科研试验数据跨域归档研究

文章提出了一种跨域场景下的科研试验数据在线归档方法,从数据处理、数据传输、数据管理和数据安全四个方面优化归档流程,在克服传统方法弊端的同时,显著提升了科研试验数据的归档质量和归档效率。此外,在“工控网-办公网”典型跨域入库场景下的方法实践验证了研究所提出方法的高效性,为跨域场景下的科研试验数据归档提供了良好参考案例。

Study on Path Selection and Implementation Effect of Counselors in College Students’Career Planning Education

Under the background of a severe job market and fierce talent competition,the career planning education of college students is of great importance.In this study,a combination of quantitative and qualitative research methods was used;500 students in Shenzhen Polytechnic of Information Technology were surveyed by questionnaire,and 40 counselors were interviewed in depth to comprehensively analyze the role and practical effect of counselors in career planning education.The research showed that the role positioning of counselors includes the guide of students’career development,emotional support,and job-hunting strategy,and the specific path selection involves the strengthening of professional knowledge,the construction of interpersonal relationship networks,and personalized counseling.Based on the survey and interview data,this paper constructed a model for enhancing the role of counselors in career planning education and put forward a set of targeted work paths.

森林防灭火工作现状分析——以云南西双版纳国家级自然保护区曼稿子保护区为例

针对云南西双版纳国家级自然保护区曼稿子保护区森林防灭火工作存在的问题展开研究。介绍了曼稿子保护区概况,分析了该保护区森林防灭火工作现状,阐述了存在的问题,并提出强化措施,旨在为曼稿子保护区森林防灭火工作提供参考,以更好地保护该区域的生态安全和生物多样性。

A bi-population immune algorithm for weapon transportation support scheduling problem with pickup and delivery on aircraft carrier deck

The weapon transportation support scheduling problem on aircraft carrier deck is the key to restricting the sortie rate and combat capability of carrier-based aircraft.This paper studies the problem and presents a novel solution architecture.Taking the interference of the carrier-based aircraft deck layout on the weapon transportation route and precedence constraint into consideration,a mixed integer formulation is established to minimize the total objective,which is constituted of makespan,load variance and accumulative transfer time of support unit.Solution approach is developed for the model.Firstly,based on modeling the carrier aircraft parked on deck as convex obstacles,the path library of weapon transportation is constructed through visibility graph and Warshall-Floyd methods.We then propose a bi-population immune algorithm in which a population-based forward/backward scheduling technique,local search schemes and a chaotic catastrophe operator are embedded.Besides,the randomkey solution representation and serial scheduling generation scheme are adopted to conveniently obtain a better solution.The Taguchi method is additionally employed to determine key parameters of the algorithm.Finally,on a set of generated realistic instances,we demonstrate that the proposed algorithm outperforms all compared algorithms designed for similar optimization problems and can significantly improve the efficiency,and that the established model and the bi-population immune algorithm can effectively respond to the weapon support requirements of carrier-based aircraft under different sortie missions.

Cold plasma-activated Cu-Co catalysts with CN vacancies for enhancing CO_(2)electroreduction to low-carbon alcohol

Electrocatalytic CO_(2)reduction reaction to low-carbon alcohol is a challenging task,especially high selectivity for ethanol,which is mainly limited by the regulation of reaction intermediates and subsequent C–C coupling.A Cu-Co bimetallic catalyst with CN vacancies is successfully developed by H_(2)cold plasma toward a high-efficiency CO_(2)RR into low-carbon alcohol.The Cu-Co PBA-V_(CN)(Prussian blue analogues with CN vacancies)electrocatalyst yields methanol and ethanol as major products with a total low-carbon alcohol FE of 83.8%(methanol:39.2%,ethanol:44.6%)at-0.9 V vs.RHE,excellent durability(100 h)and a small onset potential of-0.21 V.ATR-SEIRAS(attenuated total internal reflection surface enhanced infrared absorption spectroscopy)and DFT(density functional theory)reveal that the steric hindrance of V_(CN)can enhance the CO generation from*COOH,and the C–C coupling can also be increased by CO spillover on uniformly dispersed Cu atoms.This work provides a strategy for the design and preparation of electrocatalysts for CO_(2)RR into low-carbon alcohol products and highlights the impact of catalyst steric hindrance to catalytic performance.

Nitrogen cold plasma treatment stabilizes Cu^(0)/Cu^(+) electrocatalysts to enhance CO_(2) to C2 conversion

Cu-based materials are ideal catalysts for CO_(2) electrocatalytic reduction reaction(CO_(2)RR) into multicarbon products.However,such reactions require stringent conditions on local environments of catalyst surfaces,which currently are the global pressing challenges.Here,a stabilized activation of Cu^(0)/Cu^(+)-onAg interface by N_(2) cold plasma treatment was developed for improving Faradaic efficiency(FE) of CO_(2)RR into C2 products.The resultant Ag@Cu-CuN_x exhibits a C2 FE of 72% with a partial current density of-14.9 mA cm^(-2) at-1.0 V vs.RHE(reversible hydrogen electrode).Combining density functional theory(DFT) and experimental investigations,we unveiled that Cu^(0)/Cu^(+) species can be co ntrollably tu ned by the incorporation of nitrogen to form CuN_x on Ag surface,i.e.,Ag@Cu-CuN_x.This strategy enhances ^(*)CO intermediates generation and accelerates C-C coupling both thermodynamically and kinetically.The intermediates O^(*)C^(*)CO,^(*)COOH,and ^(*)CO were detected by in-situ attenuated total internal reflection surface enhanced infrared absorption spectroscopy(ATR-SEIRAS).The uncovered CO_(2)RR-into-C2 products were carried out along CO_(2)→^(*)COOH→^(*)CO→O^(*)C^(*)CO→^(*)C_(2)H_(3)O→^(*)C_(2)H_(4)O→ C_(2)H_(5)OH(or ^(*)C_(2)H_(3)O→^(*)O+C_(2)H_(4)) paths over Ag@Cu-CuN_x electrocatalyst.This work provides a new approach to design Cu-based electrocatalysts with high-efficiency,mild condition,and stable CO_(2)RR to C2 products.

如何做好军工科研单位科技档案的利用与保密管理

如何做到保障科技档案安全保密的同时,又能提供科技档案的有效利用,是军工科研单位档案工作者面临的普遍问题。本文在分析军工科研单位保密管理和科技档案利用管理现状和特点的基础上,提出了通过多种方式将保密管理融入科技档案管理的业务流程中,从而实现既能为科研人员提供最大程度的档案利用,又能满足保密安全的要求,达到最大程度发挥科技档案价值的目的。

Idiopathic mesenteric phlebosclerosis associated with long-term use of medical liquor:Two case reports and literature review

A 62-year-old woman was admitted to our hospital in2011 because of recurrent abdominal pain,nausea and constipation for six months.Computed tomography enterography(CTE)showed tortuous thread-like calcifications in the ileocolic vein and right colic vein,while colonoscopy revealed purple-blue mucosa extending from the cecum to the splenic flexure.Based on the results of these tests,the patient was diagnosed with idiopathic mesenteric phlebosclerosis(IMP).She had a history of Chinese medical liquor intake for one and a half years and her symptoms subsided after conservative treatment.In 2013,a 63-year-old male patient who presented with recurrent lower right abdominal pain,bloating,melena and diarrhea for fifteen months was admitted to our institution.Colonoscopy and CTE led to the diagnosis of IMP.He also used Chinese medical liquor for approximately 12 years.The patient underwent total colectomy and the postoperative course was uneventful.We searched for previously published reports on similar cases and analyzed the clinical data of 50 cases identified in PubMed.As some of these patients admitted use of Chinese medicines,we hypothesize that Chinese medicines may play a role in the pathogenesis of IMP.

急诊内镜手术对急性梗阻性化脓性胆管炎患者疗效及并发症发生率的影响

目的研究急诊内镜手术对急性梗阻性化脓性胆管炎(AOSC)患者疗效及并发症发生率的影响。方法回顾性分析AOSC患者的临床资料,对照组采取常规的手术方法治疗,研究组采用急诊内镜手术治疗。将两组患者的炎性因子表达、术后并发症发生率、住院时间、手术时间、肠胃恢复时间、腹部疼痛恢复时间和生命质量评分(QOL)进行比较。结果研究组患者的炎性因子表达明显低于对照组患者(P<0.05);研究组术后并发症发生率低于对照组(P<0.05);研究组的住院时间和手术时间短于对照组(P<0.05);研究组的肠胃恢复时间和腹部疼痛恢复时间少于对照组(P<0.05);对照组QOL评分低于研究组(P<0.05)。结论急诊内镜手术治疗AOSC具有疗效佳且并发症少的优点,优于传统的手术治疗。

Fruit and vegetable consumption and its relation to risk of asthenopia among Chinese college students

AIM： To investigate the associations between fruit and vegetable consumption and risk of asthenopia among Chinese college students. METHODS： A total of 1022 students were selected from five universities by a multi-stage stratified cluster sampling method. They were surveyed via a self-administered questionnaire including socio-demographic features, dietary and lifestyle habits, eye-related symptoms, eye care habits and history of diseases. Ascertainment of asthenopia was based on participants＇ subjectively reported symptoms. The associations between fruit and vegetable intake with asthenopia risk were assessed using multivariate logistic regression analysis. RESULTS： There were no significant associations between total fruit and vegetable, total vegetable, or fruit and the risk of asthenopia. Higher intake of dark-green leafy vegetable was likely to be inversely associated with asthenopia risk [odd ratio （OR）： 0.60; 95%CI： 0.37-0.97; Ptrend=0.21] after controlling for nondietary and dietary risk factors. Stratified analysis showed that the inverse association between dark-green leafy vegetable intake and asthenopia risk was limited to participants with suboptimal eyesight （OR： 0.45; 95%CI： 0.25-0.82; Ptrend=0.05）, wearing glasses （OR： 0.35; 95%CI： 0.17-0.72; Ptrend=0.03） or using computer ≥3h/d （OR： 0.48; 95%CI： 0.25-0.93; Ptrend=0.08）. CONCLUSION： A higher consumption of dark-green leafy vegetable is associated with a lower asthenopia risk among college students with suboptimal eyesight and poor eye care habits.

Effects of the crystallization time on the mesoporous structure,texture, morphology and styrene oxidation performances of V-MCM-41

The new V-MCM-41 molecular sieves with good ordered hexagonal mesoporous structure and crystallinity were synthesized through in-situ hydrothermal preparation method. The effects of the crystallization time were discussed. The synthesized samples were characterized by X-ray diffraction, N2adsorption/desorption, Fourier transformed infrared and scanning electron microscopy. The different structures, textures, morphologies of V-MCM-41 obtained with different crystallization times were observed and analyzed on the basis of the characterized results. The results showed that the V-MCM-41 molecular sieve obtained at 110?°C for 48?h crystallization times was of good spherical morphology, ordered hexagonal structure, most uniform pore size distribution and high surface area compared with other samples. Meanwhile, the V-MCM-41 molecular sieve with the high skeleton Si condensation and the good crystallinity was obtained. The heteroatom could be incorporated into MCM-41 framework with increasing crystallization times, which was beneficial to improve the catalytic activity and selectivity of pure siliceous MCM-41. The V-MCM-41 showed the good catalytic selectivity in catalytic oxidation of styrene using hydrogen peroxide, and the selectivity of the benzaldehyde and phenylacetic acid reached 30.68% and 49.44%, respectively. ? 2016

高效液相色谱法同时测定化妆品中16种防腐剂、防晒剂和去屑剂

建立了高效液相色谱法同时测定化妆品中防腐剂、防晒剂和去屑剂共16种组分的分析方法。样品经甲醇提取后,使用Eclipse Plus C18(250 mm×4.6 mm×5μm)色谱柱,以甲醇-0.5 mmol/L EDTA-2Na水溶液(pH=3.06)为流动相,梯度洗脱。采用二极管阵列检测器在多波长下同时测定化妆品中10种防腐剂、4种防晒剂和2种去屑剂。该方法的相对标准偏差为2.2%~6.5%,回收率为90.9%~109.7%,16种组分在相应的线性范围内线性关系良好,相关系数范围为0.999 0~0.999 7,该方法具有较高的准确度和精密度,能满足实际检测需求,为实验室检测提供新的技术支持。

Serum Helicobacter pylori Kat A and Ahp C antibodies as novel biomarkers for gastric cancer

AIM: To investigate catalase(Kat A) and alkyl hydroperoxide reductase(Ahp C) antibodies of Helicobacter pylori as biomarkers for gastric cancer(GC).METHODS: This study included 232 cases and 264 controls. Recombinant Kat A and Ahp C proteins were constructed and the levels of antibodies were tested by indirect enzyme-linked immunosorbent assay(ELISA). Logistic regression was applied to analyze the relationships between Kat A, Ahp C and GC. The χ2 trend test was used to evaluate the dose-response relationships between serum Kat A and Ahp C antibody levels and GC. Receiver operating characteristic(ROC) curve was used to evaluate the screening accuracy of Kat A and Ahp C as biomarkers. Combined analysis was used to observe screening accuracy of predictors for GC.RESULTS: In all subjects, the association between Kat A and Ahp C and GC risk was significant(P < 0.001) with odds ratio(OR) = 12.84(95%CI: 7.79-21.15)and OR = 2.4(95%CI: 1.55-3.73), respectively. Kat A and Ahp C antibody levels were strongly related to GC risk with a dose-dependent effect(P for trend < 0.001). The area under the ROC(AUC) for Kat A was 0.806, providing a sensitivity of 66.81% and specificity of 86.36%; and the AUC for Ahp C was 0.615, with a sensitivity of 75.65% and specificity of 45.49%. The AUC was 0.906 for Kat A and flagella protein A(Fla A) combined analysis.CONCLUSION: Serum Kat A and Ahp C antibodies are associated with GC risk and Kat A may serve as a biomarker for GC. Kat A/Fla A combined analysis improved screening accuracy.

Effect of dendritic cell/cytokine-induced killer cell immunobiological cancer therapy combined with adjuvant chemotherapy in patients with triple-negative breast cancer

Objective The aim of the present study was to investigate the effect of dendritic cell(DC)/cytokine-induced killer cell(CIK) immunobiological cancer therapy in patients with triple-negative breast cancer(TNBC) who underwent adjuvant chemotherapy. Methods From January 2010 to October 2013, 120 patients with postoperative TNBC were recruited and included in the study. Patients were enrolled in one of two groups according to whether they accepted DC/CIK immunobiological cancer therapy during adjuvant chemotherapy; the patients in the DC/CIK group underwent adjuvant chemotherapy combined with DC/CIK immunobiological cancer therapy, and the control group underwent adjuvant chemotherapy alone. When six cycles of adjuvant chemotherapy and six cycles of DC/CIK immunobiological cancer therapy had been completed, differences between the two groups with regard to quality of life(Qo L), immunological indicators(CD3, CD4, CD8, and NK cell levels), disease-free survival(DFS), and side effects of chemotherapy and DC/CIK treatment were evaluated.Results In the DC/CIK group, the proportion of NK cells and CD3+ and CD4+ T-cell subgroups significantly increased, and the proportion of CD8+ cells decreased when they were compared before and after DC/CIK therapy(P < 0.05). However, there were no significant changes in the control group. By the final follow-up, DFS of the treatment group and the control group was 38.4 and 34.2 months, respectively. The Qo L improved in the patients treated with chemotherapy plus DC/CIK therapy compared with the patients treated with chemotherapy alone, and the difference between groups was significant(P < 0.05). The side effects of two groups were tolerable and not significantly different between the two groups.Conclusion The DC/CIK treatment had potential benefits for patients with TNBC compared with the control group, and was not associated with any obvious side effects. Therefore, DC/CIK therapy is a safe and effective method for the treatment of TNBC.

自体CIK细胞联合XELOX化疗治疗晚期结直肠癌的随机对照研究(英文)

Objective: To evaluate the efficacy of autologous cytokine-induced killer(CIK) cells transfusion combined with chemotherapy in patients suffered from advanced colorectal cancer. Methods: Sixty untreated patients with advanced colorectal cancer were randomly divided into two groups. The 30 patients in the control group received chemotherapy with the regimen of xeloda plus oxiplatin(XELOX). The 30 patients in the trial group were treated with chemotherapy(XELOX) in combination with autologous CIK cell transfusion. T-lymphocyte subgroups were separated and measured by flow cytometry quality of life(QOL) was determined by EORTC QLQ-C30. The short-term curative effect was evaluated via imaging examinations. The patients' median progression free survival time was estimated by Kaplan-Meier. Results: The T-lymphocyte immune activity was improved in patients received autologous CIK cell transfusion than those treated with chemotherapy alone.The subgroup of CD3+CD56+T lymphocyte was significantly increased(4.28 ± 0.45 vs 10.14 ± 1.02, P = 0.01). Short-term efficacy evaluation revealed that there was no significant difference in terms of objective response rate(ORR) between the two groups, but the disease control rate(DCR) was markedly increased(86.7% vs 56.7%, P = 0.020) in the group treated by chemotherapy plus CIK cells compared to the group treated with chemotherapy alone. The progression free survival time was 8.64 months( 95% CI 6.25-9.75 months) in control group and 10.15 months( 95% CI 7.48-12.52 months) in trial group.Compared to patients in control group, the patients in trial group had significantly longer progression-free survival(P = 0.046).The QOL assessment suggested the QOL in trial group was obviously improved than that in the control group. Compared with the control group, patients treated with autologous CIK cell transfusion scored more in the area of physical function and general health status, while the symptomatic scores in terms of pain, fatigue, nausea and vomiting and diarrhea were significantly reduced. Conclusion: Autologous CIK cell transfusion combined with chemotherapy can effectively enhance the immune activity of T-lymphocytes, prevent disease progression and improve the progression-free survival and QOL in patients with advanced colorectal cancer.

Meta分析在最新乳腺癌系统治疗中的应用(英文)

Meta-analysis is a kind of systematic review,which uses quantitative method to summarize the results.It is a comprehensive evaluation to the findings of previous studies with higher credibility.Recently,it is applied to all areas of scientific research,particularly in the integrated treatment of breast cancer.Currently,breast cancer is known one of the most common malignant tumors,and its incidence is increasing year by year.Therefore,more and more clinical doctors pay attention to the effect of comprehensive treatment for patients with breast cancer.This article mainly collects the results of comprehensive treatment of breast cancer,in which the method of Meta-analysis is applied.In addition,we discuss the latest progress in order to guide the clinical treatment.

Karst Groundwater Management through Science and Education

In Southwestern China, karst covers an area of 540,000 km2, and supports a population of approximately 100 million people. This groundwater can easily become highly polluted without effective management. Sound management of karst areas requires the conscientious participation of citizens including homeowners, planners, government officials, farmers and other land-use decision makers. Lingshui Spring was a good example. A series of educational materials were developed and delivered to the local government, residents, and students. A groundwater polluted accident was tracked as a natural tracer test in a spring to increase understanding of the vulnerability of the area’s karst aquifer. More than 200 people attended the communication and training course on groundwater protection and environmental justice law. Several efforts have appeared as a result, such as a proposal for Lingshui water resources protection that was put forward for the first time by Wuming county political consultative conference.

基于MaxEnt模型的西双版纳保护区曼稿片区印度野牛生境适应性分析保护建议

西双版纳保护区为很多珍稀物种提供了栖身之所,其中的曼稿片区是印度野牛(Bos gaurus)的重要分布区域之一,但是保护区面积小,周边村寨较多,面临着比较大的人口压力,为了保证印度野牛的有效保护,需要基于它们的栖息地要求对保护区和周边的野牛适宜生境开展研究制图,为保护政策提供依据。本研究基于一个年度的红外相机和野外数据收集,利用MaxEnt模型对曼稿保护区和周边区域的野牛适宜生境进行了制图。结果显示,印度野牛喜欢靠近道路、坡度平缓的天然植被,同时,它们的出现与最湿季降雨量有关,印度野牛的适宜生境有61%位于保护区内。基于模型结果,我们建议建立保护区与布龙、纳板河保护区之间的保护廊道。

Systematically optimized topical delivery system for Loperamide hydrochloride: Formulation design,in vitro and in vivo biopharmaceutical evaluation

This study aimed to develop a suitable topical delivery system containing diethylene glycol monoethyl ether(DGME) for Loperamide hydrochloride(Lop). Two factors, three levels CentralComposite design were applied by generating a quadratic polynomial equation to form contour plots and response surface for prediction of responses as two selected independent variables with EtOH-DGME ratio and EtOH concentration. The response variables flux and skin retention were determined in in vitro hairless mouse skin model. The selected optimum formulation was evaluated for the skin transport characteristics by developing dermatokinetic analysis model and the results demonstrated DGME improved the delivery of Lop into skin deep layers, which was further confirmed by confocal laser scanning microscopy(CLSM)study. In vitro skin permeation was found to have triphasic correlation with plasma AUC in the in vivo pharmacokinetic study. The in vitro–in vivo correlation enabled the prediction of pharmacokinetic profile of Lop from in vitro permeation results. Therefore, the optimum formulation capable of enhancing Lop intracutaneous depot could be a candidate for topical delivery of Lop as analgesics.

Glow Discharge Plasma-Assisted Preparation of Nickel-Based Catalyst for Carbon Dioxide Reforming of Methane

一个帮助血浆的方法被采用准备 Ni/γ-Al 2 为甲烷反应改过的二氧化碳的 O 3 催化剂。新奇催化剂常规锻烧催化剂比那些拥有了更高的活动和更好的焦炭抑制性能。完成一样的 CH 4 变换，常规催化剂需要更高的反应温度，比 N 2 的高的大约 50 ° C 对待血浆的催化剂。在评估测试以后，新奇催化剂的释放率为常规催化剂是 1.7% ，与 15.2% 相比。与锻烧的催化剂，一条更小的平均毛孔直径和一个更高特定的表面区域的描述结果不同为对待血浆的催化剂被获得。减小山峰温度和区域的变化显示催化剂 reducibility 被血浆帮助支持。镍的分散显著地也被改进，它对在催化剂表面上控制金属原子的整体尺寸有用。氧化铝的表面性质上的帮助血浆的准备的修正效果支持了催化剂被推测说明吸收公司 2 的集中增加。公司 2 吸附的改进对碳形成的抑制慈悲。在血浆上扔的焦炭数量对待催化剂在常规催化剂上是比那小得多的。