一般的量子图像加密算法虽然能达到加密效果,但需要的量子比特数较多,计算复杂度较高,为优化这一问题,提出了一种位平面分解的量子彩色图像加密方案。首先,采用一种位平面序信息单独编码的彩色数字图像量子表示模型(quantum representat...一般的量子图像加密算法虽然能达到加密效果,但需要的量子比特数较多,计算复杂度较高,为优化这一问题,提出了一种位平面分解的量子彩色图像加密方案。首先,采用一种位平面序信息单独编码的彩色数字图像量子表示模型(quantum representation model of color digital image,QRCI)来表示图像,利用量子交换门设计一种量子位交换操作,并作用于彩色图像中,对图像像素进行置乱,同时再对图像进行颜色通道交换操作。其次,对位平面序列进行反序操作,进一步加强置乱效果。接着,利用安全散列算法(secure hash algorithm 256,SHA-256)产生的哈希值来确定混沌系统的初始值。最后,利用混沌系统产生的序列对图像进行扩散,完成加密过程,形成加密图像。数值分析表明,相较于以往的加密方案,此方案大大降低了彩色图像存储时所需的量子比特位数,同时其密钥空间大,灵敏度高。仿真结果表明,该方案加密效果好,能抵御大部分常见的攻击。展开更多
BACKGROUND The measurement of triceps skinfold(TSF)thickness serves as a noninvasive metric for evaluating subcutaneous fat distribution.Despite its clinical utility,the TSF thickness trajectories and their correlatio...BACKGROUND The measurement of triceps skinfold(TSF)thickness serves as a noninvasive metric for evaluating subcutaneous fat distribution.Despite its clinical utility,the TSF thickness trajectories and their correlation with overall mortality have not been thoroughly investigated.AIM To explore TSF thickness trajectories of Chinese adults and to examine their associations with all-cause mortality.METHODS This study encompassed a cohort of 14747 adults sourced from the China Health and Nutrition Survey.Latent class trajectory modeling was employed to identify distinct trajectories of TSF thickness.Subjects were classified into subgroups reflective of their respective TSF thickness trajectory.We utilized multivariate Cox regression analyses and mediation examinations to explore the link between TSF thickness trajectory and overall mortality,including contributory factors.RESULTS Upon adjustment for multiple confounding factors,we discerned that males in the‘Class 2:Thin-stable’and‘Class 3:Thin-moderate’TSF thickness trajectories exhibited a markedly reduced risk of mortality from all causes in comparison to the‘Class 1:Extremely thin’subgroup.In the mediation analyses,the Geriatric Nutritional Risk Index was found to be a partial intermediary in the relationship between TSF thickness trajectories and mortality.For females,a lower TSF thickness pattern was significantly predictive of elevated all-cause mortality risk exclusively within the non-elderly cohort.CONCLUSION In males and non-elderly females,lower TSF thickness trajectories are significantly predictive of heightened mortality risk,independent of single-point TSF thickness,body mass index,and waist circumference.展开更多
BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)therapy.AI...BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)therapy.AIM To evaluate the risk of infection in patients with T2DM treated with dipeptidyl-peptidase 4(DPP-4)inhibitors.METHODS Electronic databases were searched.The selection criteria included randomized controlled trials focused on cardiovascular outcomes.In these studies,the effects of DPP-4 inhibitors were directly compared to those of either other active anti-diabetic treatments or placebo.Six trials involving 53616 patients were deemed eligible.We calculated aggregate relative risks employing both random-effects and fixed-effects approaches,contingent upon the context.RESULTS The application of DPP-4 inhibitors showed no significant link to the overall infection risk[0.98(0.95,1.02)]or the risk of serious infections[0.96(0.85,1.08)],additionally,no significant associations were found with opportunistic infections[0.69(0.46,1.04)],site-specific infections[respiratory infection 0.99(0.96,1.03),urinary tract infections 1.02(0.95,1.10),abdominal and gastrointestinal infections 1.02(0.83,1.25),skin structure and soft tissue infections 0.81(0.60,1.09),bone infections 0.96(0.68,1.36),and bloodstream infections 0.97(0.80,1.18)].CONCLUSION This meta-analysis of data from cardiovascular outcome trials revealed no heightened infection risk in patients undergoing DPP-4 inhibitor therapy compared to control cohorts.展开更多
目的:基于生物信息学探讨与女性骨峰值(peak bone mass,PBM)及骨质疏松症(osteoporosis,OP)相关的基因并进行验证。方法:通过基因表达数据库(gene expression omnibus database,GEO),利用DNA微阵列技术对高PBM和低PBM成年女性的单核细...目的:基于生物信息学探讨与女性骨峰值(peak bone mass,PBM)及骨质疏松症(osteoporosis,OP)相关的基因并进行验证。方法:通过基因表达数据库(gene expression omnibus database,GEO),利用DNA微阵列技术对高PBM和低PBM成年女性的单核细胞进行全基因组范围内的基因差异表达研究,通过聚类分析、GO富集和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)分析差异基因,并进一步分析差异表达基因间的相互作用网络。建立OP大鼠模型,进行股骨颈组织染色,进一步验证差异基因的表达。结果:差异基因筛选共得到283个基因,与高PBM样本相比,低PBM样本中有135个基因表达上调,148个基因表达下调,总共有7个通路与12个差异基因被富集,涉及矿物质吸收与转运、细胞免疫等方面的多个基因表达存在差异。其中,CACNA1D基因编码的L型钙离子通道蛋白1.3(voltage-gated Ca^(2+)channel 1.3,CaV1.3)在OP大鼠模型股骨颈组织中表达显著增强。结论:以上结果提示CaV1.3基因表达水平的差异可能导致低PBM女性发生OP,提供了OP防治的潜在靶点。展开更多
文摘一般的量子图像加密算法虽然能达到加密效果,但需要的量子比特数较多,计算复杂度较高,为优化这一问题,提出了一种位平面分解的量子彩色图像加密方案。首先,采用一种位平面序信息单独编码的彩色数字图像量子表示模型(quantum representation model of color digital image,QRCI)来表示图像,利用量子交换门设计一种量子位交换操作,并作用于彩色图像中,对图像像素进行置乱,同时再对图像进行颜色通道交换操作。其次,对位平面序列进行反序操作,进一步加强置乱效果。接着,利用安全散列算法(secure hash algorithm 256,SHA-256)产生的哈希值来确定混沌系统的初始值。最后,利用混沌系统产生的序列对图像进行扩散,完成加密过程,形成加密图像。数值分析表明,相较于以往的加密方案,此方案大大降低了彩色图像存储时所需的量子比特位数,同时其密钥空间大,灵敏度高。仿真结果表明,该方案加密效果好,能抵御大部分常见的攻击。
基金Supported by National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-015CAMS Innovation Fund for Medical Sciences,No.2021-1-12M-002+1 种基金CAMS Innovation Fund for Medical Sciences,No.2023-I2M-C&T-B-043Beijing Municipal Natural Science Foundation,No.M22014.
文摘BACKGROUND The measurement of triceps skinfold(TSF)thickness serves as a noninvasive metric for evaluating subcutaneous fat distribution.Despite its clinical utility,the TSF thickness trajectories and their correlation with overall mortality have not been thoroughly investigated.AIM To explore TSF thickness trajectories of Chinese adults and to examine their associations with all-cause mortality.METHODS This study encompassed a cohort of 14747 adults sourced from the China Health and Nutrition Survey.Latent class trajectory modeling was employed to identify distinct trajectories of TSF thickness.Subjects were classified into subgroups reflective of their respective TSF thickness trajectory.We utilized multivariate Cox regression analyses and mediation examinations to explore the link between TSF thickness trajectory and overall mortality,including contributory factors.RESULTS Upon adjustment for multiple confounding factors,we discerned that males in the‘Class 2:Thin-stable’and‘Class 3:Thin-moderate’TSF thickness trajectories exhibited a markedly reduced risk of mortality from all causes in comparison to the‘Class 1:Extremely thin’subgroup.In the mediation analyses,the Geriatric Nutritional Risk Index was found to be a partial intermediary in the relationship between TSF thickness trajectories and mortality.For females,a lower TSF thickness pattern was significantly predictive of elevated all-cause mortality risk exclusively within the non-elderly cohort.CONCLUSION In males and non-elderly females,lower TSF thickness trajectories are significantly predictive of heightened mortality risk,independent of single-point TSF thickness,body mass index,and waist circumference.
基金Supported by CAMS Innovation Fund for Medical Sciences,No.2023-I2M-C&T-B-043 and No.2021-I2M-1-002National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-015+1 种基金Beijing Municipal Natural Science Foundation,No.M22014National Natural Science Foundation of China,No.91846106.
文摘BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)therapy.AIM To evaluate the risk of infection in patients with T2DM treated with dipeptidyl-peptidase 4(DPP-4)inhibitors.METHODS Electronic databases were searched.The selection criteria included randomized controlled trials focused on cardiovascular outcomes.In these studies,the effects of DPP-4 inhibitors were directly compared to those of either other active anti-diabetic treatments or placebo.Six trials involving 53616 patients were deemed eligible.We calculated aggregate relative risks employing both random-effects and fixed-effects approaches,contingent upon the context.RESULTS The application of DPP-4 inhibitors showed no significant link to the overall infection risk[0.98(0.95,1.02)]or the risk of serious infections[0.96(0.85,1.08)],additionally,no significant associations were found with opportunistic infections[0.69(0.46,1.04)],site-specific infections[respiratory infection 0.99(0.96,1.03),urinary tract infections 1.02(0.95,1.10),abdominal and gastrointestinal infections 1.02(0.83,1.25),skin structure and soft tissue infections 0.81(0.60,1.09),bone infections 0.96(0.68,1.36),and bloodstream infections 0.97(0.80,1.18)].CONCLUSION This meta-analysis of data from cardiovascular outcome trials revealed no heightened infection risk in patients undergoing DPP-4 inhibitor therapy compared to control cohorts.
文摘目的:基于生物信息学探讨与女性骨峰值(peak bone mass,PBM)及骨质疏松症(osteoporosis,OP)相关的基因并进行验证。方法:通过基因表达数据库(gene expression omnibus database,GEO),利用DNA微阵列技术对高PBM和低PBM成年女性的单核细胞进行全基因组范围内的基因差异表达研究,通过聚类分析、GO富集和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)分析差异基因,并进一步分析差异表达基因间的相互作用网络。建立OP大鼠模型,进行股骨颈组织染色,进一步验证差异基因的表达。结果:差异基因筛选共得到283个基因,与高PBM样本相比,低PBM样本中有135个基因表达上调,148个基因表达下调,总共有7个通路与12个差异基因被富集,涉及矿物质吸收与转运、细胞免疫等方面的多个基因表达存在差异。其中,CACNA1D基因编码的L型钙离子通道蛋白1.3(voltage-gated Ca^(2+)channel 1.3,CaV1.3)在OP大鼠模型股骨颈组织中表达显著增强。结论:以上结果提示CaV1.3基因表达水平的差异可能导致低PBM女性发生OP,提供了OP防治的潜在靶点。
