Objective To observe the value of isotropic volumetric MRI for displaying perineural spread(PNS)of cranial nerve(CN)in nasopharyngeal carcinoma.Methods Eighty-seven patients with pathologically proven nasopharyngeal c...Objective To observe the value of isotropic volumetric MRI for displaying perineural spread(PNS)of cranial nerve(CN)in nasopharyngeal carcinoma.Methods Eighty-seven patients with pathologically proven nasopharyngeal carcinoma were prospectively enrolled.MR scanning,including three-dimensional liver acquisition with volume acceleration-flexible(3D LAVA_Flex)image,T2WI with fat suppression(T2WI-FS),T1WI,contrast enhancement(CE)T1WI-FS of nasopharynx and neck region were performed.The displaying rates of CN PNS were evaluated and compared between 3D LAVA_Flex and T2WI-FS,T1WI,CE-T1WI-FS at patient level,CN group level and neural level,respectively.Results The displaying rate of CN PNS in all 87 nasopharyngeal carcinoma patients by 3D LAVA_Flex sequence was 49.43%(43/87),higher than that of conventional MRI(30/87,34.48%,P=0.001).Among 59 patients with advanced nasopharyngeal carcinoma diagnosed with conventional sequences,the displaying rate of CN PNS was 71.19%(42/59)by 3D LAVA-Flex sequence,higher than that of conventional MRI(30/59,50.85%,P=0.001).At both patient level and posterior CN level,significant differences of the displaying rate of CN PNS were found between 3D LAVA-Flex sequence and T2WI-FS,T1WI,CE-T1WI-FS,while at CN level,the displaying rates of mandibular nerve PNS,CNⅨ—ⅪPNS in jugular foramen(P<0.05)and CNⅨ—ⅫPNS in carotid space of 3D LAVA_Flex sequence were all significantly higher than that of T2WI-FS,T1WI and CE-T1WI-FS(all P<0.05),of PNS of CNⅢ—Ⅴin cavernous sinus were higher than that of T2WI-FS(P<0.05),while of PNS of hypoglossal nerve were significantly higher than that of T2WI-FS and T1WI(both P<0.05).Conclusion 3D LAVA_Flex sequence could be used to effectively display CN PNS of nasopharyngeal carcinoma.展开更多
"Riding mining" is a form of mining where the working face is located above the roadway and advances parallel to it.Riding mining in deep soft rock creates a particular set of problems in the roadway that in..."Riding mining" is a form of mining where the working face is located above the roadway and advances parallel to it.Riding mining in deep soft rock creates a particular set of problems in the roadway that include high stresses,large deformations,and support difficulties.Herein we describe a study of the rock deformation mechanism of a roadway as observed during riding mining in deep soft rock.Theoretical analysis,numerical simulations,and on site monitoring were used to examine this problem.The stress in the rock and the visco-elastic behavior of the rock are considered.Real time data,recorded over a period of 240 days,were taken from a 750 transportation roadway.Stress distributions in the rock surrounding the roadway were studied by comparing simulations to observations from the mine.The rock stress shows dynamic behavior as the working face advances.The pressure increases and then drops after peaking as the face advances.Both elastic and plastic deformation of the surrounding rock occurs.Plastic deformation provides a mechanism by which stress in the rock relaxes due to material flow.A way to rehabilitate the roadway is suggested that will help ensure mine safety.展开更多
文摘Objective To observe the value of isotropic volumetric MRI for displaying perineural spread(PNS)of cranial nerve(CN)in nasopharyngeal carcinoma.Methods Eighty-seven patients with pathologically proven nasopharyngeal carcinoma were prospectively enrolled.MR scanning,including three-dimensional liver acquisition with volume acceleration-flexible(3D LAVA_Flex)image,T2WI with fat suppression(T2WI-FS),T1WI,contrast enhancement(CE)T1WI-FS of nasopharynx and neck region were performed.The displaying rates of CN PNS were evaluated and compared between 3D LAVA_Flex and T2WI-FS,T1WI,CE-T1WI-FS at patient level,CN group level and neural level,respectively.Results The displaying rate of CN PNS in all 87 nasopharyngeal carcinoma patients by 3D LAVA_Flex sequence was 49.43%(43/87),higher than that of conventional MRI(30/87,34.48%,P=0.001).Among 59 patients with advanced nasopharyngeal carcinoma diagnosed with conventional sequences,the displaying rate of CN PNS was 71.19%(42/59)by 3D LAVA-Flex sequence,higher than that of conventional MRI(30/59,50.85%,P=0.001).At both patient level and posterior CN level,significant differences of the displaying rate of CN PNS were found between 3D LAVA-Flex sequence and T2WI-FS,T1WI,CE-T1WI-FS,while at CN level,the displaying rates of mandibular nerve PNS,CNⅨ—ⅪPNS in jugular foramen(P<0.05)and CNⅨ—ⅫPNS in carotid space of 3D LAVA_Flex sequence were all significantly higher than that of T2WI-FS,T1WI and CE-T1WI-FS(all P<0.05),of PNS of CNⅢ—Ⅴin cavernous sinus were higher than that of T2WI-FS(P<0.05),while of PNS of hypoglossal nerve were significantly higher than that of T2WI-FS and T1WI(both P<0.05).Conclusion 3D LAVA_Flex sequence could be used to effectively display CN PNS of nasopharyngeal carcinoma.
基金Supported by the National Natural Science Foundation of China (Nos. 50834005 and 51074163)the Ministry of Education Support Program for New Century Excellent of China(No. NCET-08-0837)+1 种基金the Fundamental Research Funds for the Central Universities of ChinaYouth Science and Technology Foundation of China University of Mining and Technology(No. 2010QNB25)
文摘"Riding mining" is a form of mining where the working face is located above the roadway and advances parallel to it.Riding mining in deep soft rock creates a particular set of problems in the roadway that include high stresses,large deformations,and support difficulties.Herein we describe a study of the rock deformation mechanism of a roadway as observed during riding mining in deep soft rock.Theoretical analysis,numerical simulations,and on site monitoring were used to examine this problem.The stress in the rock and the visco-elastic behavior of the rock are considered.Real time data,recorded over a period of 240 days,were taken from a 750 transportation roadway.Stress distributions in the rock surrounding the roadway were studied by comparing simulations to observations from the mine.The rock stress shows dynamic behavior as the working face advances.The pressure increases and then drops after peaking as the face advances.Both elastic and plastic deformation of the surrounding rock occurs.Plastic deformation provides a mechanism by which stress in the rock relaxes due to material flow.A way to rehabilitate the roadway is suggested that will help ensure mine safety.
