In this paper, He’s variational iterative method has been applied to give exact solution of the Euler Lagrange equation which arises from the variational problems with moving boundaries and isoperimetric problems. In...In this paper, He’s variational iterative method has been applied to give exact solution of the Euler Lagrange equation which arises from the variational problems with moving boundaries and isoperimetric problems. In this method, general Lagrange multipliers are introduced to construct correction functional for the variational problems. The initial approximations can be freely chosen with possible unknown constant, which can be determined by imposing the boundary conditions. Illustrative examples have been presented to demonstrate the efficiency and applicability of the variational iterative method.展开更多
In this paper, Bezier surface form is used to find the approximate solution of delay differential equations (DDE’s). By using a recurrence relation and the traditional least square minimization method, the best contr...In this paper, Bezier surface form is used to find the approximate solution of delay differential equations (DDE’s). By using a recurrence relation and the traditional least square minimization method, the best control points of residual function can be found where those control points determine the approximate solution of DDE. Some examples are given to show efficiency of the proposed method.展开更多
In this paper, Homotopy perturbation method is used to find the approximate solution of the optimal control of linear systems. In this method the initial approximations are freely chosen, and a Homotopy is constructed...In this paper, Homotopy perturbation method is used to find the approximate solution of the optimal control of linear systems. In this method the initial approximations are freely chosen, and a Homotopy is constructed with an embedding parameter , which is considered as a “small parameter”. Some examples are given in order to find the approximate solution and verify the efficiency of the proposed method.展开更多
Cancer immunotherapy aims at enhancing immune system to defend against the tumor. However, it is associated with injecting small doses of tumor-bearing molecules or even using drugs. The problem is that how to schedul...Cancer immunotherapy aims at enhancing immune system to defend against the tumor. However, it is associated with injecting small doses of tumor-bearing molecules or even using drugs. The problem is that how to schedule these injections effectively and/or how to apply drugs in a way to decrease toxic side effects of drugs such that the tumor growth to be stopped or at least to be limited. Here, the theory of optimal control has been applied to find the optimal schedule of injections of an immunotherapeutic agent against cancer. The numerical method employed works for any dynamic linear system and has almost precise solution. In this work, it was tested for a well known model of the tumor immune system interaction.展开更多
文摘In this paper, He’s variational iterative method has been applied to give exact solution of the Euler Lagrange equation which arises from the variational problems with moving boundaries and isoperimetric problems. In this method, general Lagrange multipliers are introduced to construct correction functional for the variational problems. The initial approximations can be freely chosen with possible unknown constant, which can be determined by imposing the boundary conditions. Illustrative examples have been presented to demonstrate the efficiency and applicability of the variational iterative method.
文摘In this paper, Bezier surface form is used to find the approximate solution of delay differential equations (DDE’s). By using a recurrence relation and the traditional least square minimization method, the best control points of residual function can be found where those control points determine the approximate solution of DDE. Some examples are given to show efficiency of the proposed method.
文摘In this paper, Homotopy perturbation method is used to find the approximate solution of the optimal control of linear systems. In this method the initial approximations are freely chosen, and a Homotopy is constructed with an embedding parameter , which is considered as a “small parameter”. Some examples are given in order to find the approximate solution and verify the efficiency of the proposed method.
文摘Cancer immunotherapy aims at enhancing immune system to defend against the tumor. However, it is associated with injecting small doses of tumor-bearing molecules or even using drugs. The problem is that how to schedule these injections effectively and/or how to apply drugs in a way to decrease toxic side effects of drugs such that the tumor growth to be stopped or at least to be limited. Here, the theory of optimal control has been applied to find the optimal schedule of injections of an immunotherapeutic agent against cancer. The numerical method employed works for any dynamic linear system and has almost precise solution. In this work, it was tested for a well known model of the tumor immune system interaction.
