The separation of water isotopologues has been a“century-old”challenge,also known as“the Holy Grail”in separation science.Heavy water(D2O)is a stable non-radioactive water isotopologue that plays a critical role i...The separation of water isotopologues has been a“century-old”challenge,also known as“the Holy Grail”in separation science.Heavy water(D2O)is a stable non-radioactive water isotopologue that plays a critical role in scientific research,military,nuclear energy,and medical fields.Heavy water was first reported in 1931 when H.C.Urey discovered D2 and D2O,for which he was awarded the Nobel Prize in Chemistry in 1934.Then in 1933,G.N.Lewis et al.obtained 0.5μL of heavy water at a concentration of around 65.7%when electrolyzing 10 liters of water.In 1935,the world's first heavy water plant was built in Norway,producing 2 tons of heavy water by electrolysis,but the separation factor was merely 1.05,which was extremely energy-consuming.In 1943,the first heavy water plant employing the distillation method was built in the United States.展开更多
In the present study,it is found that the prepared alumina ceramics has better mineralization ability in a newly revised simulated body fluid.With the extension of mineralization time,the amount of hydroxyapatite(HA)c...In the present study,it is found that the prepared alumina ceramics has better mineralization ability in a newly revised simulated body fluid.With the extension of mineralization time,the amount of hydroxyapatite(HA)crystals deposited on the surface of alumina ceramics also increased gradually.The results of cell biological experiments of alumina ceramics with hydroxyapatite surface layer demonstrate that the mineralized materials have better biological activity and osteogenesis properties in vitro.In the meanwhile,the ALP activity and expression of osteogenesis-related genes(OPN,ALP,Col-I,and OCN)of mouse bone marrow stromal stem cells on the samples were significantly promoted by increasing the formation of HA on the surface of alumina ceramics.Our research concluded that alumina ceramics with HA phase on surface had great potential to be developed as a sort of bioactive material in the bone repair field.展开更多
基金supported by the National Natural Science Foundation of China(No.52170119)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2021044).
文摘The separation of water isotopologues has been a“century-old”challenge,also known as“the Holy Grail”in separation science.Heavy water(D2O)is a stable non-radioactive water isotopologue that plays a critical role in scientific research,military,nuclear energy,and medical fields.Heavy water was first reported in 1931 when H.C.Urey discovered D2 and D2O,for which he was awarded the Nobel Prize in Chemistry in 1934.Then in 1933,G.N.Lewis et al.obtained 0.5μL of heavy water at a concentration of around 65.7%when electrolyzing 10 liters of water.In 1935,the world's first heavy water plant was built in Norway,producing 2 tons of heavy water by electrolysis,but the separation factor was merely 1.05,which was extremely energy-consuming.In 1943,the first heavy water plant employing the distillation method was built in the United States.
基金National Natural Science Foundation of China(Grant no.52172280)National Key R&D Program of China(Grant no.2016YFB0700803).
文摘In the present study,it is found that the prepared alumina ceramics has better mineralization ability in a newly revised simulated body fluid.With the extension of mineralization time,the amount of hydroxyapatite(HA)crystals deposited on the surface of alumina ceramics also increased gradually.The results of cell biological experiments of alumina ceramics with hydroxyapatite surface layer demonstrate that the mineralized materials have better biological activity and osteogenesis properties in vitro.In the meanwhile,the ALP activity and expression of osteogenesis-related genes(OPN,ALP,Col-I,and OCN)of mouse bone marrow stromal stem cells on the samples were significantly promoted by increasing the formation of HA on the surface of alumina ceramics.Our research concluded that alumina ceramics with HA phase on surface had great potential to be developed as a sort of bioactive material in the bone repair field.
