为降低基于接收信号强度指示(received signal strength indication,RSSI)测距误差,提出基于RSSI测距修正和集员法的节点定位算法(improved RSSI ranging and set membership based localization,I-RSSI-SM-L),通过修正RSSI测距,利用集...为降低基于接收信号强度指示(received signal strength indication,RSSI)测距误差,提出基于RSSI测距修正和集员法的节点定位算法(improved RSSI ranging and set membership based localization,I-RSSI-SM-L),通过修正RSSI测距,利用集员法估计节点位置,提高定位精度。在测距阶段,估算模型参数,通过测距误差校正测距值,建立置信区间;在定位阶段,通过集员法获取未知节点的位置的粗略范围,通过网格扫描法收缩范围,直至一点,此点位置就是未知节点的位置。实验结果表明,I-RSSI-SM-L算法降低了测距误差,抑制了定位的均方定位误差。展开更多
The present study was designed to investigate the antimalarial activity of synthetic hepcidin and its effect on cytokine secretion in mice infected with Plasmodium berghei.The mice were infected with P.berghei intrave...The present study was designed to investigate the antimalarial activity of synthetic hepcidin and its effect on cytokine secretion in mice infected with Plasmodium berghei.The mice were infected with P.berghei intravenously and treated with hepcidin according to 4-day suppression test and Rane's test.The serum levels of interleukins(IL-1β,IL-2,IL-6,IL-10,IL-12p70,and IL-17A),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ) in the experimental mice were determined using a cytometric bead array(CBA)kit.The survival rate of the infected mice was also registered.Additionally,the serum iron,alanine transaminase(ALT),aspartate transaminase(AST),and total bilirubin(BIL) were detected to evaluate liver functions.Hepcidin exerted direct anti-malarial function in vivo and increased survival rate in a dose-dependent manner.In addition,the secretion of T helper cell type 1(Th1),Th2,and Th17 cytokines,TNF-α,and IFN-γ were inhibited by hepcidin.In conclusion,our results demonstrated that synthetic hepcidin exerts in vivo antimalarial activity and possesses anti-inflammatory function,which provides a basis for future design of new derivatives with ideal anti-malarial activity.展开更多
文摘为降低基于接收信号强度指示(received signal strength indication,RSSI)测距误差,提出基于RSSI测距修正和集员法的节点定位算法(improved RSSI ranging and set membership based localization,I-RSSI-SM-L),通过修正RSSI测距,利用集员法估计节点位置,提高定位精度。在测距阶段,估算模型参数,通过测距误差校正测距值,建立置信区间;在定位阶段,通过集员法获取未知节点的位置的粗略范围,通过网格扫描法收缩范围,直至一点,此点位置就是未知节点的位置。实验结果表明,I-RSSI-SM-L算法降低了测距误差,抑制了定位的均方定位误差。
基金supported by the grants from China National Natural Science Foundation of Young Scientists(No.31201717)Special Foundation for Young Scientists of Jiangsu Province(No.BK2012365)Jiangsu Province Science and Technology Support Project(No.BE2012748)
文摘The present study was designed to investigate the antimalarial activity of synthetic hepcidin and its effect on cytokine secretion in mice infected with Plasmodium berghei.The mice were infected with P.berghei intravenously and treated with hepcidin according to 4-day suppression test and Rane's test.The serum levels of interleukins(IL-1β,IL-2,IL-6,IL-10,IL-12p70,and IL-17A),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ) in the experimental mice were determined using a cytometric bead array(CBA)kit.The survival rate of the infected mice was also registered.Additionally,the serum iron,alanine transaminase(ALT),aspartate transaminase(AST),and total bilirubin(BIL) were detected to evaluate liver functions.Hepcidin exerted direct anti-malarial function in vivo and increased survival rate in a dose-dependent manner.In addition,the secretion of T helper cell type 1(Th1),Th2,and Th17 cytokines,TNF-α,and IFN-γ were inhibited by hepcidin.In conclusion,our results demonstrated that synthetic hepcidin exerts in vivo antimalarial activity and possesses anti-inflammatory function,which provides a basis for future design of new derivatives with ideal anti-malarial activity.
