Comparison among Ocular Response Analyzer,Corvis ST and Goldmann applanation tonometry in healthy children

AIM： To explore the relationship between different parameters of Ocular Response Analyzer（ORA） and Corvis ST（CST） in a sample of healthy Iranian school-aged children and the relationship between parameters of these 2 instruments against intraocular pressure（IOP）, measured by the Goldmann applanation tonometer（GAT-IOP）, age and gender, and find possible correlation between ORA and CST with GAT.METHODS： This cross-sectional study included 90 healthy children. A general interview and complete eye examination were performed. Following successful GATIOP measurement, ORA and CST were conducted. The CST parameters were A 1/2 length（A1 L, A2 L）, A 1/2 velocity（A1 V, A2 V）, highest concavity deformation amplitude（HCDA）, radius of curvature（Ro C）, peak distance（PD）, central corneal thickness（CCT） and IOP. The ORA parameters were corneal hysteresis（CH）, corneal resistance factor（CRF）, Goldmann-correlated IOP（IOP-G） and corneal compensated IOP（IOP-CC）. Extracted data was analyzed using the Statistical Package for Social Science software.RESULTS： Totally 39 males with age of 9.08±1.60（6-12）y and 51 females with age of 8.96±1.55（6-13）y were included. Many CST parameters were significantly correlated with CH, CRF, IOP-G and IOP-CC. Some CST parameters had a significant correlation with GAT-IOP, including IOP-CST in both eyes and HCDA, A2 L, PD, and RoC in the left eye, but none with age, except A2 L in the right eye. The CRF measurement showed a significant correlation with GAT-IOP in both eyes and CH in the right eye, yet, none with age. Among all CST and ORA parameters, CCT-CST in both eyes and A1 L in right eye had a significant correlation with gender, although this was a negligible negative correlation. Comparison of mean IOP values by different devices showed a significantly highest IOP overestimation by CST and lowest by IOP-CC compared with GAT. Also, IOP-G versus IOP-CST significantly had the lowest IOP overestimation among others. Overall, either low positive correlation or negligible correlation was found between IOP measurements by 3 instruments.CONCLUSION： The study finds the highest IOP overestimation by CST and lowest by IOP-CC compared with GAT. Overall, either low positive correlation or negligible correlation is found between IOP measurements by the 3 instruments.

COVID-19 and angiotensin-converting enzyme inhibitors from plant origin

We read with great interest the recently published review paper concerning angiotensin-converting enzyme(ACE)inhibitors from plants entitled“Angiotensin-Converting Enzyme Inhibitors from Plants:A Review of Their Diversity,Modes of Action,Prospects,and Concerns in the Management of Diabetes-Centric Complications”[1].