Background Kawasaki disease(KD)is the systemic vasculitis with unknown cause.The S100 protein outside cells have an important effect on congenital and adaptive immunity,chemotaxis,white blood cell(WBC)and tumor cell i...Background Kawasaki disease(KD)is the systemic vasculitis with unknown cause.The S100 protein outside cells have an important effect on congenital and adaptive immunity,chemotaxis,white blood cell(WBC)and tumor cell invasion,tissue growth and repair.Recently,multiple works have investigated the value of S100 proteins as the predictive biomarker of KD.The most serious complication of KD is coronary artery aneurysm(CAA).KD is the most common cause of acquired heart disease among children within developed countries and a risk factor for myocardial infarction in early adulthood.Early treatment with intravenous immunoglobulin(IVIG)has been shown to reduce the risk of CAA in KD from 15%-25%to about 4%.S100 family proteins are calcium-binding proteins,some of which have been shown to have intracellular and extracellular functions associated with inflammation.Persistent elevation of S100 protein level(S100A8/A9 and S100A12)after IVIG therapy was reported in patients suffering CAA.In this paper,the role and mechanism of S100 protein family in CAA development in patients with KD were briefly reviewed.展开更多
基金supported by Hubei Pediatric Alliance Medical Research Project(No.HPAMRP202117)。
文摘Background Kawasaki disease(KD)is the systemic vasculitis with unknown cause.The S100 protein outside cells have an important effect on congenital and adaptive immunity,chemotaxis,white blood cell(WBC)and tumor cell invasion,tissue growth and repair.Recently,multiple works have investigated the value of S100 proteins as the predictive biomarker of KD.The most serious complication of KD is coronary artery aneurysm(CAA).KD is the most common cause of acquired heart disease among children within developed countries and a risk factor for myocardial infarction in early adulthood.Early treatment with intravenous immunoglobulin(IVIG)has been shown to reduce the risk of CAA in KD from 15%-25%to about 4%.S100 family proteins are calcium-binding proteins,some of which have been shown to have intracellular and extracellular functions associated with inflammation.Persistent elevation of S100 protein level(S100A8/A9 and S100A12)after IVIG therapy was reported in patients suffering CAA.In this paper,the role and mechanism of S100 protein family in CAA development in patients with KD were briefly reviewed.
