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利伐沙班对腹腔镜疝修补术后出血和血栓形成的影响
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作者 费晓舟 金淦 马玉亮 《中国药物应用与监测》 CAS 2024年第4期438-441,共4页
目的 探讨利伐沙班对腹腔镜疝修补手术患者术后出血、深静脉血栓形成(DVT)的影响。方法 选取2021年3月至2023年9月于绍兴市人民医院接受腹腔镜疝修补术治疗的患者122例,采用随机数字表法分为观察组与对照组,各61例,对照组给予低分子肝... 目的 探讨利伐沙班对腹腔镜疝修补手术患者术后出血、深静脉血栓形成(DVT)的影响。方法 选取2021年3月至2023年9月于绍兴市人民医院接受腹腔镜疝修补术治疗的患者122例,采用随机数字表法分为观察组与对照组,各61例,对照组给予低分子肝素治疗,观察组给予利伐沙班治疗。对比两组治疗前后凝血指标、纤溶指标、术后出血事件及DVT发生情况。结果 治疗后,两组纤维蛋白原(FIB)、凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)均较治疗前下降(均P<0.05),且观察组FIB、PT、APTT[分别为(3.08±0.51) g·L^(-1)、(12.02±1.19) s、(31.68±3.42) s]高于对照组[分别为(1.92±0.46) g·L^(-1)、(10.05±1.27) s、(25.82±3.36) s](t=13.191,8.841,9.546,均P<0.05)。治疗后,两组D-二聚体(D-D)、组织纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物-1(PAI-1)水平均较治疗前上升(均P<0.05),且观察组D-D、PAI-1[分别为(7.98±1.47) mg·L^(-1)、(33.92±6.19) ng·L^(-1)]低于对照组[分别为(11.75±1.68) mg·L^(-1)、(39.72±6.73) ng·L^(-1)](t=13.190,4.954,均P<0.05),观察组t-PA水平高于对照组[(13.02±1.83) ng·L^(-1) vs (11.59±1.79) ng·L^(-1),t=4.363,P<0.05]。两组出血事件及DVT发生率比较均差异无统计学意义(8.20%vs 4.91%、0%vs 4.91%,χ^(2)=0.480,1.367,均P<0.05)。结论 利伐沙班能有效改善腹腔镜疝修补术患者的凝血功能,减少DVT的发生,安全性高。 展开更多
关键词 腹股沟疝 腹腔镜疝修补术 利伐沙班 低分子肝素 血栓 凝血功能
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Role of dissection of secondary branches of splenic pedicle in portal hypertension cases undergoing splenectomy 被引量:4
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作者 LIU Ying-bin KONG Ying +14 位作者 WANG Xu-an WANG Jian-wei LI Jiang-tao WANG Yong CHEN Yan CHEN De-qing WENG Wei-hong ZHANG Zhi-ping WU Xiang-song fei xiao-zhou QUAN Zhi-wei Li Song-gang LI Ji-yu CAO Li-ping PENG Shu-you 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第22期2250-2253,共4页
Background It is well known that conventional splenectomy, which requires careful handling and ligation of tissue of the splenic hilum, can easily cause complications such as splenic fever and pancreatic fistula. Here... Background It is well known that conventional splenectomy, which requires careful handling and ligation of tissue of the splenic hilum, can easily cause complications such as splenic fever and pancreatic fistula. Here, we use the technique of dissection of the secondary branches of the splenic pedicle to handle the hilum in the portal hypertension patients who are subjected to splenectomy. Methods We retrospectively compared and analyzed the complications, postoperative hospital stay, operative time, and occurrence of hemorrhage in 121 patients with portal hypertension undergoing splenectomy and devascularization of the gastric cardia from January 1999 to December 2007. The selected cases consisted of 51 patients undergoing conventional splenectomy and 70 patients undergoing dissection of secondary branches of the splenic pedicle. In addition, we analyzed the relationship between size of the spleen and occurrence of complications. Results The incidence of pancreatic fistula and splenic fever (0/70 and 9/70) was lower in patients undergoing dissection of secondary branches of the splenic pedicle as compared with that of the conventional group (5/51 and 18/51 respectively). In addition, there was no significant difference in operative time and volume of blood loss between two groups. The spleen thickness of those patients who had pancreatic fistula and splenic fever was significantly greater than those without complications. Conclusions These results indicate that dissection of secondary branches of the splenic pedicle in portal hypertension patients undergoing splenectomy can decrease the incidence of splenic fever and pancreatic fistula, and shorten the postoperative hospital stay, especially in the patients with a large spleen. So dissection of secondary branches of the splenic pedicle is a valuable technique for splenectomy. 展开更多
关键词 SPLENECTOMY portal hypertension
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