The movement of the floating connecting mechanism between a hydraulic support and scraper conveyor is space movement;thus,when the hydraulic support pushes the scraper conveyor,there is an error between the actual dis...The movement of the floating connecting mechanism between a hydraulic support and scraper conveyor is space movement;thus,when the hydraulic support pushes the scraper conveyor,there is an error between the actual distance of the scraper conveyor and the theoretical moving distance.As a result,the scraper conveyor cannot obtain the straightness requirement.Therefore,the movement law of the floating connecting mechanism between the hydraulic support and scraper conveyor is analyzed and programmed into the Unity3D to realize accurate pushing of the scraper conveyor via hydraulic support.The Coal Seam?Equipment Joint Virtual Straightening System is established,and a straightening method based on the motion law of a floating connection is proposed as the default method of the system.In addition,a straightening simulation of the scraper conveyor was performed on a complex coal seam floor,the results demonstrate that the average straightening error of the scraper conveyor is within 2-8 mm,and is in direct proportion to the fluctuation of the coal seam floor in the strike of the seam with high accuracy,the straightness of scraper conveyor is more affected by the subsidence terrain during straightening than by the bulge terrain.And some conclusions are verified by experiment.Based on the verification of the relevant conclusions,a comparison and analysis of Longwall Automation Steering Committee(LASC)straightening technology and default straightening method in the simulation system shows that the straightness accuracy of LASC straightening technology under complex floor conditions is slightly less than that of the default straightening method in the proposed system.展开更多
Objective:The objective is to investigate the effect of five‑animal frolics on anxiety and depression of hospitalized inpatients.Materials and Methods:Totally 50 inpatients from departments of Internal Medicine,Surger...Objective:The objective is to investigate the effect of five‑animal frolics on anxiety and depression of hospitalized inpatients.Materials and Methods:Totally 50 inpatients from departments of Internal Medicine,Surgery and General Medicine with hospital admission date between January 2019 and July 2020 were included.All patients exercise five‑animal frolics under the professional guidance of the nurse in charge.The Hospital Anxiety and Depression Scale(HADS)was used to assess the conditions of anxiety and depression of patients before and after taking five‑animal frolics exercise.Results:The overall score of anxiety patients was significantly lower after five‑animal frolics exercise than before[6.0(5.0,8.0)vs.10.0(8.0,12.0),Z=‑5.466,P<0.001];the overall depression score of patients was significantly lower after five‑animal frolics exercise than before[6.5(4.0,8.0)vs.10.0(8.0,14.0),Z=‑5.175,P<0.001].There were 26(52.0%)very effective cases after exercise,16(32.0%)effective cases,8(16.0%)invalid cases,and the effective rate was 84.0%Conclusion:Taking five‑animal frolics exercise can improve anxiety and depression of inpatients.展开更多
Mitophagy,essential for mitochondrial health,selectively degrades damaged mitochondria.It is intricately linked to the cGAS-STING pathway,which is crucial for innate immunity.This pathway responds to mitochondrial DNA...Mitophagy,essential for mitochondrial health,selectively degrades damaged mitochondria.It is intricately linked to the cGAS-STING pathway,which is crucial for innate immunity.This pathway responds to mitochondrial DNA and is associated with cellular stress response.Our review explores the molecular details and regulatory mechanisms of mitophagy and the cGAS-STING pathway.We critically evaluate the literature demonstrating how dysfunctional mitophagy leads to neuroinflammatory conditions,primarily through the accumulation of damaged mitochondria,which activates the cGAS-STING pathway.This activation prompts the production of pro-inflammatory cytokines,exacerbating neuroinflammation.This review emphasizes the interaction between mitophagy and the cGAS-STING pathways.Effective mitophagy may suppress the cGAS-STING pathway,offering protection against neuroinflammation.Conversely,impaired mitophagy may activate the cGAS-STING pathway,leading to chronic neuroinflammation.Additionally,we explored how this interaction influences neurodegenerative disorders,suggesting a common mechanism underlying these diseases.In conclusion,there is a need for additional targeted research to unravel the complexities of mitophagy-cGAS-STING interactions and their role in neurodegeneration.This review highlights potential therapies targeting these pathways,potentially leading to new treatments for neuroinflammatory and neurodegenerative conditions.This synthesis enhances our understanding of the cellular and molecular foundations of neuroinflammation and opens new therapeutic avenues for neurodegenerative disease research.展开更多
基金This research was supported by the Project funded by National Natural Science Foundation of China(Grant No.52004174)China Postdoctoral Science Foundation(No.2019M651081)+2 种基金the Key Research and Development Program of Shanxi(201903D121141)the Natural Science Foundation of Shanxi Province(201901D211022)the Scientific and Technological Innovation Programs of Higher Education Institutions in Shan Xi(No.2019L0305).
文摘The movement of the floating connecting mechanism between a hydraulic support and scraper conveyor is space movement;thus,when the hydraulic support pushes the scraper conveyor,there is an error between the actual distance of the scraper conveyor and the theoretical moving distance.As a result,the scraper conveyor cannot obtain the straightness requirement.Therefore,the movement law of the floating connecting mechanism between the hydraulic support and scraper conveyor is analyzed and programmed into the Unity3D to realize accurate pushing of the scraper conveyor via hydraulic support.The Coal Seam?Equipment Joint Virtual Straightening System is established,and a straightening method based on the motion law of a floating connection is proposed as the default method of the system.In addition,a straightening simulation of the scraper conveyor was performed on a complex coal seam floor,the results demonstrate that the average straightening error of the scraper conveyor is within 2-8 mm,and is in direct proportion to the fluctuation of the coal seam floor in the strike of the seam with high accuracy,the straightness of scraper conveyor is more affected by the subsidence terrain during straightening than by the bulge terrain.And some conclusions are verified by experiment.Based on the verification of the relevant conclusions,a comparison and analysis of Longwall Automation Steering Committee(LASC)straightening technology and default straightening method in the simulation system shows that the straightness accuracy of LASC straightening technology under complex floor conditions is slightly less than that of the default straightening method in the proposed system.
基金Changping District Health Science and Technology Development special funds(No.2018‑4‑08)Beijing Changping Nankou Hospital.
文摘Objective:The objective is to investigate the effect of five‑animal frolics on anxiety and depression of hospitalized inpatients.Materials and Methods:Totally 50 inpatients from departments of Internal Medicine,Surgery and General Medicine with hospital admission date between January 2019 and July 2020 were included.All patients exercise five‑animal frolics under the professional guidance of the nurse in charge.The Hospital Anxiety and Depression Scale(HADS)was used to assess the conditions of anxiety and depression of patients before and after taking five‑animal frolics exercise.Results:The overall score of anxiety patients was significantly lower after five‑animal frolics exercise than before[6.0(5.0,8.0)vs.10.0(8.0,12.0),Z=‑5.466,P<0.001];the overall depression score of patients was significantly lower after five‑animal frolics exercise than before[6.5(4.0,8.0)vs.10.0(8.0,14.0),Z=‑5.175,P<0.001].There were 26(52.0%)very effective cases after exercise,16(32.0%)effective cases,8(16.0%)invalid cases,and the effective rate was 84.0%Conclusion:Taking five‑animal frolics exercise can improve anxiety and depression of inpatients.
基金supported by Natural Science Foundation of China(No.81903829,China)Department of Science and Technology of Sichuan Province(Nos.2022YFS0620,2024YFHZ0361,and 22ZDYF3784,China)+3 种基金Macao Science and Technology Development Fund of Macao SAR(Nos.SKL-QRCM(MUST)-2020-2022 and MUST-SKL-2021-005,China)Southwest Medical University(Nos.2021ZKZD015,2021ZKZD018,and 2021ZKMS046,China)Central Government Funds of Guiding Local Scientific and Technological Development(No.23ZYZYTS0211,China)Luzhou Science and Technology Project,China(No.2022-SYF73,China).
文摘Mitophagy,essential for mitochondrial health,selectively degrades damaged mitochondria.It is intricately linked to the cGAS-STING pathway,which is crucial for innate immunity.This pathway responds to mitochondrial DNA and is associated with cellular stress response.Our review explores the molecular details and regulatory mechanisms of mitophagy and the cGAS-STING pathway.We critically evaluate the literature demonstrating how dysfunctional mitophagy leads to neuroinflammatory conditions,primarily through the accumulation of damaged mitochondria,which activates the cGAS-STING pathway.This activation prompts the production of pro-inflammatory cytokines,exacerbating neuroinflammation.This review emphasizes the interaction between mitophagy and the cGAS-STING pathways.Effective mitophagy may suppress the cGAS-STING pathway,offering protection against neuroinflammation.Conversely,impaired mitophagy may activate the cGAS-STING pathway,leading to chronic neuroinflammation.Additionally,we explored how this interaction influences neurodegenerative disorders,suggesting a common mechanism underlying these diseases.In conclusion,there is a need for additional targeted research to unravel the complexities of mitophagy-cGAS-STING interactions and their role in neurodegeneration.This review highlights potential therapies targeting these pathways,potentially leading to new treatments for neuroinflammatory and neurodegenerative conditions.This synthesis enhances our understanding of the cellular and molecular foundations of neuroinflammation and opens new therapeutic avenues for neurodegenerative disease research.
