In order to develop novel spirocyclic tetronic acid lead compounds,a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed.The stmctures of 16 target compound...In order to develop novel spirocyclic tetronic acid lead compounds,a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed.The stmctures of 16 target compounds were characterized by lH NMR spectra,13C NMR spectra and high-resolution mass spectrometer(HRMS).Preliminary bioassays indicated that most of the title compounds displayed excellent insecticidal activity against Aphis fabae and Nilapmyata lugens at 100 mg/L.In particular,compound 6k showed the similar activity(LC50=6.87 mg/L)against A.fabae as the spirotetramat(LC50=4.56 mg/L)and had better efIects(LC50=l.64 mg/L)against N.lugens in comparison with spirotetramat(LC5o=7.90 mg/L).The study showed that compound 6k exhibited more promising and broad-spectrum insecticide activity and may serve as a new insecticidal agent for sucking pests.展开更多
文摘目的探讨经膀胱穿刺三点针刺阻滞麻醉法在膀胱肿瘤电切术中预防闭孔神经反射的疗效。方法 2011年2月至2019年3月共收治膀胱侧壁肿瘤患者115例,采用腰硬联合麻醉,均行经尿道膀胱肿瘤电切术,采用点切法,发生闭孔神经反射84例(73.0%),将其随机分成A、B两组。A组(42例)在肿瘤外上方一针法行闭孔神经阻滞,B组(42例)在肿瘤外上方三针法行闭孔神经阻滞。结果 A组有15例发生闭孔神经反射,占35.7%;B组有4例发生闭孔神经反射,占9.5%,差异有统计学意义( P <0.05)。两组均无膀胱穿孔及大出血。结论电切位于膀胱侧壁的肿瘤时易发生闭孔神经反射,点切法能有效防止膀胱穿孔,三针法经膀胱闭孔神经阻滞明显优于单针法。
基金Supported by the National Key Research&Development Program of China(No.2017YFDO2OO5O5)the Natural Science Foundation of Zhejiang Province,China(No.LY 19C140006).
文摘In order to develop novel spirocyclic tetronic acid lead compounds,a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed.The stmctures of 16 target compounds were characterized by lH NMR spectra,13C NMR spectra and high-resolution mass spectrometer(HRMS).Preliminary bioassays indicated that most of the title compounds displayed excellent insecticidal activity against Aphis fabae and Nilapmyata lugens at 100 mg/L.In particular,compound 6k showed the similar activity(LC50=6.87 mg/L)against A.fabae as the spirotetramat(LC50=4.56 mg/L)and had better efIects(LC50=l.64 mg/L)against N.lugens in comparison with spirotetramat(LC5o=7.90 mg/L).The study showed that compound 6k exhibited more promising and broad-spectrum insecticide activity and may serve as a new insecticidal agent for sucking pests.
