通过对中江气田沙溪庙组储层的岩石学、物性、储集空间类型、成岩作用等基本特征的研究,明确了本区储层形成的主控因素,建立了优质储层的地质模型,并据此预测出本区优质储层的分布。中江气田沙溪庙组岩石类型以岩屑长石砂岩和长石岩屑...通过对中江气田沙溪庙组储层的岩石学、物性、储集空间类型、成岩作用等基本特征的研究,明确了本区储层形成的主控因素,建立了优质储层的地质模型,并据此预测出本区优质储层的分布。中江气田沙溪庙组岩石类型以岩屑长石砂岩和长石岩屑砂岩为主,具有富长石的特征。储层平均孔隙度为9.0%,平均渗透率为0.096 m D,属于低孔低渗致密砂岩储层。孔隙类型主要为剩余粒间孔和粒间溶孔,其次为粒内溶孔。储层总体表现出沉积-成岩控储的特征,有利储层的地质模型是:较粗粒度,高长石、低岩屑,低碳酸盐胶结物,不同地区不同层段优质储层的分布均有不同。展开更多
Two enantiomeric 2-trifluoromethyl-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d] pyrimidin-4-amine derivatives were synthesized by nucleophilic substitution of two chiral amines with 4-chloro-2-trifiuoromethyl-6,7-dihyd...Two enantiomeric 2-trifluoromethyl-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d] pyrimidin-4-amine derivatives were synthesized by nucleophilic substitution of two chiral amines with 4-chloro-2-trifiuoromethyl-6,7-dihydro-5H-cyclopenta[4~5]thieno[2-3-d]pyrimidine, which started from 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile, trifluoroacetic acid （TFA） and phosphoryl trichloride via one-pot procedure. Their structures were determined by single-crystal X-ray diffraction. Enantiomer （R）-3,（R）-N-（1-phenylethyl）-2-trifluoromethyl-6,7- dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine crystallizes in the tetragonal system, space group P43 with a = 8.6847（6）, b = 8.6847（6）, c = 22.419（2） A, V= 1690.9（3） A3, Z = 4, Dc = 1.428 g/cm^3, p = 0.228 mm-1, F（000） = 752, the final R = 0.0463 and wR = 0.1257 for 3442 observed reflections with 1〉 20（/）. Enantiomer （S）-3,（S）-N-（1-phenylethyl）-2-trifluoromethyl-6,7-dihydro- 5H-cycloperita[4,5]thieno[2,3-d]pyrimidin-4-amine crystallizes in the tetragonal system, space group P41 with a = 8.688, b = 8.688, c = 22.421 A, V = 1692.4 A3, Z = 4, Dc = 1.426 g/cm^3, μ= 0.227 mm^-1, F（000） = 752, the final R = 0.0682 and wR = 0.1806 for 3182 observed reflections with ≥20（I）. The preliminary bioassay indicated that the R-enantiomer exhibits higher antitumor activity against MCF-7 than gefitinib.展开更多
文摘通过对中江气田沙溪庙组储层的岩石学、物性、储集空间类型、成岩作用等基本特征的研究,明确了本区储层形成的主控因素,建立了优质储层的地质模型,并据此预测出本区优质储层的分布。中江气田沙溪庙组岩石类型以岩屑长石砂岩和长石岩屑砂岩为主,具有富长石的特征。储层平均孔隙度为9.0%,平均渗透率为0.096 m D,属于低孔低渗致密砂岩储层。孔隙类型主要为剩余粒间孔和粒间溶孔,其次为粒内溶孔。储层总体表现出沉积-成岩控储的特征,有利储层的地质模型是:较粗粒度,高长石、低岩屑,低碳酸盐胶结物,不同地区不同层段优质储层的分布均有不同。
基金Supported by the National Natural Science Foundation of China(No.21262012)the Natural Science Foundation of Hubei Province(No.2014CFB621)+3 种基金the Scientific and Technological Innovation Team Project of Hubei University for Nationalities(No.MY2014T004)the Project of New Strategic Industries for Fostering Talents in Applied Chemistry of Higher Education of Hubei Provincethe Open Fund of Key Laboratory of Biologic Resources Protection&Utilization of Hubei Province(No.PKLHB1506)the First-class Discipline of Forestry in Hubei University for Nationalities
文摘Two enantiomeric 2-trifluoromethyl-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d] pyrimidin-4-amine derivatives were synthesized by nucleophilic substitution of two chiral amines with 4-chloro-2-trifiuoromethyl-6,7-dihydro-5H-cyclopenta[4~5]thieno[2-3-d]pyrimidine, which started from 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile, trifluoroacetic acid （TFA） and phosphoryl trichloride via one-pot procedure. Their structures were determined by single-crystal X-ray diffraction. Enantiomer （R）-3,（R）-N-（1-phenylethyl）-2-trifluoromethyl-6,7- dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-amine crystallizes in the tetragonal system, space group P43 with a = 8.6847（6）, b = 8.6847（6）, c = 22.419（2） A, V= 1690.9（3） A3, Z = 4, Dc = 1.428 g/cm^3, p = 0.228 mm-1, F（000） = 752, the final R = 0.0463 and wR = 0.1257 for 3442 observed reflections with 1〉 20（/）. Enantiomer （S）-3,（S）-N-（1-phenylethyl）-2-trifluoromethyl-6,7-dihydro- 5H-cycloperita[4,5]thieno[2,3-d]pyrimidin-4-amine crystallizes in the tetragonal system, space group P41 with a = 8.688, b = 8.688, c = 22.421 A, V = 1692.4 A3, Z = 4, Dc = 1.426 g/cm^3, μ= 0.227 mm^-1, F（000） = 752, the final R = 0.0682 and wR = 0.1806 for 3182 observed reflections with ≥20（I）. The preliminary bioassay indicated that the R-enantiomer exhibits higher antitumor activity against MCF-7 than gefitinib.
