Piezoelectric Pump Used in Bionic Underwater Propulsion Unit

A new piezoelectric pump can pump liquid either forward or backward and adjust the flow rate. Thus an object can be driven forward or backward at different speeds. The driver of the pump, a circular piezoelectric plate, is modelled by Finite Element Method （FEM） in ANSYS and its performance is simulated and analyzed. The pump gives the best performance when the driving signals of the inlet and outlet valves have a bigger duty cycle and the plate has a higher voltage applied.

Study on the molecular mechanism of Gegen Qinlian decoction in the treatment of influenza based on network pharmacology

Objective:The study shows that Gegen Qinlian decoction(GGQL)is feasible in the treatment of influenza.It is explained from traditional Chinese medicine theory and modern pharmacology,and the formula is tested in vitro.The results show that Gegen Qinlian decoction has a good inhibitory effect on influenza virus.Methods:Search TCMSP database to get the components and targets of GGQL,and construct the compound target network.Then search OMIM database and Disgenet database to obtain influenza genes,and the common genes were obtained by VennDiagram.STRING database was used to construct gene function association network.Finally,David database was used to analyze GO enrichment and pathway enrichment.Results:146 ingredients and 128 targets were obtained,588 genes were obtained.46 common genes were obtained by VennDiagram,and import the common genes into the STRING database and construct the gene function association network,then the network information data was imported into Cytoscape software for topology analysis.Finally,13 enriched GO clusters and 7 enriched pathway clusters were obtained by David database,and construct the targets-GO-pathway network.Conclusion:Network pharmacology of GGQL reveal that the target and the pathway of the drug was closely related to influenza,and the results of this study have been verified with published experimental studies,which shows that GGQL has not only theoretical basis for the treatment of influenza,but also in vitro experiments support this conclusion.

A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis

Background:Hematopoietic stem cells(HSCs)have the ability to differentiate into all subsets of blood cells and self-renew.Large tumor suppressor 1(LATS1)and large tumor suppressor 2(LATS2)kinases are essential for cell cycle regulation,organism fitness,genome integrity,and cancer prevention.Here,we investigated whether Lats1 and Lats2 are critical for the maintenance of the selfrenewal and quiescence capacities of HSCs in mice.Methods:Quantitative reverse transcription-polymerase chain reaction was used to determine the expression levels of Lats1 and Lats2 in subsets of progenitor cells and mature bone marrow cells.A clustered regularly interspaced short palindromic repeats system was used to generate Lats1 or Lats2 knockout mice.Complete blood cell counts were used to compare the absolute number of white blood cells,lymphocytes,monocytes,neutrophils,and platelets between Lats1 or Lats2 heterozygotes and littermates.Flow cytometry was used to assess the size of hematopoietic progenitor cells(HPCs)and HSC pools in Lats1 or Lats2 heterozygotes and littermates.The comparison between the two groups was analyzed using Student’s t test.Results:Lats1 and Lats2 were widely expressed in hematopoietic cells with higher expression levels in primitive hematopoietic cells than in mature cells.Lats1 or Lats2 knockout mice were generated,with the homozygotes showing embryonic lethality.The size of the HPC and HSC pools in Lats1(HPC:wild-type[WT]vs.heterozygote,220,426.77±54,384.796 vs.221,149.4±42,688.29,P=0.988;HSC:WT vs.heterozygote,2498.932±347.856 vs.3249.763±370.412,P=0.105)or Lats2(HPC:WT vs.heterozygote,425,540.52±99,721.86 vs.467,127.8±89,574.48,P=0.527;HSC:WT vs.heterozygote,4760.545±1518.01 vs.5327.437±873.297,P=0.502)heterozygotes were not impaired.Moreover,the depletion of Lats1 or Lats2 did not affect the overall survival of the heterozygotes(Lats1:P=0.654;Lats2:P=0.152).Conclusion:These results indicate that a single allele of Lats1 or Lats2 may be sufficient for normal hematopoiesis.

Pulse-potential electrochemistry to boost real-life application of pseudocapacitive dual-doped polypyrrole

Polypyrrole(PPy)is a very promising pseudocapacitive electrode material for supercapacitors.However,the poor electrochemical performances and cycling stability caused by volumetric change and counterion drain severely limited its practical application and commercialization.Herein,we present a pulsepotential polymerization strategy for uniformly depositing a dual-doped PPy with ordered and shorter molecular structure by balancing the concentration polarization.Such a strategy ensures more homogeneous stress distribution of PPy during ultralong cycling tests and improves the cycle stability.Moreover,the pulse-potential polymerized PPy with dual anion doping behavior induces enhanced protonation level and improved electrical conductivity,which boosting the charge transfer kinetics.Therefore,the as-synthesized PPy exhibits a remarkable capacitance performance(7250 mF/cm^(2)@3 mA/cm^(2)),outstanding rate capability(3073 mF/cm^(2)@200 mA/cm^(2))and a long cycle life.The assembled symmetric and asymmetric supercapacitors(ASC)exhibit good energy densities(0.8 mWh/cm^(2) for ASC and 0.5 mWh/cm^(2) for symmetric supercapacitor),and excellent durability with zero capacitive loss after 35,000 cycles.In addition,we have fabricated small pouch devices,which can effectively operate a variety of electronic products(including the high-voltage 5 V smartphone,and tablet)and well withstand the external extreme tests during operation,demonstrating the quantitative investigation of the real-life application of aqueous supercapacitors.