目的探讨脑小血管病(CSVD)患者病程进展与血管内皮功能障碍(ED)因子[同型半胱氨酸(Hcy)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和C反应蛋白(CRP)]表达水平的相关性.方法选取2016年6月至2017年9月在我科诊断为CSVD的患者60例作为...目的探讨脑小血管病(CSVD)患者病程进展与血管内皮功能障碍(ED)因子[同型半胱氨酸(Hcy)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和C反应蛋白(CRP)]表达水平的相关性.方法选取2016年6月至2017年9月在我科诊断为CSVD的患者60例作为研究对象,所有患者均进行了头颅MRI检查.采集外周血,利用ELISA检测与血管内皮功能障碍相关因子Hcy、TNF-α、IL-6和CRP的表达水平.对所纳入患者进行1年时间的随访,随访期内均进行头颅MRI检查.根据随访观察结果,将所纳入患者分为进展组和无进展组,比较两组患者血清Hcy、TNF-α、IL-6和CRP表达水平的差异,并分析它们与CSVD进展的相关性.结果在60例患者中,病程进展的有38例,病程无进展的有22例.与病程无进展组相比,病程进展组患者血清Hcy(17.62+7.23 VS 11.35±5.41,P=0.007)和IL-6(17.46±6.97 VS8.48士4.67,P=0.001)的表达水平高;TNF-α和CRP的表达水平在两组间无差异.经Spearman等级相关分析发现,CSVD患者的病程进展与血清Hcy(r=0.587,P=0.015)和IL-6(r=0.644,P=0.009)的表达水平存在相关性;而与TNF-α和CRP的表达水平不存在相关性.结论CSVD患者血清中血管内皮功能障碍因子Hcy、IL-6的表达水平与病程进展存在相关性,检测这些因子的表达对于判断病情预后具有一定参考意义.展开更多
The violation of monotonicity on reliability measures(RMs)usually makes the mathematical programming algorithms less efficient in solving the reliability-based user equilibrium(RUE)problem.The swapping algorithms prov...The violation of monotonicity on reliability measures(RMs)usually makes the mathematical programming algorithms less efficient in solving the reliability-based user equilibrium(RUE)problem.The swapping algorithms provide a simple and convenient alternative to search traffic equilibrium since they are derivative-free and require weaker monotonicity.However,the existing swapping algorithms are usually based on linear swapping processes which cannot naturally avoid overswapping,and the step-size parameter update methods do not take the swapping feature into account.In this paper,we suggest a self-regulating pairwise swapping algorithm(SRPSA)to search RUE.SRPSA comprises an RM-based pairwise swapping process(RMPSP),a parameter self-diminishing operator and a termination criterion.SRPSA does not need to check the feasibility of either solutions or step-size parameter.It is suggested from the numerical analyses that SRPSA is effective and can swap to the quasi-RUE very fast.Therefore,SRPSA offers a good approach to generate initial points for those superior local search algorithms.展开更多
文摘目的探讨脑小血管病(CSVD)患者病程进展与血管内皮功能障碍(ED)因子[同型半胱氨酸(Hcy)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和C反应蛋白(CRP)]表达水平的相关性.方法选取2016年6月至2017年9月在我科诊断为CSVD的患者60例作为研究对象,所有患者均进行了头颅MRI检查.采集外周血,利用ELISA检测与血管内皮功能障碍相关因子Hcy、TNF-α、IL-6和CRP的表达水平.对所纳入患者进行1年时间的随访,随访期内均进行头颅MRI检查.根据随访观察结果,将所纳入患者分为进展组和无进展组,比较两组患者血清Hcy、TNF-α、IL-6和CRP表达水平的差异,并分析它们与CSVD进展的相关性.结果在60例患者中,病程进展的有38例,病程无进展的有22例.与病程无进展组相比,病程进展组患者血清Hcy(17.62+7.23 VS 11.35±5.41,P=0.007)和IL-6(17.46±6.97 VS8.48士4.67,P=0.001)的表达水平高;TNF-α和CRP的表达水平在两组间无差异.经Spearman等级相关分析发现,CSVD患者的病程进展与血清Hcy(r=0.587,P=0.015)和IL-6(r=0.644,P=0.009)的表达水平存在相关性;而与TNF-α和CRP的表达水平不存在相关性.结论CSVD患者血清中血管内皮功能障碍因子Hcy、IL-6的表达水平与病程进展存在相关性,检测这些因子的表达对于判断病情预后具有一定参考意义.
基金Supported by National Natural Science Foundation of China（60974052） Program for Changjiang Scholars and Innovative Research Team in University （IRT0949） Beijing Jiaotong University Research Program （RCS2008ZT002 2009JBZ001 2009RC008）
基金Projects(71601015,71501013,71471014)supported by the National Natural Science Foundation of ChinaProject(2015JBM060)supported by the Fundamental Research Funds for the Central Universities,China
文摘The violation of monotonicity on reliability measures(RMs)usually makes the mathematical programming algorithms less efficient in solving the reliability-based user equilibrium(RUE)problem.The swapping algorithms provide a simple and convenient alternative to search traffic equilibrium since they are derivative-free and require weaker monotonicity.However,the existing swapping algorithms are usually based on linear swapping processes which cannot naturally avoid overswapping,and the step-size parameter update methods do not take the swapping feature into account.In this paper,we suggest a self-regulating pairwise swapping algorithm(SRPSA)to search RUE.SRPSA comprises an RM-based pairwise swapping process(RMPSP),a parameter self-diminishing operator and a termination criterion.SRPSA does not need to check the feasibility of either solutions or step-size parameter.It is suggested from the numerical analyses that SRPSA is effective and can swap to the quasi-RUE very fast.Therefore,SRPSA offers a good approach to generate initial points for those superior local search algorithms.
