Pentraxin-3(PTX3),the prototype of long pentraxins,seems to influence complement system(CS)modulation.PTX3 and CS sustain carcinogenesis,enriching tumor microenvironment(TME)with pro-inflammatory molecules promoting a...Pentraxin-3(PTX3),the prototype of long pentraxins,seems to influence complement system(CS)modulation.PTX3 and CS sustain carcinogenesis,enriching tumor microenvironment(TME)with pro-inflammatory molecules promoting angiogenesis in prostate cancer(PC)and renal cell carcinoma(RCC).Furthermore,cancer cells overexpress complement regulatory proteins,such as CD46,CD55 and CD59,which negatively affect complement pathways for support cancer cells survival.This viewpoint aims to elucidate the ambivalent role of PTX3 and the CS in the context of tumor microenvironment(TME).展开更多
基金This work was supported by grant funding from University of Foggia(University Research Projects 2019“PRA 2019”granted to G.S.N.,2019).The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.The contents are solely the responsibility of the author and do not necessarily represent the official views of the University of Foggia.
文摘Pentraxin-3(PTX3),the prototype of long pentraxins,seems to influence complement system(CS)modulation.PTX3 and CS sustain carcinogenesis,enriching tumor microenvironment(TME)with pro-inflammatory molecules promoting angiogenesis in prostate cancer(PC)and renal cell carcinoma(RCC).Furthermore,cancer cells overexpress complement regulatory proteins,such as CD46,CD55 and CD59,which negatively affect complement pathways for support cancer cells survival.This viewpoint aims to elucidate the ambivalent role of PTX3 and the CS in the context of tumor microenvironment(TME).
