BACKGROUND Diabetic retinopathy(DR)is a diabetic complication that can severely affect the patients’vision,eventually leading to blindness.DR is the most important manifestation of diabetic micro-vasculopathy and is ...BACKGROUND Diabetic retinopathy(DR)is a diabetic complication that can severely affect the patients’vision,eventually leading to blindness.DR is the most important manifestation of diabetic micro-vasculopathy and is mainly related to the course of diabetes and the degree of blood glucose control,while the age of diabetes onset,sex,and type of diabetes have little influence on it.AIM To explore the changes in blood oxygen saturation and oxidative stress indices of retinal vessels in patients with DR.METHODS In total,94 patients(94 eyes)with DR(DR group)diagnosed at Jianyang people’s Hospital between March 2019 and June 2020,and 100 volunteers(100 eyes)(control group)without eye diseases,were included in this study.Arterial and venous blood oxygen saturation,retinal arteriovenous vessel diameter,and serum oxidative stress indicators in the two groups were compared.Based on the stage of the disease,the DR group was divided into the simple DR and proliferative DR groups for stratified analysis.RESULTS The oxygen saturation of the retinal vessels in the DR group was significantly higher than that in the control group(P<0.05).The retinal vessel diameters between the DR and control groups were not significantly different.The serum malondialdehyde(MDA)and 8-hydroxydehydroguanosine(8-OHdG)levels in the DR group were significantly higher than those in the control group(P<0.05).The serum superoxide dismutase(SOD)and reduced glutathione(GSH)levels in the DR group were significantly lower than those in the control group (P < 0.05). The oxygensaturation of the retinal vessels in the patients with proliferative DR was significantly higher thanthat in the patients with simple DR (P < 0.05). The retinal vessel diameter in patients with proliferativeDR was not significantly different from that of patients with simple DR (P > 0.05). SerumMDA and 8-OHdG levels in patients with proliferative DR were significantly higher than those inpatients with simple DR (P < 0.05). Serum SOD and GSH levels in patients with proliferative DRwere significantly lower than those in patients with simple DR (P < 0.05).CONCLUSIONIncreased blood oxygen saturation of retinal arteries and veins and increased oxidative stressdamage in patients with DR may be associated with decreased retinal capillary permeability andarterial oxygen dispersion, possibly reflecting the patient’s condition.展开更多
文摘BACKGROUND Diabetic retinopathy(DR)is a diabetic complication that can severely affect the patients’vision,eventually leading to blindness.DR is the most important manifestation of diabetic micro-vasculopathy and is mainly related to the course of diabetes and the degree of blood glucose control,while the age of diabetes onset,sex,and type of diabetes have little influence on it.AIM To explore the changes in blood oxygen saturation and oxidative stress indices of retinal vessels in patients with DR.METHODS In total,94 patients(94 eyes)with DR(DR group)diagnosed at Jianyang people’s Hospital between March 2019 and June 2020,and 100 volunteers(100 eyes)(control group)without eye diseases,were included in this study.Arterial and venous blood oxygen saturation,retinal arteriovenous vessel diameter,and serum oxidative stress indicators in the two groups were compared.Based on the stage of the disease,the DR group was divided into the simple DR and proliferative DR groups for stratified analysis.RESULTS The oxygen saturation of the retinal vessels in the DR group was significantly higher than that in the control group(P<0.05).The retinal vessel diameters between the DR and control groups were not significantly different.The serum malondialdehyde(MDA)and 8-hydroxydehydroguanosine(8-OHdG)levels in the DR group were significantly higher than those in the control group(P<0.05).The serum superoxide dismutase(SOD)and reduced glutathione(GSH)levels in the DR group were significantly lower than those in the control group (P < 0.05). The oxygensaturation of the retinal vessels in the patients with proliferative DR was significantly higher thanthat in the patients with simple DR (P < 0.05). The retinal vessel diameter in patients with proliferativeDR was not significantly different from that of patients with simple DR (P > 0.05). SerumMDA and 8-OHdG levels in patients with proliferative DR were significantly higher than those inpatients with simple DR (P < 0.05). Serum SOD and GSH levels in patients with proliferative DRwere significantly lower than those in patients with simple DR (P < 0.05).CONCLUSIONIncreased blood oxygen saturation of retinal arteries and veins and increased oxidative stressdamage in patients with DR may be associated with decreased retinal capillary permeability andarterial oxygen dispersion, possibly reflecting the patient’s condition.
