The practical deployment of metallic anodes in the energy-dense batteries is impeded by the thermodynamically unstable interphase in contact with the aprotic electrolyte,structural collapse of the substrates as well a...The practical deployment of metallic anodes in the energy-dense batteries is impeded by the thermodynamically unstable interphase in contact with the aprotic electrolyte,structural collapse of the substrates as well as their insufficient affinity toward the metallic deposits.Herein,the mechanical flexible,lightweight(1.2 mg cm^(−2))carbon nanofiber scaffold with the monodispersed,ultrafine Sn_(4)P_(3) nanoparticles encapsulation(Sn_(4)P_(3)NPs@CNF)is proposed as the deposition substrate toward the high-areal-capacity sodium loadings up to 4 mAh cm^(−2).First-principles calculations manifest that the alloy intermediates,namely the Na_(15)Sn_(4) and Na_(3)P matrix,exhibit the intimate Na affinity as the“sodiophilic”sites.Meanwhile,the porous CNF regulates the heterogeneous alloying process and confines the deposit propagation along the nanofiber orientation.With the precise control of pairing mode with the NaVPO4F cathode(8.7 mg cm^(−2)),the practical feasibility of the Sn_(4)P_(3) NPs@CNF anode(1^(*)Na excess)is demonstrated in 2 mAh single-layer pouch cell prototype,which achieves the 95.7%capacity retention for 150 cycles at various mechanical flexing states as well as balanced energy/power densities.展开更多
In view of the shortcomings of poor temperature resistance, poor pumpability and poor pressure-bearing capacity of commonly used gel plugging materials, polyacrylamide (HPAM) and N,N-methylene bisacrylamide (BIS) were...In view of the shortcomings of poor temperature resistance, poor pumpability and poor pressure-bearing capacity of commonly used gel plugging materials, polyacrylamide (HPAM) and N,N-methylene bisacrylamide (BIS) were selected for crosslinking and compounding to make a new type of gel plugging material with high temperature and pressure resistance. The compressive strength and yield stress were measured by inverted observation method to evaluate the gel strength. The anti-temperature, anti-pressure, anti-dilution and gel-breaking properties of the gel were evaluated. Finally, 71 type high temperature and high pressure water loss instrument and high temperature and high pressure filter with slit plate were used to evaluate the plugging capacity of gel plugging agent. The experimental results show that the new gel plugging system between 100°C - 120°C, gelation time can be controlled at about 5 h;it has strong temperature resistance, compression resistance, dilution resistance and gel breaking performance. In the face of permeability and fracture leakage simulation experiments, when the ambient temperature below 120°C, pressure within 5 MPa, the filter loss of gel plugging agent is far less than the market two conventional plugging agent, has excellent plugging performance.展开更多
In complex strata, oil-based drilling fluid is the preferred drilling fluid system, but its preparation cost is high, and there are hidden safety risks. Therefore, the new progress of high-performance anti-collapse wa...In complex strata, oil-based drilling fluid is the preferred drilling fluid system, but its preparation cost is high, and there are hidden safety risks. Therefore, the new progress of high-performance anti-collapse water-based drilling fluid at home and abroad is analyzed. It is difficult to prevent and control the well collapse. Once the well wall instability problem occurs, it will often bring huge economic losses to the enterprises, and the underground safety accidents will occur. In order to ensure the stability of the well wall and improve the downhole safety, the key treatment agent of water-based collapse drilling fluid is selected, the anti-collapse drilling fluid system is formulated, the evaluation method of drilling fluid prevention performance is established, and a set of water-based drilling fluid system suitable for easy to collapse strata in China is selected to ensure the downhole safety. The development trend of high performance anti-collapse water-based drilling fluid is expected to provide a reference for the research of high performance anti-collapse water-based drilling fluid system and key treatment agent.展开更多
This project is explaining a laboratory development of a solid free drilling fluid formula that could be potentially used in tight gas reservoirs. The configuration of the weak gel fluid WGL-1, which is resistant to h...This project is explaining a laboratory development of a solid free drilling fluid formula that could be potentially used in tight gas reservoirs. The configuration of the weak gel fluid WGL-1, which is resistant to high temperature and high salt, was tested, and concluded that its gelling properties, salt and temperature resistance, and environmental protection were all in line with industry requirements. The final drilling fluid formula was developed as: water + (0.3% ~ 0.5%) NaOH + 5% KCl + 2% WGL-1 + 5% NaCl + (1.0% ~ 2.0%) HBFR Anti-high temperature fluid loss agent + 2% Polyol + (1.5% ~ 2.0%) SDL-1 Lubricant + 0.4% A4O1. The performance of the liquid was tested for temperature resistance, inhibition, gas formation protection effect, plugging performance, and static settlement stability. It was concluded that the temperature resistance performance is satisfied at 150°C, and the cuttings recovery rate is as high as 96.78%. It has good performance in inhibiting water dispersion and swelling of cuttings. The permeability recovery value reaches 88.9%, which meets the requirements of gas formation protection. The SSSI value shows that its settlement stability is good;under high temperature and high pressure, its sealing performance is good. This drilling fluid system has achieved the expected results and laid a foundation for further promoting the development of solid-free drilling fluid systems. The future development direction of solid-free drilling fluids is pointed out, to the improvement of properties to be applied in high temperature environment and have high salt resistance capacity.展开更多
Myelin-associated glycoprotein(MAG) inhibits the growth of neurites from nerve cells. Extraction and purification of MAG require complex operations; therefore, we attempted to determine whether commercially availabl...Myelin-associated glycoprotein(MAG) inhibits the growth of neurites from nerve cells. Extraction and purification of MAG require complex operations; therefore, we attempted to determine whether commercially available MAG-Fc can replace endogenous MAG for research purposes. Immunofluorescence using specific antibodies against MAG, Nogo receptor(NgR) and paired immunoglobulin-like receptor B(PirB) was used to determine whether MAG-Fc can be endocytosed by neuro-2a cells. In addition, neurite outgrowth of neuro-2a cells treated with different doses of MAG-Fc was evaluated. Enzyme linked immunosorbent assays were used to measure RhoA activity. Western blot assays were conducted to assess Rho-associated protein kinase(ROCK) phosphorylation. Neuro-2a cells expressed NgR and PirB, and MAG-Fc could be endocytosed by binding to NgR and PirB. This activated intracellular signaling pathways to increase RhoA activity and ROCK phosphorylation, ultimately inhibiting neurite outgrowth. These findings not only verify that MAG-Fc can inhibit the growth of neural neurites by activating RhoA signaling pathways, similarly to endogenous MAG, but also clearly demonstrate that commercial MAG-Fc is suitable for experimental studies of neurite outgrowth.展开更多
Precluding the excessive lipoproteins from plasma rapidly and effectively is highly needed for biomedical detection and reducing plasma product scrap in blood donation stations.The current centrifugation procedure is ...Precluding the excessive lipoproteins from plasma rapidly and effectively is highly needed for biomedical detection and reducing plasma product scrap in blood donation stations.The current centrifugation procedure is high-cost and time-consuming.Herein,we fabricated an anionic microfiltration polyethersulfone(PES)membrane modified by interface swelling and implanting of acrylic acid(AA)for screening out large particle lipoprotein chylomicron(CM)and adsorbing cationic very low-density lipoproteins(VLDL).To improve the separation efficiency,a two-stage filtration through carboxylated polyethersulfone microfiltration membranes with the mean pore size of 0.45 and 0.22μm respectively were conducted.Attenuated total reflection Fourier transform infrared technique(ATR-FTIR),water contact angle(WCA),Zeta potential and scanning electron microscope(SEM)were employed to characterize the modified membrane.To test the effectiveness of this membrane,plasma flux and concentration variation of plasma components were examined to study the purification effectiveness.Furthermore,the hemocompatibility of modified membranes was tested to confirm its practicability on bloodcontacting materials.The carboxylated polyethersulfone microfiltration membrane shows its promising potential application to purify chylous plasma.展开更多
A novel yield criterion based on CPB06 considering anisotropic and tension-compression asymmetric behaviors of magnesium alloys was derived and proposed(called M_CPB06).This yield criterion can simultaneously predict ...A novel yield criterion based on CPB06 considering anisotropic and tension-compression asymmetric behaviors of magnesium alloys was derived and proposed(called M_CPB06).This yield criterion can simultaneously predict the yield stresses and the Lankford ratios at different angles(if any)under uniaxial tension,compression,equal-biaxial and equal-compression conditions.Then,in order to further describe the anisotropic strain-hardening characteristics of magnesium alloy,the proposed M_CPB06 criterion was further evolved to the M_CPB06ev model by expressing the parameters of the M_CPB06 model as functions of the plastic strain.As the model was developed,the stresses and Lankford ratios of AZ31B and ZK61M magnesium alloys at different angles under tensile,compressive and through-thickness compressive conditions were used to calibrate the M_CPB06/M_CPB06ev and the existing CPB06ex2 model.Calibration results reveal that compared with the CPB06ex2 yield criterion with equal quantity of coefficients,the M_CPB06 criterion exhibits certain advancement,and meanwhile the M_CPB06ev model can relatively accurately predict the change of the yield locus with increase of the plastic strain.Finally,the M_CPB06ev model was developed through UMAT in LS-DYNA.Finite element simulations using the subroutine were conducted on the specimens of different angles to the rolling direction under tension and compression.Simulation results were highly consistent with the experimental results,demonstrating a good reliability and accuracy of the developed subroutine.展开更多
BACKGROUNDβ-ketothiolase deficiency(β-KTD)is an inherited disease,and insufficient attention has been paid to imageology due to its lower morbidity.Therefore,few lesions outside the basal ganglia have been found bef...BACKGROUNDβ-ketothiolase deficiency(β-KTD)is an inherited disease,and insufficient attention has been paid to imageology due to its lower morbidity.Therefore,few lesions outside the basal ganglia have been found before,and the persistent pathological changes have rarely been reported.CASE SUMMARY A 10-mo-old Chinese female patient with a free previous medical history but with poor physical and athletic development had received the haemophilus influenzae vaccine and then developed a low fever 2 d prior.She was initially diagnosed with severe brain injury,central respiratory failure,metabolic acidosis complicated with respiratory alkalosis,hyper-IgE,etc.With further examination,a definite diagnosis ofβ-KTD was made.Symptomatic treatment was adopted.Ten days later,the dyspnea was improved evidently and the ventilator was removed,but there were still obvious abnormalities on magnetic resonance imaging(MRI).The lesions mainly invaded the corpus striatum but were not limited to the basal ganglia.Then,the patient’s disease improved and discharged approximately 1 mo later,and the abnormal lesions on MRI had partially improved.However,for about 1 year,the residual irreversible lesions were observed on MRI,the mental and physical development of the patient was obviously regressive,and extra rehabilitation training was needed.CONCLUSION The case highlights the critical importance of one view that the range of lesions in some patients may be more extensive than previously thought in someβ-KTD patients.In addition to biochemical tests,genetic tests and magnetic resonance imaging are not only conducive to quickly diagnosingβ-KTD but also to partially evaluating the short-and long-term outcomes.Moreover,more attention should be paid to the two mutations(c.478 C>G;c.951 C>T)that may be associated with severeβ-KTD.展开更多
Nanofiltration(NF)membranes as high selective separators are appealing for molecular sieving,which still remains a great challenge for the mixed dyes with same charge.In this study,cellulose acetate(CA)membranes were ...Nanofiltration(NF)membranes as high selective separators are appealing for molecular sieving,which still remains a great challenge for the mixed dyes with same charge.In this study,cellulose acetate(CA)membranes were firstly aminated by ethylene imine polymer(PEI),and then the thin film of metal organic frameworks(MOFs)were constructed onto aminated CA membrane through forward-diffusion,slow crystallization and in situ growth of Fe Co-Prussian blue(FeCo-PB)crystallization layers.The designed PB@CA composite NF membrane shows an ideal rejection for Congo red(CR)/methyl orange(MO)mixture solution,with 99.7%±0.2%for CR and 33.5%±2%for MO.In addition,the composite NF membrane demonstrated good efficiency for photocatalytic degradation of organic fouling(permeability recovery ratio was up to 92%)due to the active FeCo-PB micro-cubes.Thus,this work provides a practical strategy to prepare MOFs mediated thin film composite nanofiltration membrane for precise molecular sieving and catalytic antifouling performances.展开更多
OBJECTIVE:To investigate the mechanism of Yin deficiency syndrome(YDS) by analyzing the liver metabolomic characteristics of three different Yin deficiency rat models METHODS:Following the TCM etiology,for clinical fe...OBJECTIVE:To investigate the mechanism of Yin deficiency syndrome(YDS) by analyzing the liver metabolomic characteristics of three different Yin deficiency rat models METHODS:Following the TCM etiology,for clinical features and pathological manifestations of modern medicine,three kinds of animal models of Yin deficiency were induced and replicated.Totally 48 Sprague-Dawley(SD) male rats were randomly divided into blank group,irritation induced model group,Fuzi-Ganjiang induced model group,and thyroxine-reserpine induced model group.After successful development of model,the ultraperformance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was carried out to detect metabolites in each group.The metabolites of rat liver were analyzed for the characteristics of their biomarkers.The pathway enrichment analysis and metabolic network construction were performed through various online databases including Metabolite Biology Role,Human Metabolome Database,MetaboAnalyst,and Kyoto Encyclopedia of Genes and Genomes.RESULTS:The SD rats in the experimental group showed symptoms like less weight gain,reduced diet and water intake,high body temperature,increased liver and kidney indexes,and abnormal liver and kidney tissue morphology.Moreover,the rats showed high increased levels of serum cyclic adenosine monophosphate,estradiol,alanine transaminase,and aspartate aminotransferase and decreased levels of cyclic guanosinc monophosphate and testosterone.We found four key interrelated metabolic pathways in the liver tissue metabolomics,including the biosynthesis of pantothenic acid and coenzyme A,and metabolism of alpha-linolenic acid metabolism,glycerophospholipid metabolism,and sphingolipid.CONCLUSION:The liver and kidney YDS is closely related to the biosynthesis of pantothenic acid and CoA and abnormal metabolism of α-linolenic acid,glycerophospholipid,and sphingolipid in SD rats.展开更多
Electron donors are widely exploited in visible-light photocatalytic hydrogen production.As a typical electron donor pair and often the first choice for hydrogen production,the sodium sulfide-sodium sulfite pair has b...Electron donors are widely exploited in visible-light photocatalytic hydrogen production.As a typical electron donor pair and often the first choice for hydrogen production,the sodium sulfide-sodium sulfite pair has been extensively used.However,the resultant thiosulfate ions consume the photogenerated electrons to form an undesirable pseudocyclic electron transfer pathway during the photocatalytic process,strongly limiting the solar energy conversion efficiency.Here,we report novel and bioinspired electron donor pairs offering a noncyclic electron transfer pathway that provides more electrons without the consumption of the photogenerated electrons.Compared to the state-of-the-art electron donor pair Na_(2)S-Na_(2)SO_(3),these novel Na_(2)S-NaH_(2)PO_(2)and Na_(2)S-NaNO_(2)electron donor pairs enable an unprecedented enhancement of up to 370%and 140%for average photocatalytic H_(2)production over commercial CdS nanoparticles,and they are versatile for a large series of photocatalysts for visible-light water splitting.The discovery of these novel electron donor pairs can lead to a revolution in photocatalysis and is of great significance for industrial visible-light-driven H_(2)production.展开更多
In situ and continuous monitoring of electrochemical activity is key to understanding and evaluating the operation mechanism and efficiency of energy storage devices.However,this task remains challenging.For example,t...In situ and continuous monitoring of electrochemical activity is key to understanding and evaluating the operation mechanism and efficiency of energy storage devices.However,this task remains challenging.For example,the present methods are not capable of providing the real-time information about the state of charge(SOC)of the energy storage devices while in operation.To address this,a novel approach based on an electrochemical surface plasmon resonance(SPR)optical fiber sensor is proposed here.This approach offers the capability of in situ comprehensive monitoring of the electrochemical activity(the electrode potential and the SOC)of supercapacitors(used as an example).The sensor adopted is a tilted fiber Bragg grating imprinted in a commercial single-mode fiber and coated with a nanoscale gold film for high-efficiency SPR excitation.Unlike conventional“bulk”detection methods for electrode activity,our approach targets the“localized”(sub-μm-scale)charge state of the ions adjacent to the electrode interface of supercapacitors by monitoring the properties of the SPR wave on the fiber sensor surface located adjacent to the electrode.A stable and reproducible correlation between the real-time charge–discharge cycles of the supercapacitors and the optical transmission of the optical fiber has been found.Moreover,the method proposed is inherently immune to temperature cross-talk because of the presence of environmentally insensitive reference features in the optical transmission spectrum of the devices.Finally,this particular application is ideally suited to the fundamental qualities of optical fiber sensors,such as their compact size,flexible shape,and remote operation capability,thereby opening the way for other opportunities for electrochemical monitoring in various hard-to-reach spaces and remote environments.展开更多
基金financially supported by the National Natural Science Foundation of China(5217130394)the Natural Science Foundation of Shaanxi(2019KJXX-099,2020YZ0037,2019JLZ-09 and 2019QYPY-194)+2 种基金the Fundamental Research Funds for the Central Universities(3102019JC005)Key R&D Program of Shaanxi(No.2019ZDLGY04-05)the Development and Industrialization Fund(2020KJRC0120)。
文摘The practical deployment of metallic anodes in the energy-dense batteries is impeded by the thermodynamically unstable interphase in contact with the aprotic electrolyte,structural collapse of the substrates as well as their insufficient affinity toward the metallic deposits.Herein,the mechanical flexible,lightweight(1.2 mg cm^(−2))carbon nanofiber scaffold with the monodispersed,ultrafine Sn_(4)P_(3) nanoparticles encapsulation(Sn_(4)P_(3)NPs@CNF)is proposed as the deposition substrate toward the high-areal-capacity sodium loadings up to 4 mAh cm^(−2).First-principles calculations manifest that the alloy intermediates,namely the Na_(15)Sn_(4) and Na_(3)P matrix,exhibit the intimate Na affinity as the“sodiophilic”sites.Meanwhile,the porous CNF regulates the heterogeneous alloying process and confines the deposit propagation along the nanofiber orientation.With the precise control of pairing mode with the NaVPO4F cathode(8.7 mg cm^(−2)),the practical feasibility of the Sn_(4)P_(3) NPs@CNF anode(1^(*)Na excess)is demonstrated in 2 mAh single-layer pouch cell prototype,which achieves the 95.7%capacity retention for 150 cycles at various mechanical flexing states as well as balanced energy/power densities.
文摘In view of the shortcomings of poor temperature resistance, poor pumpability and poor pressure-bearing capacity of commonly used gel plugging materials, polyacrylamide (HPAM) and N,N-methylene bisacrylamide (BIS) were selected for crosslinking and compounding to make a new type of gel plugging material with high temperature and pressure resistance. The compressive strength and yield stress were measured by inverted observation method to evaluate the gel strength. The anti-temperature, anti-pressure, anti-dilution and gel-breaking properties of the gel were evaluated. Finally, 71 type high temperature and high pressure water loss instrument and high temperature and high pressure filter with slit plate were used to evaluate the plugging capacity of gel plugging agent. The experimental results show that the new gel plugging system between 100°C - 120°C, gelation time can be controlled at about 5 h;it has strong temperature resistance, compression resistance, dilution resistance and gel breaking performance. In the face of permeability and fracture leakage simulation experiments, when the ambient temperature below 120°C, pressure within 5 MPa, the filter loss of gel plugging agent is far less than the market two conventional plugging agent, has excellent plugging performance.
文摘In complex strata, oil-based drilling fluid is the preferred drilling fluid system, but its preparation cost is high, and there are hidden safety risks. Therefore, the new progress of high-performance anti-collapse water-based drilling fluid at home and abroad is analyzed. It is difficult to prevent and control the well collapse. Once the well wall instability problem occurs, it will often bring huge economic losses to the enterprises, and the underground safety accidents will occur. In order to ensure the stability of the well wall and improve the downhole safety, the key treatment agent of water-based collapse drilling fluid is selected, the anti-collapse drilling fluid system is formulated, the evaluation method of drilling fluid prevention performance is established, and a set of water-based drilling fluid system suitable for easy to collapse strata in China is selected to ensure the downhole safety. The development trend of high performance anti-collapse water-based drilling fluid is expected to provide a reference for the research of high performance anti-collapse water-based drilling fluid system and key treatment agent.
文摘This project is explaining a laboratory development of a solid free drilling fluid formula that could be potentially used in tight gas reservoirs. The configuration of the weak gel fluid WGL-1, which is resistant to high temperature and high salt, was tested, and concluded that its gelling properties, salt and temperature resistance, and environmental protection were all in line with industry requirements. The final drilling fluid formula was developed as: water + (0.3% ~ 0.5%) NaOH + 5% KCl + 2% WGL-1 + 5% NaCl + (1.0% ~ 2.0%) HBFR Anti-high temperature fluid loss agent + 2% Polyol + (1.5% ~ 2.0%) SDL-1 Lubricant + 0.4% A4O1. The performance of the liquid was tested for temperature resistance, inhibition, gas formation protection effect, plugging performance, and static settlement stability. It was concluded that the temperature resistance performance is satisfied at 150°C, and the cuttings recovery rate is as high as 96.78%. It has good performance in inhibiting water dispersion and swelling of cuttings. The permeability recovery value reaches 88.9%, which meets the requirements of gas formation protection. The SSSI value shows that its settlement stability is good;under high temperature and high pressure, its sealing performance is good. This drilling fluid system has achieved the expected results and laid a foundation for further promoting the development of solid-free drilling fluid systems. The future development direction of solid-free drilling fluids is pointed out, to the improvement of properties to be applied in high temperature environment and have high salt resistance capacity.
基金supported by the National Natural Science Foundation of China,No.81171178
文摘Myelin-associated glycoprotein(MAG) inhibits the growth of neurites from nerve cells. Extraction and purification of MAG require complex operations; therefore, we attempted to determine whether commercially available MAG-Fc can replace endogenous MAG for research purposes. Immunofluorescence using specific antibodies against MAG, Nogo receptor(NgR) and paired immunoglobulin-like receptor B(PirB) was used to determine whether MAG-Fc can be endocytosed by neuro-2a cells. In addition, neurite outgrowth of neuro-2a cells treated with different doses of MAG-Fc was evaluated. Enzyme linked immunosorbent assays were used to measure RhoA activity. Western blot assays were conducted to assess Rho-associated protein kinase(ROCK) phosphorylation. Neuro-2a cells expressed NgR and PirB, and MAG-Fc could be endocytosed by binding to NgR and PirB. This activated intracellular signaling pathways to increase RhoA activity and ROCK phosphorylation, ultimately inhibiting neurite outgrowth. These findings not only verify that MAG-Fc can inhibit the growth of neural neurites by activating RhoA signaling pathways, similarly to endogenous MAG, but also clearly demonstrate that commercial MAG-Fc is suitable for experimental studies of neurite outgrowth.
基金financially supported by Natural Science Foundation of Ningbo City(2018A610026)Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars(LR20E030002)+1 种基金Ten thousand plan-high level talents special support plan of Zhejiang province,China(ZJWR0108020)Youth Innovation Promotion Association of Chinese Academy of Science(2014258)。
文摘Precluding the excessive lipoproteins from plasma rapidly and effectively is highly needed for biomedical detection and reducing plasma product scrap in blood donation stations.The current centrifugation procedure is high-cost and time-consuming.Herein,we fabricated an anionic microfiltration polyethersulfone(PES)membrane modified by interface swelling and implanting of acrylic acid(AA)for screening out large particle lipoprotein chylomicron(CM)and adsorbing cationic very low-density lipoproteins(VLDL).To improve the separation efficiency,a two-stage filtration through carboxylated polyethersulfone microfiltration membranes with the mean pore size of 0.45 and 0.22μm respectively were conducted.Attenuated total reflection Fourier transform infrared technique(ATR-FTIR),water contact angle(WCA),Zeta potential and scanning electron microscope(SEM)were employed to characterize the modified membrane.To test the effectiveness of this membrane,plasma flux and concentration variation of plasma components were examined to study the purification effectiveness.Furthermore,the hemocompatibility of modified membranes was tested to confirm its practicability on bloodcontacting materials.The carboxylated polyethersulfone microfiltration membrane shows its promising potential application to purify chylous plasma.
基金Beijing Natural Science Foundation(No.L201010)the United Fund of Ministry of Education for Equipment Pre-Research(Grant No.6141A02033121)National Natural Science Foundation of China(Grant No.51975041).
文摘A novel yield criterion based on CPB06 considering anisotropic and tension-compression asymmetric behaviors of magnesium alloys was derived and proposed(called M_CPB06).This yield criterion can simultaneously predict the yield stresses and the Lankford ratios at different angles(if any)under uniaxial tension,compression,equal-biaxial and equal-compression conditions.Then,in order to further describe the anisotropic strain-hardening characteristics of magnesium alloy,the proposed M_CPB06 criterion was further evolved to the M_CPB06ev model by expressing the parameters of the M_CPB06 model as functions of the plastic strain.As the model was developed,the stresses and Lankford ratios of AZ31B and ZK61M magnesium alloys at different angles under tensile,compressive and through-thickness compressive conditions were used to calibrate the M_CPB06/M_CPB06ev and the existing CPB06ex2 model.Calibration results reveal that compared with the CPB06ex2 yield criterion with equal quantity of coefficients,the M_CPB06 criterion exhibits certain advancement,and meanwhile the M_CPB06ev model can relatively accurately predict the change of the yield locus with increase of the plastic strain.Finally,the M_CPB06ev model was developed through UMAT in LS-DYNA.Finite element simulations using the subroutine were conducted on the specimens of different angles to the rolling direction under tension and compression.Simulation results were highly consistent with the experimental results,demonstrating a good reliability and accuracy of the developed subroutine.
文摘BACKGROUNDβ-ketothiolase deficiency(β-KTD)is an inherited disease,and insufficient attention has been paid to imageology due to its lower morbidity.Therefore,few lesions outside the basal ganglia have been found before,and the persistent pathological changes have rarely been reported.CASE SUMMARY A 10-mo-old Chinese female patient with a free previous medical history but with poor physical and athletic development had received the haemophilus influenzae vaccine and then developed a low fever 2 d prior.She was initially diagnosed with severe brain injury,central respiratory failure,metabolic acidosis complicated with respiratory alkalosis,hyper-IgE,etc.With further examination,a definite diagnosis ofβ-KTD was made.Symptomatic treatment was adopted.Ten days later,the dyspnea was improved evidently and the ventilator was removed,but there were still obvious abnormalities on magnetic resonance imaging(MRI).The lesions mainly invaded the corpus striatum but were not limited to the basal ganglia.Then,the patient’s disease improved and discharged approximately 1 mo later,and the abnormal lesions on MRI had partially improved.However,for about 1 year,the residual irreversible lesions were observed on MRI,the mental and physical development of the patient was obviously regressive,and extra rehabilitation training was needed.CONCLUSION The case highlights the critical importance of one view that the range of lesions in some patients may be more extensive than previously thought in someβ-KTD patients.In addition to biochemical tests,genetic tests and magnetic resonance imaging are not only conducive to quickly diagnosingβ-KTD but also to partially evaluating the short-and long-term outcomes.Moreover,more attention should be paid to the two mutations(c.478 C>G;c.951 C>T)that may be associated with severeβ-KTD.
基金International Partnership Program of Chinese Academy of Sciences-Grand Challenges(No.181GJHZ2022038GC)Key Research and Development Program of Zhejiang Province,China(No.2021C03170)+4 种基金Ten thousand plan-high level talents special support plan of Zhejiang province,China(No.ZJWR0108020)National Natural Science Foundation of China(No.51973230)Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars(No.LR20E030002)“Science and Technology Innovation 2025”Major Project of Ningbo(No.2020Z105)Youth Innovation Promotion Association of Chinese Academy of Science(No.2014258).
文摘Nanofiltration(NF)membranes as high selective separators are appealing for molecular sieving,which still remains a great challenge for the mixed dyes with same charge.In this study,cellulose acetate(CA)membranes were firstly aminated by ethylene imine polymer(PEI),and then the thin film of metal organic frameworks(MOFs)were constructed onto aminated CA membrane through forward-diffusion,slow crystallization and in situ growth of Fe Co-Prussian blue(FeCo-PB)crystallization layers.The designed PB@CA composite NF membrane shows an ideal rejection for Congo red(CR)/methyl orange(MO)mixture solution,with 99.7%±0.2%for CR and 33.5%±2%for MO.In addition,the composite NF membrane demonstrated good efficiency for photocatalytic degradation of organic fouling(permeability recovery ratio was up to 92%)due to the active FeCo-PB micro-cubes.Thus,this work provides a practical strategy to prepare MOFs mediated thin film composite nanofiltration membrane for precise molecular sieving and catalytic antifouling performances.
基金Supported by Jiangxi University of Chinese Medicine,Jiangxi Province Double First-Class Discipline of Traditional Chinese Medicine Construction Project (No. JXSYLXK-ZHYI026)Supported by Science and Technology Program of Jiangxi Provincial Health and Health Commission (SKJP220210415):Exploring the Formation Mechanism of Liver and Kidney Yin Deficiency Based on Animal Model and MetabolomicsSupported by National TCM Leading Talent Support Program of the State Administration of TCM-Qi Huang Scholar (No. 284, China TCM people’s teaching letter [2018])。
文摘OBJECTIVE:To investigate the mechanism of Yin deficiency syndrome(YDS) by analyzing the liver metabolomic characteristics of three different Yin deficiency rat models METHODS:Following the TCM etiology,for clinical features and pathological manifestations of modern medicine,three kinds of animal models of Yin deficiency were induced and replicated.Totally 48 Sprague-Dawley(SD) male rats were randomly divided into blank group,irritation induced model group,Fuzi-Ganjiang induced model group,and thyroxine-reserpine induced model group.After successful development of model,the ultraperformance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was carried out to detect metabolites in each group.The metabolites of rat liver were analyzed for the characteristics of their biomarkers.The pathway enrichment analysis and metabolic network construction were performed through various online databases including Metabolite Biology Role,Human Metabolome Database,MetaboAnalyst,and Kyoto Encyclopedia of Genes and Genomes.RESULTS:The SD rats in the experimental group showed symptoms like less weight gain,reduced diet and water intake,high body temperature,increased liver and kidney indexes,and abnormal liver and kidney tissue morphology.Moreover,the rats showed high increased levels of serum cyclic adenosine monophosphate,estradiol,alanine transaminase,and aspartate aminotransferase and decreased levels of cyclic guanosinc monophosphate and testosterone.We found four key interrelated metabolic pathways in the liver tissue metabolomics,including the biosynthesis of pantothenic acid and coenzyme A,and metabolism of alpha-linolenic acid metabolism,glycerophospholipid metabolism,and sphingolipid.CONCLUSION:The liver and kidney YDS is closely related to the biosynthesis of pantothenic acid and CoA and abnormal metabolism of α-linolenic acid,glycerophospholipid,and sphingolipid in SD rats.
基金This work is financially supported by the National Key R&D Program of China(grant nos.2016YFA0202602 and 2021YFE0115800)the National Natural Science Foundation of China(grant nos.U20A20122 and 52103285)+3 种基金the Program of Introducing Talents of Discipline to Universities-Plan 111 from the Ministry of Science and Technology and the Ministry of Education of China(grant no.B20002)the“Algae Factory”European Horizon 2020 Program financed by FEDER and Wallonia Region of Belgium(grant no.1610187)the“DepollutAir”of Interreg V France-Wallonie-Vlaanderen and the Natural Science Foundation of Hubei Province(grant nos.2018CFB242 and 2020CFB416)the Youth Innovation Research Fund Project of the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing.T.H.acknowledges support from the Royal Academy of Engineering through a Research Fellowship(Graphlex).We also thank Prof.Pierre Van Cutsem,Department of Biology,University of Namur for his advice.
文摘Electron donors are widely exploited in visible-light photocatalytic hydrogen production.As a typical electron donor pair and often the first choice for hydrogen production,the sodium sulfide-sodium sulfite pair has been extensively used.However,the resultant thiosulfate ions consume the photogenerated electrons to form an undesirable pseudocyclic electron transfer pathway during the photocatalytic process,strongly limiting the solar energy conversion efficiency.Here,we report novel and bioinspired electron donor pairs offering a noncyclic electron transfer pathway that provides more electrons without the consumption of the photogenerated electrons.Compared to the state-of-the-art electron donor pair Na_(2)S-Na_(2)SO_(3),these novel Na_(2)S-NaH_(2)PO_(2)and Na_(2)S-NaNO_(2)electron donor pairs enable an unprecedented enhancement of up to 370%and 140%for average photocatalytic H_(2)production over commercial CdS nanoparticles,and they are versatile for a large series of photocatalysts for visible-light water splitting.The discovery of these novel electron donor pairs can lead to a revolution in photocatalysis and is of great significance for industrial visible-light-driven H_(2)production.
基金the support of the National Natural Science Foundation-Excellent Youth Foundation of China(No.61722505)the Guangdong Youth Science and Technology Innovation Talents of China(No.2014TQ01X539)+5 种基金the Guangzhou Key Collaborative Innovation Foundation of China(No.2016201604030084)the support of the Natural Science Foundation of China(51772135)the Ministry of Education of China(6141A02022516)the Natural Science Foundation of Guangdong Province(2014A030306010)the support of the Natural Sciences and Engineering Research Council of Canada(No.RGPIN 2014-05612)the Canada Research Chairs Program(No.950-217783).
文摘In situ and continuous monitoring of electrochemical activity is key to understanding and evaluating the operation mechanism and efficiency of energy storage devices.However,this task remains challenging.For example,the present methods are not capable of providing the real-time information about the state of charge(SOC)of the energy storage devices while in operation.To address this,a novel approach based on an electrochemical surface plasmon resonance(SPR)optical fiber sensor is proposed here.This approach offers the capability of in situ comprehensive monitoring of the electrochemical activity(the electrode potential and the SOC)of supercapacitors(used as an example).The sensor adopted is a tilted fiber Bragg grating imprinted in a commercial single-mode fiber and coated with a nanoscale gold film for high-efficiency SPR excitation.Unlike conventional“bulk”detection methods for electrode activity,our approach targets the“localized”(sub-μm-scale)charge state of the ions adjacent to the electrode interface of supercapacitors by monitoring the properties of the SPR wave on the fiber sensor surface located adjacent to the electrode.A stable and reproducible correlation between the real-time charge–discharge cycles of the supercapacitors and the optical transmission of the optical fiber has been found.Moreover,the method proposed is inherently immune to temperature cross-talk because of the presence of environmentally insensitive reference features in the optical transmission spectrum of the devices.Finally,this particular application is ideally suited to the fundamental qualities of optical fiber sensors,such as their compact size,flexible shape,and remote operation capability,thereby opening the way for other opportunities for electrochemical monitoring in various hard-to-reach spaces and remote environments.