Surface functionalization is generally accepted as one of the most useful methods for endowing better biocompatibility of the cardiovascular implants. Chondroitin sulfate(CS) is a commercial drug applied for preventin...Surface functionalization is generally accepted as one of the most useful methods for endowing better biocompatibility of the cardiovascular implants. Chondroitin sulfate(CS) is a commercial drug applied for preventing cardiovascular diseases in clinics, suggesting a potential application for functionalized coatings. Our previous work demonstrated that the CS conjugated onto the poly-dopamine(PDA)/hexanediamine(HD) co-deposited 316 L stainless steel(316 L SS) could endow the surface stronger multi-functions for cardiovascular implants. However, the natural CS has two subtypes, CS A and CS C,while it is still unclear which subtype makes more contribution to the surface modification of cardiovascular implants. Thus, the present study focus on comparing CS A and CS C via preparing functionalized coatings on the cardiovascular implants. Our data suggested PDA/HD-CS C coating possessed better blood compatibility and pro-endothelialization function through controlling the phenotype and distribution of macrophages, smooth muscle cells and endothelial cells in time sequence and space sequence.展开更多
基金the National Natural Science Foundation of China (U2004164)Top Doctor Program of Zhengzhou University (grant number 32210475)。
文摘Surface functionalization is generally accepted as one of the most useful methods for endowing better biocompatibility of the cardiovascular implants. Chondroitin sulfate(CS) is a commercial drug applied for preventing cardiovascular diseases in clinics, suggesting a potential application for functionalized coatings. Our previous work demonstrated that the CS conjugated onto the poly-dopamine(PDA)/hexanediamine(HD) co-deposited 316 L stainless steel(316 L SS) could endow the surface stronger multi-functions for cardiovascular implants. However, the natural CS has two subtypes, CS A and CS C,while it is still unclear which subtype makes more contribution to the surface modification of cardiovascular implants. Thus, the present study focus on comparing CS A and CS C via preparing functionalized coatings on the cardiovascular implants. Our data suggested PDA/HD-CS C coating possessed better blood compatibility and pro-endothelialization function through controlling the phenotype and distribution of macrophages, smooth muscle cells and endothelial cells in time sequence and space sequence.
