United Kingdom Parkinson＇s disease Brain Bank Clinical diagnosis criteria （UKPDBBC） and served as a gold standard to determine the sensitivity, specificity, and positive and negative predictive values （PPV, NPV） for the questionnaire. Results Among 16 130 participants, 2872 （17.8%） were screened positive for CCQ and 13 258 negative （82.2%）. Among the 697 participants diagnosed as having Parkinson syndrome, 605 were positive for CCQ, and 92 were negative, leading to a sensitivity of 86.8%. Out of the 15 433 non-Parkinson syndrome participants, 13 166 were negative to CCQ, giving a specificity of 85.3%. Among the 2872 participants screened positive, 605 were diagnosed with Parkinson syndrome, and their PPV was 21.1%. For the 13 258 participants screened negative on CCQ, 92 were diagnosed with Parkinson syndrome and 13 166 did not have Parkinson syndrome, leading to a NPV of 99.3%. Conclusions CCQ appeared to have satisfactory statistical parameters to serve as a screening instrument for Parkinson syndrome in this rural Chinese population. Further studies may prove the utility of this short questionnaire in Parkinson syndrome screening among Chinese populations including those residing in rural areas.展开更多
文摘[目的]探讨术后复发三阴性乳腺癌(triple-negative breast cancer,TNBC)临床流行病学特征。[方法]本研究是一项基于医院的、全国多中心、3年(2012—2014年)临床流行病学回顾性研究。纳入术后复发乳腺癌患者病例资料,收集并分析其人口统计学信息、潜在危险因素、临床诊疗特点及预后信息。[结果]共纳入术后复发TNBC患者455例,平均年龄46岁,中位无病生存时间20个月。相较非TNBC,TNBC在无病生存时间、肝转移、肺转移、骨转移、辅助化疗和分布地区上均有统计学差异(P均<0.05)。多因素分析显示,淋巴结转移数目大于2(OR=0.817,95%CI:0.678~0.985,P=0.034)和新辅助化疗未达病理完全缓解(OR=0.757,95%CI:0.609~0.942,P=0.012)是术后复发TNBC无病生存时间的独立影响因素。[结论]淋巴结转移数大于2和新辅助化疗未达病理完全缓解的TNBC患者,术后应进行密切随访。
文摘Background Standardized screening tools for Parkinson syndrome have not been developed for non-westem populations. This study aimed to validate the Copiah County questionnaire （CCQ） as a screening instrument in a Chinese rural population. Methods All participants of a previously reported prevalent study were interviewed using CCQ. The participants who answered yes to at least one item on CCQ were defined as positive. The Parkinson＇s disease （PD） diagnosis was established using United Kingdom Parkinson＇s disease Brain Bank Clinical diagnosis criteria （UKPDBBC） and served as a gold standard to determine the sensitivity, specificity, and positive and negative predictive values （PPV, NPV） for the questionnaire. Results Among 16 130 participants, 2872 （17.8%） were screened positive for CCQ and 13 258 negative （82.2%）. Among the 697 participants diagnosed as having Parkinson syndrome, 605 were positive for CCQ, and 92 were negative, leading to a sensitivity of 86.8%. Out of the 15 433 non-Parkinson syndrome participants, 13 166 were negative to CCQ, giving a specificity of 85.3%. Among the 2872 participants screened positive, 605 were diagnosed with Parkinson syndrome, and their PPV was 21.1%. For the 13 258 participants screened negative on CCQ, 92 were diagnosed with Parkinson syndrome and 13 166 did not have Parkinson syndrome, leading to a NPV of 99.3%. Conclusions CCQ appeared to have satisfactory statistical parameters to serve as a screening instrument for Parkinson syndrome in this rural Chinese population. Further studies may prove the utility of this short questionnaire in Parkinson syndrome screening among Chinese populations including those residing in rural areas.
