Cell division must be tightly coupled to cell growth in order to maintain cell size,whereas the mechanisms of how initialization of mitosis is regulated by cell size remain to be elucidated.We develop a mathematical m...Cell division must be tightly coupled to cell growth in order to maintain cell size,whereas the mechanisms of how initialization of mitosis is regulated by cell size remain to be elucidated.We develop a mathematical model of the cell cycle,which incorporates cell growth to investigate the dynamical properties of the size checkpoint in embryos of Xenopus laevis.We show that the size checkpoint is naturally raised from a saddle-node bifurcation,and in a mutant case,the cell loses its size control ability due to the loss of this saddle-node point.展开更多
基金Supported by the National Natural Science Foundation of China under Grant No 10971152.
文摘Cell division must be tightly coupled to cell growth in order to maintain cell size,whereas the mechanisms of how initialization of mitosis is regulated by cell size remain to be elucidated.We develop a mathematical model of the cell cycle,which incorporates cell growth to investigate the dynamical properties of the size checkpoint in embryos of Xenopus laevis.We show that the size checkpoint is naturally raised from a saddle-node bifurcation,and in a mutant case,the cell loses its size control ability due to the loss of this saddle-node point.
