Depression is a mental disorder with high morbidity,disability and relapse rates.Ginkgo biloba extract(GBE),a traditional Chinese medicine,has a long history of clinical application in the treatment of cerebral and me...Depression is a mental disorder with high morbidity,disability and relapse rates.Ginkgo biloba extract(GBE),a traditional Chinese medicine,has a long history of clinical application in the treatment of cerebral and mental disorders,but the key mechanism remains incompletely understood.Here we showed that GEB exerted anti-depressant effect in mice through regulating gut microbial metabolism.GBE protected against unpredictable mild stress(UMS)-induced despair,anxiety-like and social avoidance behavior in mice without sufficient brain distribution.Fecal microbiome transplantation transmitted,while antibiotic cocktail abrogated the protective effect of GBE.Spatiotemporal bacterial profiling and metabolomics assay revealed a potential involvement of Parasutterella excrementihominis and the bile acid metabolite ursodeoxycholic acid(UDCA)in the effect of GBE.UDCA administration induced depression-like behavior in mice.Together,these findings suggest that GBE acts on gut microbiome-modulated bile acid metabolism to alleviate stress-induced depression.展开更多
基金supported by the National Natural Science Foundation of China(Nos.81930109,82274009,and 81973556)the National Key Research and Development Programme of China(No.2021YFA1301300)+1 种基金the“Double-First"Discipline Funding of China Pharmaceutical University(No.CPUQNJC22_09)CAMS Innovation Fund for Medical Sciences(No.2021-12M-5-011)。
文摘Depression is a mental disorder with high morbidity,disability and relapse rates.Ginkgo biloba extract(GBE),a traditional Chinese medicine,has a long history of clinical application in the treatment of cerebral and mental disorders,but the key mechanism remains incompletely understood.Here we showed that GEB exerted anti-depressant effect in mice through regulating gut microbial metabolism.GBE protected against unpredictable mild stress(UMS)-induced despair,anxiety-like and social avoidance behavior in mice without sufficient brain distribution.Fecal microbiome transplantation transmitted,while antibiotic cocktail abrogated the protective effect of GBE.Spatiotemporal bacterial profiling and metabolomics assay revealed a potential involvement of Parasutterella excrementihominis and the bile acid metabolite ursodeoxycholic acid(UDCA)in the effect of GBE.UDCA administration induced depression-like behavior in mice.Together,these findings suggest that GBE acts on gut microbiome-modulated bile acid metabolism to alleviate stress-induced depression.
