The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with primates.In recent year...The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with primates.In recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain atlas.However,the limited availability of tree shrews globally remains a substantial challenge in the field.Additionally,determining the key questions best answered using tree shrews constitutes another difficulty.Tree shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative diseases.Despite these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical research.This review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this model.We emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew studies.The use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.展开更多
Our previous findings have demonstrated that autophagy regulation can alleviate the decline of learning and memory by eliminating deposition of extracellular beta-amyloid peptide （Aβ） in the brain after stroke, but...Our previous findings have demonstrated that autophagy regulation can alleviate the decline of learning and memory by eliminating deposition of extracellular beta-amyloid peptide （Aβ） in the brain after stroke, but the exact mechanism is unclear. It is presumed that the regulation of beta-site APP-deaving enzyme 1 （BACE1）, the rate-limiting enzyme in metabolism of Aβ, would be a key site. Neuro-2a/amyloid precursor protein 695 （APP695） cell models of cerebral isch- emia were established by oxygen-glucose deprivation to investigate the effects of Rapamycin （an autophagy inducer） or 3-methyladenine （an autophagy inhibitor） on the expression of BACE1. Either oxygen-glucose deprivation or Rapamycin down-regulated the expression of BACE1 while 3-methyladenine up-regulated BACE1 expression. These results confirm that oxygen-glucose deprivation down-regulates BACE1 expression in Neuro-2a/APP695 cells through the introduction of autophagy.展开更多
Objective:To investigate the effects of mirror neuron theory-based visual feedback therapy(VFT)on restoration of upper limb function of stroke patients and motor-related cortical function using functional magnetic res...Objective:To investigate the effects of mirror neuron theory-based visual feedback therapy(VFT)on restoration of upper limb function of stroke patients and motor-related cortical function using functional magnetic resonance imaging(fMRI).Methods:Hemiplegic stroke patients were randomly divided into two groups:a VFT group and a control(CTL)group.Sixteen patients in the VFT group received conventional rehabilitation(CR)and VFT for 8 weeks,while 15 patients in the CTL group received only CR.The Barthel Index(BI)was used to assess the activities of daily living at baseline and the 8th week of the recovery training period.The Fugl-Meyer assessment(FMA)scale,somatosensory evoked potential(SEP),and fMRI were used to evaluate the recovery effect of the training therapies.The latencies and amplitudes of N9 and N20 were measured.Before recovery training,fMRI was performed for all patients in the VFT and CTL groups.In addition,17 patients(9 in the VFT group and 8 in the CTL group)underwent fMRI for follow-up 2 months after treatment.Qualitative data were analyzed using the x2 test.The independent sample t-test was used to compare normally distributed data among different groups,the paired sample t-test was used to compare data between groups,and the non-parametric test was used to comparing data without normal distribution among groups.Results:There were no significant differences between the VFT and CTL group in all indexes.However,after 8 weeks of recovery training,these indexes were all significantly improved(P<0.05).As compared with the CTL group,the FMA scores,BI,and N9/N20 latencies and amplitudes of SEP in the VFT group were significantly improved(P<0.05).Two months after recovery training,fMRI showed that the degree of activation of the bilateral central anterior gyrus.parietal lobe,and auxiliary motor areas was significantly higher in the VFT group than the CTL group(P<0.05).Conclusions:VFT based on mirror neuron theory is an effective approach to improve upper extremity motor function and daily activity performance of stroke patients.The therapeutic mechanism promotes motor relearning by activating the mirror neuron system and motor cortex.SEP amplitudes increased only for patients who participated in visual feedback.VFT promotes sensory-motor plasticity and behavioral changes in both the motor and sensory domains.展开更多
With the successful demonstration of terahertz(THz)high-speed wireless data transmission,the THz frequencies are now becoming a worth candidate for post-5G wireless communications.On the other hand,to bring THz commun...With the successful demonstration of terahertz(THz)high-speed wireless data transmission,the THz frequencies are now becoming a worth candidate for post-5G wireless communications.On the other hand,to bring THz communications a step closer to real scenario application,solving high data rate realtime transmission is also an important issue.This paper describes a 220-GHz solid-state dual-carrier wireless link whose maximum transmission real-time data rates are 20.8 Gbps(10.4 Gbps per channel).By aggregating two carrier signals in the THz band,the contradiction between high real-time data rate communication and low sampling rate analog-to-digital(ADC)and digital-to-analog converter(DAC)is alleviated.The transmitting and receiving front-ends consist of 220-GHz diplexers,220-GHz sub-harmonic mixers based on anti-parallel Schottky barrier diodes,G-band low-noise amplifiers(LNA),WR-4.3 band high-gain Cassegrain antennas,high data rates dual-DAC and-ADC baseband platform and other components.The low-density parity-check(LDPC)encoding is also realized to improve the bit error rate(BER)of the received signal.Modulated signals are centered at 214.4 GHz and 220.6 GHz with-11.9 dBm and-13.4 dBm output power for channel 1 and 2,respectively.This link is demonstrated to achieve 20.8-Gbps real-time data transmission using 16-QAM modulation over a distance of 1030 m.The measured signal to noise ratio(SNR)is 17.3 dB and 16.5 dB,the corresponding BER is 8.6e-7 and 3.8e-7,respectively.Furthermore,4K video transmission is also carried out which is clear and free of stutter.The successful transmission of aggregated channels in this wireless link shows the great potential of THz communication for future wireless high-rate real-time data transmission applications.展开更多
Adsorptive recovery of valuable components from industrial wastewater is highly desirable for avoiding resource wastage but remains a challenge.Herein,we develop an efficient continuous adsorption process for recoveri...Adsorptive recovery of valuable components from industrial wastewater is highly desirable for avoiding resource wastage but remains a challenge.Herein,we develop an efficient continuous adsorption process for recovering aromatic compounds in wastewater from styrene monomer and propylene oxide coproduction(SMPO)plant.Based on our insight into the potential of bio-based porous materials for adsorption application,starch-graft-polystyrene(SPS)and aryl-modifiedβ-cyclodextrin(ACD)were prepared,and novel hypercrosslinked porous polymers combined SPS with ACD(HSPS-ACDs)were synthesized through external crosslinking approach.In a binary-component system,the best-performing one HSPS-ACD(H)with high ACD content and large specific surface area possessed superior capacities for the representative aromatic compounds,acetophenone(AP,2.81 mmol·g^(-1))and 1-phenylethanol(1-PE,1.35 mmol·g^(-1))compared with the previously reported materials.Further,the adsorption properties of aromatic compounds on HSPS-ACD(H)were investigated in batch mode.For practical application,continuous adsorption experiments were conducted in a HSPS-ACD(H)-packed fixed bed,where the target aromatic components in wastewater were effectively retained and further released by elution.Besides showing the reversible adsorption and efficient enrichment effect,the HSPS-ACD(H)-packed fixed bed also maintained great stability in multiple cycles.Moreover,quantum chemical calculations were performed to elucidate the potential mechanism of adsorption of AP and 1-PE onto HSPS-ACD(H).展开更多
BACKGROUND： Previously, time data were analyzed by using constituent ratio or relative ratio; however, circular statistical analysis could exactly provide average peak phase of diseases. OBJECTIVE： To investigate th...BACKGROUND： Previously, time data were analyzed by using constituent ratio or relative ratio; however, circular statistical analysis could exactly provide average peak phase of diseases. OBJECTIVE： To investigate the correlation of solar term peak with onset and death of acute ischemic stroke. DESIGN： Retrospective case analysis. SETTINGS： Emergency Department of Foshan Municipal Hospital of Traditional Chinese Medicine; Department of Science and Education, the Second People＇s Hospital of Foshan. PARTICIPANTS： A total of 1 597 patients with acute ischemic stroke were selected from Emergency Room, Department of Neurology, Foshan Municipal Hospital of Traditional Chinese Medicine from 1994 to 2002. There were 875 males and 722 females, and their ages ranged from 33 to 97 years. All cases met the diagnostic criteria of acute cerebral infarction modified by the Second National Cerebrovascular Disease Academic Meeting; meanwhile, they were diagnosed with CT/MRI test. Patients and their relatives provided the confirmed consent. METHODS： Solar term of onset was retrospectively analyzed in 1 597 patients with acute ischemic stroke; among them, solar term of death in 90 cases were analyzed by using circular statistical analysis to calculate peak phase of onset and death of acute ischemic stroke and investigate the correlation of solar term with onset and death of acute ischemic stroke. MAIN OUTCOME MEASURES： Onset and death time of patients with acute ischemic stroke. RESULTS： Solar term of onset in 1 597 patients, especially solar term of death in 90 patients, was not concentrated （P 〉 0.05）, and specific peak phase was not found out. Acute ischemic stroke low attacked from vernal equinox to summer begins, but death caused by acute ischemic stroke high attacked from grain buds to autumn begins. CONCLUSION： Patients with acute ischemic stroke do not have specific solar term peak of onset and death.展开更多
AIM: To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs.METHODS: We have analyzed the immunological, liver function and cirrhosis markers in a cohort ...AIM: To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs.METHODS: We have analyzed the immunological, liver function and cirrhosis markers in a cohort of hemophiliacs co-infected with human immunodeficiency virus (HIV) and hepatitis viruses.RESULTS: There was no difference in immunological markers among co-infected patients and patients infected with HIV only and those co-infected with one or more hepatitis virus. Although liver function and cirrhosis markers remained within a normal range, there was a worsening trend in all patients co-infected with hepatitis virus C (HCV), which was further exacerbated in the presence of additional infection with hepatitis virus B (HBV).CONCLUSION: Co-infection with HIV, HBV and HCV leads to worsening of hyaluronic acid and liver function markers. Increases in serum hyaluronic acid may be suggestive of a predisposition to liver diseases.展开更多
The effect of a tilted-dipole three-dimensional corotating interaction region(CIR)on the transport and acceleration of solar energetic particles(SEPs)is studied.In this work,we discussed how the particle intensity lon...The effect of a tilted-dipole three-dimensional corotating interaction region(CIR)on the transport and acceleration of solar energetic particles(SEPs)is studied.In this work,we discussed how the particle intensity longitudinal and radial dependence might be influenced by the background structures.Moreover,we investigate how the spectral index distribution is modulated by the CIR structure We use the focused transport equation(FTE)to describe the propagation and acceleration of SEPs in a tilt-dipole 3D CIR,generated by the high-resolution 3D magnetohydrodynamic(MHD)model.The forward stochastic differential method is used to solve the FTE.The protons with theE~(-4.4)spectrum from 0.5 to 15 MeV are injected uniformly at the heliographic equator of 0.15 AU.Physical quantities are extracted along each interplanetary magnetic field(IMF)line to show the results.In the tilted-dipole CIR background,if injected from the solar equator at the inner boundary,particles in the slow flow are transported to higher latitudes due to the extension of the IMF lines to higher latitudes.The longitudinal patterns of the particles are dominated by the density of IMF lines.The focusing effect modulates the longitudinal variation of the particle intensity and gives rise to new longitudinal intensity peaks.The adiabatic effect largely increases the intensity fluctuation along the longitude.The structure of the solar wind can also lead to the difference of the indexαin the empirical functionI_(max)=kR~(-α),describing the radial variation of peak intensity according to our simulation.Under the influence of the CIR structure,the indexαvaries from 1.9 to 3.4 at 0.3-1.0 AU.The variation of the solar wind speed should be considered when estimating the radial dependence of the SEP peak intensity.The spectra indices rise near the CIR boundaries and drop near the stream interface(SI).The adiabatic effect makes the spatial variability of the spectral index larger.The spectral index could be similar at different radial distances in the CIR structure.展开更多
Developing high performance anode catalysts for oxygen evolution reaction (OER) and hydrazine oxidation reaction (HzOR) at large current density is an efficient pathway to produce hydrogen. Herein, we synthesize a FeW...Developing high performance anode catalysts for oxygen evolution reaction (OER) and hydrazine oxidation reaction (HzOR) at large current density is an efficient pathway to produce hydrogen. Herein, we synthesize a FeWO_(4)-WO_(3) heterostructure catalyst growing on nickel foam (FeWO_(4)-WO_(3)/NF) by a combination of hydrothermal and calcination method. It shows good catalytic activity with ultralow potentials for OER (ζ_(10) = 1.43 V, ζ_(1.000) = 1.56 V) and HzOR (ζ_(10) = −0.034 V, ζ_(1.000) = 0.164 V). Moreover, there is little performance degradation after being tested for _(10)0 h at 1,000 (OER) and _(10)0 (HzOR) mA·cm−2, indicating good stability. The superior performance could be attributed to the wolframite structure and heterostructure: The former provides a high electrical conductivity to ensure the electronic transfer capability, and the later induces interfacial electron redistribution to enhance the intrinsic activity and stability. The work offers a brand-new way to prepare good performance catalysts for OER and HzOR, especially at large current density.展开更多
Background: Although technically regarded as a simple procedure, titanium mesh cranioplasty could lead to various surgical complications, including postoperative implant exposure. However, there is little data availab...Background: Although technically regarded as a simple procedure, titanium mesh cranioplasty could lead to various surgical complications, including postoperative implant exposure. However, there is little data available on the occurrence and risk factors of this complication in the pediatric population. Cases presentation: Two pediatric male patients, one 12-year-old and one 7-year-old, had decompressive craniectomy after traumatic brain injuries and subsequent cranioplasty with titanium mesh. However, both patients had skin defects developed gradually at the scalp adjacent to the surgical incisions, 11 and 7 months after cranioplasty, respectively. Implants removal surgeries were then delivered and, during the operation, some bone debris were found just beneath the skin defects in both patients. Because microbiological culture results of the exudations were negative, in addition to the long interval between cranioplasty and developments of skin defects, surgical infections might not be major causes of the observed titanium implants exposures. On the other hand, local osteogenesis and impaired scalp blood supply might contribute to their occurrence. Conclusions: Efforts should be made to achieve complete clearance of bone debris and protect scalp blood supply during the initial decompressive craniectomy in order to minimize the risks of subsequent titanium mesh exposures.展开更多
Background: The orbit is susceptible to traumatic injuries, and surgical management of transorbital penetrating injury with foreign body retention is challenging due to the associated risks of nervous and vascular inj...Background: The orbit is susceptible to traumatic injuries, and surgical management of transorbital penetrating injury with foreign body retention is challenging due to the associated risks of nervous and vascular injury. Application of multiple imaging modalities is helpful for the preoperative surgical planning, and technical advances in percutaneous endoscopy would render the surgical approach even less invasive. Case presentation: We present a 60-year-old female patient with a transorbital penetrating injury (TPI) caused by a bamboo stick in her right eye. The bamboo stick was initially pulled out at the emergency room but, 1 month later, massive bleeding from her nose and mouth occurred. CT and CTA revealed a foreign body in the right orbito-cranial region and a traumatic aneurysm at the right internal carotid artery. Endovascular embolization was first delivered to treat the aneurysm, and the remains of the bamboo stick were completely removed with a percutaneous endoscope. The patient was discharged 1 week later. Conclusions: A careful preoperative examination by multiple imaging modalities, e.g., CT, MRI, and DSA are essential for the correct diagnosis and surgical planning for the patient with a TPI. We minimised the associated risks of vascular and nervous injuries during foreign body removal by sequential application of the endovascular intervention and percutaneous endoscopic technique.展开更多
基金supported by the STI2030-Major Projects(2021ZD0200900 to Y.G.Y.)"Light of West China" Program of the Chinese Academy of Sciences(xbzg-zdsys-202302 to Y.G.Y.)
文摘The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with primates.In recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain atlas.However,the limited availability of tree shrews globally remains a substantial challenge in the field.Additionally,determining the key questions best answered using tree shrews constitutes another difficulty.Tree shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative diseases.Despite these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical research.This review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this model.We emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew studies.The use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.
基金supported by the National Natural Science Foundation of China,No.31171014,31371065a grant from Shanghai Municipal Health Bureau,China,No.20134125a grant from Shanghai Pudong District Health Bureau of China,No.PDZz2013-10
文摘Our previous findings have demonstrated that autophagy regulation can alleviate the decline of learning and memory by eliminating deposition of extracellular beta-amyloid peptide （Aβ） in the brain after stroke, but the exact mechanism is unclear. It is presumed that the regulation of beta-site APP-deaving enzyme 1 （BACE1）, the rate-limiting enzyme in metabolism of Aβ, would be a key site. Neuro-2a/amyloid precursor protein 695 （APP695） cell models of cerebral isch- emia were established by oxygen-glucose deprivation to investigate the effects of Rapamycin （an autophagy inducer） or 3-methyladenine （an autophagy inhibitor） on the expression of BACE1. Either oxygen-glucose deprivation or Rapamycin down-regulated the expression of BACE1 while 3-methyladenine up-regulated BACE1 expression. These results confirm that oxygen-glucose deprivation down-regulates BACE1 expression in Neuro-2a/APP695 cells through the introduction of autophagy.
基金This study was supported in part by grants from Zhejiang province medical and health technology achievement Funding project(2018ZH044)Zhejiang province medical and health science and technology project.(2020KY317)+1 种基金Zhejiang province natural science foundation(LQ19H170001)2019-2021 period key discipline construction plan funded project of traditional Chinese medicine in Jiaxing city(2019 XK-A07).
文摘Objective:To investigate the effects of mirror neuron theory-based visual feedback therapy(VFT)on restoration of upper limb function of stroke patients and motor-related cortical function using functional magnetic resonance imaging(fMRI).Methods:Hemiplegic stroke patients were randomly divided into two groups:a VFT group and a control(CTL)group.Sixteen patients in the VFT group received conventional rehabilitation(CR)and VFT for 8 weeks,while 15 patients in the CTL group received only CR.The Barthel Index(BI)was used to assess the activities of daily living at baseline and the 8th week of the recovery training period.The Fugl-Meyer assessment(FMA)scale,somatosensory evoked potential(SEP),and fMRI were used to evaluate the recovery effect of the training therapies.The latencies and amplitudes of N9 and N20 were measured.Before recovery training,fMRI was performed for all patients in the VFT and CTL groups.In addition,17 patients(9 in the VFT group and 8 in the CTL group)underwent fMRI for follow-up 2 months after treatment.Qualitative data were analyzed using the x2 test.The independent sample t-test was used to compare normally distributed data among different groups,the paired sample t-test was used to compare data between groups,and the non-parametric test was used to comparing data without normal distribution among groups.Results:There were no significant differences between the VFT and CTL group in all indexes.However,after 8 weeks of recovery training,these indexes were all significantly improved(P<0.05).As compared with the CTL group,the FMA scores,BI,and N9/N20 latencies and amplitudes of SEP in the VFT group were significantly improved(P<0.05).Two months after recovery training,fMRI showed that the degree of activation of the bilateral central anterior gyrus.parietal lobe,and auxiliary motor areas was significantly higher in the VFT group than the CTL group(P<0.05).Conclusions:VFT based on mirror neuron theory is an effective approach to improve upper extremity motor function and daily activity performance of stroke patients.The therapeutic mechanism promotes motor relearning by activating the mirror neuron system and motor cortex.SEP amplitudes increased only for patients who participated in visual feedback.VFT promotes sensory-motor plasticity and behavioral changes in both the motor and sensory domains.
基金the National Natural Science Foundation of China(NSFC)under Grant 91738102,Grant 61771116,and Grant 62022022。
文摘With the successful demonstration of terahertz(THz)high-speed wireless data transmission,the THz frequencies are now becoming a worth candidate for post-5G wireless communications.On the other hand,to bring THz communications a step closer to real scenario application,solving high data rate realtime transmission is also an important issue.This paper describes a 220-GHz solid-state dual-carrier wireless link whose maximum transmission real-time data rates are 20.8 Gbps(10.4 Gbps per channel).By aggregating two carrier signals in the THz band,the contradiction between high real-time data rate communication and low sampling rate analog-to-digital(ADC)and digital-to-analog converter(DAC)is alleviated.The transmitting and receiving front-ends consist of 220-GHz diplexers,220-GHz sub-harmonic mixers based on anti-parallel Schottky barrier diodes,G-band low-noise amplifiers(LNA),WR-4.3 band high-gain Cassegrain antennas,high data rates dual-DAC and-ADC baseband platform and other components.The low-density parity-check(LDPC)encoding is also realized to improve the bit error rate(BER)of the received signal.Modulated signals are centered at 214.4 GHz and 220.6 GHz with-11.9 dBm and-13.4 dBm output power for channel 1 and 2,respectively.This link is demonstrated to achieve 20.8-Gbps real-time data transmission using 16-QAM modulation over a distance of 1030 m.The measured signal to noise ratio(SNR)is 17.3 dB and 16.5 dB,the corresponding BER is 8.6e-7 and 3.8e-7,respectively.Furthermore,4K video transmission is also carried out which is clear and free of stutter.The successful transmission of aggregated channels in this wireless link shows the great potential of THz communication for future wireless high-rate real-time data transmission applications.
基金supported by National Natural Science Foundation of China(21868002 and 21961160741)the Natural Science Foundation of Guangxi Province(2018GXNSFAA281206,2020GXNSFGA297001,2020GXNSFAA297044)+2 种基金Dean Project of Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology(2021Z010)Specific research project of Guangxi for research bases and talents(AD18126005)special funding for‘Guangxi Bagui Scholars’,Guangxi scholarship fund for the middle-aged backbone teachers。
文摘Adsorptive recovery of valuable components from industrial wastewater is highly desirable for avoiding resource wastage but remains a challenge.Herein,we develop an efficient continuous adsorption process for recovering aromatic compounds in wastewater from styrene monomer and propylene oxide coproduction(SMPO)plant.Based on our insight into the potential of bio-based porous materials for adsorption application,starch-graft-polystyrene(SPS)and aryl-modifiedβ-cyclodextrin(ACD)were prepared,and novel hypercrosslinked porous polymers combined SPS with ACD(HSPS-ACDs)were synthesized through external crosslinking approach.In a binary-component system,the best-performing one HSPS-ACD(H)with high ACD content and large specific surface area possessed superior capacities for the representative aromatic compounds,acetophenone(AP,2.81 mmol·g^(-1))and 1-phenylethanol(1-PE,1.35 mmol·g^(-1))compared with the previously reported materials.Further,the adsorption properties of aromatic compounds on HSPS-ACD(H)were investigated in batch mode.For practical application,continuous adsorption experiments were conducted in a HSPS-ACD(H)-packed fixed bed,where the target aromatic components in wastewater were effectively retained and further released by elution.Besides showing the reversible adsorption and efficient enrichment effect,the HSPS-ACD(H)-packed fixed bed also maintained great stability in multiple cycles.Moreover,quantum chemical calculations were performed to elucidate the potential mechanism of adsorption of AP and 1-PE onto HSPS-ACD(H).
基金the grants from Guangdong Province Administration of Traditional Chinese Medicine, No.401007
文摘BACKGROUND： Previously, time data were analyzed by using constituent ratio or relative ratio; however, circular statistical analysis could exactly provide average peak phase of diseases. OBJECTIVE： To investigate the correlation of solar term peak with onset and death of acute ischemic stroke. DESIGN： Retrospective case analysis. SETTINGS： Emergency Department of Foshan Municipal Hospital of Traditional Chinese Medicine; Department of Science and Education, the Second People＇s Hospital of Foshan. PARTICIPANTS： A total of 1 597 patients with acute ischemic stroke were selected from Emergency Room, Department of Neurology, Foshan Municipal Hospital of Traditional Chinese Medicine from 1994 to 2002. There were 875 males and 722 females, and their ages ranged from 33 to 97 years. All cases met the diagnostic criteria of acute cerebral infarction modified by the Second National Cerebrovascular Disease Academic Meeting; meanwhile, they were diagnosed with CT/MRI test. Patients and their relatives provided the confirmed consent. METHODS： Solar term of onset was retrospectively analyzed in 1 597 patients with acute ischemic stroke; among them, solar term of death in 90 cases were analyzed by using circular statistical analysis to calculate peak phase of onset and death of acute ischemic stroke and investigate the correlation of solar term with onset and death of acute ischemic stroke. MAIN OUTCOME MEASURES： Onset and death time of patients with acute ischemic stroke. RESULTS： Solar term of onset in 1 597 patients, especially solar term of death in 90 patients, was not concentrated （P 〉 0.05）, and specific peak phase was not found out. Acute ischemic stroke low attacked from vernal equinox to summer begins, but death caused by acute ischemic stroke high attacked from grain buds to autumn begins. CONCLUSION： Patients with acute ischemic stroke do not have specific solar term peak of onset and death.
基金Supported by the Shanghai Public Health Center Research Fund
文摘AIM: To study the effect of hepatitis virus infection on cirrhosis and liver function markers in HIV-infected hemophiliacs.METHODS: We have analyzed the immunological, liver function and cirrhosis markers in a cohort of hemophiliacs co-infected with human immunodeficiency virus (HIV) and hepatitis viruses.RESULTS: There was no difference in immunological markers among co-infected patients and patients infected with HIV only and those co-infected with one or more hepatitis virus. Although liver function and cirrhosis markers remained within a normal range, there was a worsening trend in all patients co-infected with hepatitis virus C (HCV), which was further exacerbated in the presence of additional infection with hepatitis virus B (HBV).CONCLUSION: Co-infection with HIV, HBV and HCV leads to worsening of hyaluronic acid and liver function markers. Increases in serum hyaluronic acid may be suggestive of a predisposition to liver diseases.
基金jointly supported by the National Natural Science Foundation of China(42330210 and 41974202)the National Key R&D Program of China(grant Nos.2022YFF0503800 and2021YFA0718600)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB 41000000)the Specialized Research Fund for State Key Laboratories。
文摘The effect of a tilted-dipole three-dimensional corotating interaction region(CIR)on the transport and acceleration of solar energetic particles(SEPs)is studied.In this work,we discussed how the particle intensity longitudinal and radial dependence might be influenced by the background structures.Moreover,we investigate how the spectral index distribution is modulated by the CIR structure We use the focused transport equation(FTE)to describe the propagation and acceleration of SEPs in a tilt-dipole 3D CIR,generated by the high-resolution 3D magnetohydrodynamic(MHD)model.The forward stochastic differential method is used to solve the FTE.The protons with theE~(-4.4)spectrum from 0.5 to 15 MeV are injected uniformly at the heliographic equator of 0.15 AU.Physical quantities are extracted along each interplanetary magnetic field(IMF)line to show the results.In the tilted-dipole CIR background,if injected from the solar equator at the inner boundary,particles in the slow flow are transported to higher latitudes due to the extension of the IMF lines to higher latitudes.The longitudinal patterns of the particles are dominated by the density of IMF lines.The focusing effect modulates the longitudinal variation of the particle intensity and gives rise to new longitudinal intensity peaks.The adiabatic effect largely increases the intensity fluctuation along the longitude.The structure of the solar wind can also lead to the difference of the indexαin the empirical functionI_(max)=kR~(-α),describing the radial variation of peak intensity according to our simulation.Under the influence of the CIR structure,the indexαvaries from 1.9 to 3.4 at 0.3-1.0 AU.The variation of the solar wind speed should be considered when estimating the radial dependence of the SEP peak intensity.The spectra indices rise near the CIR boundaries and drop near the stream interface(SI).The adiabatic effect makes the spatial variability of the spectral index larger.The spectral index could be similar at different radial distances in the CIR structure.
基金This work is supported by the National Natural Science Foundation of China(No.21872040)the Hundred Talents Program of Guangxi Universities,the Excellent Scholars and Innovation Team of Guangxi Universities,Guangxi Major Projects of Science and Technology(No.GXMPSTAA17202032),Guangxi Ba-Gui Scholars Program.
文摘Developing high performance anode catalysts for oxygen evolution reaction (OER) and hydrazine oxidation reaction (HzOR) at large current density is an efficient pathway to produce hydrogen. Herein, we synthesize a FeWO_(4)-WO_(3) heterostructure catalyst growing on nickel foam (FeWO_(4)-WO_(3)/NF) by a combination of hydrothermal and calcination method. It shows good catalytic activity with ultralow potentials for OER (ζ_(10) = 1.43 V, ζ_(1.000) = 1.56 V) and HzOR (ζ_(10) = −0.034 V, ζ_(1.000) = 0.164 V). Moreover, there is little performance degradation after being tested for _(10)0 h at 1,000 (OER) and _(10)0 (HzOR) mA·cm−2, indicating good stability. The superior performance could be attributed to the wolframite structure and heterostructure: The former provides a high electrical conductivity to ensure the electronic transfer capability, and the later induces interfacial electron redistribution to enhance the intrinsic activity and stability. The work offers a brand-new way to prepare good performance catalysts for OER and HzOR, especially at large current density.
文摘Background: Although technically regarded as a simple procedure, titanium mesh cranioplasty could lead to various surgical complications, including postoperative implant exposure. However, there is little data available on the occurrence and risk factors of this complication in the pediatric population. Cases presentation: Two pediatric male patients, one 12-year-old and one 7-year-old, had decompressive craniectomy after traumatic brain injuries and subsequent cranioplasty with titanium mesh. However, both patients had skin defects developed gradually at the scalp adjacent to the surgical incisions, 11 and 7 months after cranioplasty, respectively. Implants removal surgeries were then delivered and, during the operation, some bone debris were found just beneath the skin defects in both patients. Because microbiological culture results of the exudations were negative, in addition to the long interval between cranioplasty and developments of skin defects, surgical infections might not be major causes of the observed titanium implants exposures. On the other hand, local osteogenesis and impaired scalp blood supply might contribute to their occurrence. Conclusions: Efforts should be made to achieve complete clearance of bone debris and protect scalp blood supply during the initial decompressive craniectomy in order to minimize the risks of subsequent titanium mesh exposures.
基金This study was supported by Science and Technology Department of Zhejiang Province(Grant 2007C33042)%Zhejiang Provincial Natural Science Foundation(Grant Y14H090041)
文摘Background: The orbit is susceptible to traumatic injuries, and surgical management of transorbital penetrating injury with foreign body retention is challenging due to the associated risks of nervous and vascular injury. Application of multiple imaging modalities is helpful for the preoperative surgical planning, and technical advances in percutaneous endoscopy would render the surgical approach even less invasive. Case presentation: We present a 60-year-old female patient with a transorbital penetrating injury (TPI) caused by a bamboo stick in her right eye. The bamboo stick was initially pulled out at the emergency room but, 1 month later, massive bleeding from her nose and mouth occurred. CT and CTA revealed a foreign body in the right orbito-cranial region and a traumatic aneurysm at the right internal carotid artery. Endovascular embolization was first delivered to treat the aneurysm, and the remains of the bamboo stick were completely removed with a percutaneous endoscope. The patient was discharged 1 week later. Conclusions: A careful preoperative examination by multiple imaging modalities, e.g., CT, MRI, and DSA are essential for the correct diagnosis and surgical planning for the patient with a TPI. We minimised the associated risks of vascular and nervous injuries during foreign body removal by sequential application of the endovascular intervention and percutaneous endoscopic technique.
