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Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel
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作者 Takumi Endo Naoto Kamiya +8 位作者 Hiroyoshi Suzuki Ryo Oka fang-ching lee Takanobu Utsumi Masashi Yano Shuichi Kamijima Koji Kawamura Takashi Imamoto Tomohiko Ichikawa 《World Journal of Clinical Urology》 2014年第2期139-143,共5页
AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC) patients treated with docetaxel.METHODS: Thirty-three patients were enr... AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer(CRPC) patients treated with docetaxel.METHODS: Thirty-three patients were enrolled in this study. Serum levels of carboxyterminal cross-linked telopeptide of type 1 collagen generated by metalloproteinases(1CTP) and alkaline phosphatase(ALP) were measured at the start of docetaxel chemotherapy. We examined the relationship between clinicopathological features and serum levels of 1CTP and ALP levels in CRPC patients treated with docetaxel.RESULTS: For the total patient group, the mean ± standard deviation(SD) values for docetaxel chemotherapy dose, dose intensity, dosage interval, and num-ber of cycles were 59.3 ± 10.6 mg/m2, 13.9 ± 5.2 mg/m2 per week, 4.7 ± 1.2 wk, and 11.2 ± 7.4, respectively. Fourteen patients died from prostate cancer. Patients were divided into two groups according to mean + SD of serum 1CTP(8.2 ng/m L) and ALP(538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels(P < 0.05).CONCLUSION: Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel. 展开更多
关键词 PROSTATE cancer DOCETAXEL chemotherapy Carboxy-terminal PYRIDINOLINE CROSS-LINKED telopeptide parts of type-1 collagen Alkaline PHOSPHATASE PROGNOSTIC factor
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