Correlation study between CT perfusion parameters of non-small cell lung cancer and angiogenesis, cell proliferation as well as tumor load

Objective:To study the correlation between CT perfusion parameters of non-small cell lung cancer and angiogenesis, cell proliferation as well as tumor load.Methods: Patients diagnosed with non-small cell lung cancer in our hospital between May 2012 and December 2015 were selected, CT perfusion was used to measure the blood volume (BV), blood flow (BF) and time to peak (TTP) of lung cancer lesions and unaffected-side lung tissue, and the lung cancer tissue and para-carcinoma tissue were collected to determine the expression of angiogenesis and cell proliferation molecules.Results:BV and BF of non-small cell lung cancer tissue were significantly higher than those of unaffected-side lung tissue while TTP was significantly shorter than that of unaffected-side lung tissue;PCDGF, bFGF, FGFR, VEGF, VEGFR, TCF3, Skp2, Livin and Survivin expression in non-small cell lung cancer tissue were significantly higher than those in para-carcinoma tissue, positively correlated with BV and BF, and negatively correlated with TTP.Conclusion:CT perfusion parameters BV, BF and TTP are closely related to the expression of angiogenesis molecules and cell proliferation molecules in non-small cell lung cancer lesions, and are valuable for the assessment of angiogenesis and cell proliferation.