Background:Jaundea pinnata(JP),is a new plant native to North Africa,East Africa,Southern Nigeria,and Guinea.It is traditionally used as an anti-rheumatic,anti-inflammatory,antibacterial and antidiabetic herb,thus mak...Background:Jaundea pinnata(JP),is a new plant native to North Africa,East Africa,Southern Nigeria,and Guinea.It is traditionally used as an anti-rheumatic,anti-inflammatory,antibacterial and antidiabetic herb,thus making it a potential source for modern antidiabetic medications.Objective:This investigation aimed to assess the toxicological profile and the antidiabetic potentials of the methanol extract of the Jaundea pinnata(JP)leaf in mice and rats.Methods:Preliminary phytochemical screening of JP leaf was conducted using standard procedures.The plant extract’s acute and sub-chronic toxicity was evaluated using a modified OECD recommendation.In normal and streptozotocin-induced diabetic rats,its anti-diabetic action was tested over 28 days at doses of 100 mg/kg,200 mg/kg,and 400 mg/kg,with glibenclamide(10 mg/kg)and distilled water serving as the positive and negative controls,respectively.Relevant organs’histopathological analysis was also assessed.Results:According to the preliminary phytochemical analysis of the leaf extract,JP contains flavonoids,saponins,alkaloids,tannins,terpenoids,deoxy-sugars,and anthraquinones.The extract demonstrated an LD50 of above 2000 mg/kg in mice.On days 14,21,and 28 in streptozotocin-induced diabetic rats,the extract showed a dosedependent antidiabetic effect;nevertheless,the activity of the extract at 400 mg/kg on day 28 was barely comparable to that of glibenclamide(10 mg/kg).At 250 mg/kg,500 mg/kg,and 1500 mg/kg,respectively,the extract was appreciably non-toxic to the liver and kidney,while inducing a significant change in haematological indicators.Conclusion:The study found that JP presented antihyperglycemic properties and was relatively safe at normal dosages(<2000 mg/kg).展开更多
文摘Background:Jaundea pinnata(JP),is a new plant native to North Africa,East Africa,Southern Nigeria,and Guinea.It is traditionally used as an anti-rheumatic,anti-inflammatory,antibacterial and antidiabetic herb,thus making it a potential source for modern antidiabetic medications.Objective:This investigation aimed to assess the toxicological profile and the antidiabetic potentials of the methanol extract of the Jaundea pinnata(JP)leaf in mice and rats.Methods:Preliminary phytochemical screening of JP leaf was conducted using standard procedures.The plant extract’s acute and sub-chronic toxicity was evaluated using a modified OECD recommendation.In normal and streptozotocin-induced diabetic rats,its anti-diabetic action was tested over 28 days at doses of 100 mg/kg,200 mg/kg,and 400 mg/kg,with glibenclamide(10 mg/kg)and distilled water serving as the positive and negative controls,respectively.Relevant organs’histopathological analysis was also assessed.Results:According to the preliminary phytochemical analysis of the leaf extract,JP contains flavonoids,saponins,alkaloids,tannins,terpenoids,deoxy-sugars,and anthraquinones.The extract demonstrated an LD50 of above 2000 mg/kg in mice.On days 14,21,and 28 in streptozotocin-induced diabetic rats,the extract showed a dosedependent antidiabetic effect;nevertheless,the activity of the extract at 400 mg/kg on day 28 was barely comparable to that of glibenclamide(10 mg/kg).At 250 mg/kg,500 mg/kg,and 1500 mg/kg,respectively,the extract was appreciably non-toxic to the liver and kidney,while inducing a significant change in haematological indicators.Conclusion:The study found that JP presented antihyperglycemic properties and was relatively safe at normal dosages(<2000 mg/kg).
