Diagnostic and prognostic role of long noncoding RNA MALAT1 in breast cancer:a meta-analysis

Background:This systematic analysis aspired to investigate the diagnostic and prognostic role of metastasis associated lung adenocarcinoma transcript 1(MALAT1)in breast cancer.Methods:We conducted a search in PubMed,EMBASE,MEDLINE,Web of Science,CNKI,Wanfang and VIP databases to identify eligible articles,and combined the effect sizes using Stata 15.0 and Meta-Disc 1.4.Results:19 articles were identifed in our study,including 9 diagnostic articles and 11 prognostic articles.For the diagnostic meta-analysis,the pooled specificity,sensitivity,diagnostic odds ratio,area under the curve of MALAT1 in confirming breast cancer were 0.77(95%confidence interval(CI):0.68-0.84),0.81(95%CI:0.71-0.88),14.09(95%CI:6.34-31.31)and 0.85(95%CI:0.82-0.88),separately.The subgroup analysis demonstrated that the diagnostic effect of MALAT1 in triple negative breast cancer was higher than in breast cancer.For the survival outcomes meta-analysis,patients with over-expression of MALAT1 had poor overall survival,recurrence free survival,metastasis-free survival,disease specific survival and disease free survival.Conclusion:MALAT1 may serve as a promising biomarker for diagnosis and prognosis for confirming breast cancer.

Discussion on Maxing Ganshi Decoction in the Treatment of COVID-19 Based on Triple Energizer Transmission Theory

COVID-19 is caused by novel coronavirus(2019-nCoV),which has the characteristics of strong infectivity,rapid onset and rapid spread.It is popular in China and other parts of the world,and there are no special drugs at present.This disease belongs to the category of plague in traditional Chinese medicine.Combined with the theory of triple energizer transmission in Yang Lishan's"Identification of Warm Disease",the confirmed case in our hospital was analyzed,and it was found that pathogenic qi entered from nose and mouth,injected into middle energizer,and then distributed in upper and lower energizer.The pathogenic qi is mainly diffused in the middle and upper energizer.Modified Maxing Ganshi decoction has a good effect.

Clinical efficacy of integrated Chinese and western medicine in the treatment of the corona virus disease 2019(COVID-19):A meta-analysis

Objective:To evaluate the clinical efficacy of integrated Chinese and western medicine(ICWM)in the treatment of COVID-19.Methods:Literature retrieval was performed in PubMed,Cochrane Library,EMBASE,Web of science,CNKI,VIP and Wanfang database from inception to November 1,2020.The data extraction and quality assessment were completed by two independent reviewers.Meta-analysis was performed using Review Manager 5.3.Results:30 clinical trials were included with 3379 participants.The meta-analysis showed that there were significant differences in the total effective rate(RR=1.24,95%CI[1.15,1.35];P<0.01),the conversion rate from mild or moderate to severe(RR=0.32,95%CI[0.24,0.44];P<0.01),the mortality(RR=0.52,95%CI[0.30,0.93];P<0.05),the disappearance time of fever(MD=-1.60,95%CI[-1.99,-1.21];P<0.01)and cough(MD=-1.43,95%CI[-1.96,-0.90];P<0.01)and fatigue(MD=-1.44,95%CI[-2.33,-0.55];P<0.01),the rate of CT improvement(RR=1.29,95%CI[1.13,1.47];P<0.01)and the rate of adverse reactions(RR=0.52,95%CI[0.31,0.87];P<0.05)between ICWM and western medicine(WM)alone.While there were no differences between two groups in the cure rate(RR=1.22,95%CI[0.98,1.52];P>0.05)and the disappearance rate of fatigue(RR=1.18,95%CI[0.97,1.45];P>0.05).Conclusion:Meta-analysis results indicated that ICWM in the treatment of COVID-19 can improve clinical efficacy and safety.However,high-quality,large-sample,multi-center RCTs are required to confirm the efficacy of traditional Chinese medicine intervention COVID-19.

Research progress of traditional Chinese medicine in the treatment of breast cancer based on “Binding of Phlegm and Stasis”

Breast cancer is a common malignancy in female,which seriously endangers women’s health.Chinese medicine believed that the incidence of breast cancer is related to“Stagnation of Liver-Qi”and“Phlegm,Disharmony of Thoroughfare and Conception Vessels”,“Stagnation of Qi and Blood Stasis”,constitution and other characteristics.Modern research believed that phlegm is related to abnormal energy metabolism of tumor cells,and stasis is the pathological change of tumor angiogenesis.How to combine tumor angiogenesis and energy replacement abnormality with the theory of“Binding of Phlegm and Stasis”has become a new direction of traditional Chinese medicine anti-tumor research.The drugs of“Activating Blood Circulation”and“Removing Blood Stasis”,“Resolving Phlegm”and“Dispersing Constipation”have a wide range of pharmacological effects and definite curative effect.They have the functions of anti-inflammatory,anti-tumor,anti-pathogenic microorganism and improving the immune ability of the body.In this paper,the effects and mechanisms of phlegm-reducing and stasis dispersing active ingredients and compound preparations in regulating angiogenesis and energy metabolism of breast cancer were reviewed,and the differences in efficacy,targets and pathways of Phlegm-Reducing and Stasis Dispersing drugs were summarized,so as to provide some reference for the research and development of traditional Chinese medicine for breast cancer.