Gain-of-function somatic mutations of SET binding protein 1(SETBP1)result in the accumulation of SETBP protein and are detected in 17%of secondary acute myeloid leukemia(AML)patients.1 In fact,high expression of SETBP...Gain-of-function somatic mutations of SET binding protein 1(SETBP1)result in the accumulation of SETBP protein and are detected in 17%of secondary acute myeloid leukemia(AML)patients.1 In fact,high expression of SETBP1 also drives adverse outcomes in human AML.However,the roles of SETBP1 during developmental hematopoiesis and AML progression are still not fully understood.Here we first sought to investigate the functions of SETBP1 in developmental hematopoiesis.展开更多
Aims Since 2000,the environmental flow controls project has been implemented in the lower Heihe River Basin,a typical arid inland river basin in northwest China,to restore the deteriorated ecological environment in th...Aims Since 2000,the environmental flow controls project has been implemented in the lower Heihe River Basin,a typical arid inland river basin in northwest China,to restore the deteriorated ecological environment in this region.The aim of this study was to explore the impacts of groundwater fluctuations on vegetation dynamics.Our results can be used as a reference for water resources planning and management to maintain proper environmental flows in arid areas.Methods The location(by Global Positioning System)and depth of the monitoring wells,as well as groundwater table depth and salinity were measured in situ at each site from July to August 2009.Based on the measurements of the groundwater table depth and salinity following the implementation of environmental flow controls project(EFCP)in the lower Heihe River Basin,the groundwater fluctuations during the period from 2001 to 2009 were analyzed.Descriptive statistics and Pearson’s correlation were used to analyze the relationship between vegetation changes and groundwater table fluctuations.Additionally,the spatial distributions of the groundwater table depth and salinity were interpolated using the simple kriging method.Trend analysis was applied to the time series of integrated Moderate Resolution Imaging Spectroradiometer normalized difference vegetation index data to identify interannual vegetation dynamics.The relationship between vegetation status and groundwater environment was investigated at different spatial scales by analyzing and comparing the time series and trends.Important Findings(i)The groundwater table and salinity increased significantly in most of the study area with spatial heterogeneity.On average,the groundwater table rose;0.5 and 1.5 m in the upper and lower Ejina Basin,respectively,and the groundwater salinity increased across the study area by 0–4%.(ii)A notable correlation between the vegetation status and the groundwater table was revealed when the groundwater table depth fluctuated between 1.8 and 3.5 m,whereas the vegetation did not show an obvious response to groundwater table changes when the groundwater table depth was more than 5–6 m.(iii)Vegetation restoration mainly occurred in riparian areas within 500–1000 m of from natural rivers,where the groundwater table depth varied from 2 to 4 m,and salinity was<5%,whereas vegetation degradation appeared at some locations where groundwater environment had deteriorated.展开更多
基金supported by grants from the National Natural Science Foundation of China (No.32000569)the Basic and Applied Basic Research Foundation of Guangdong Province,China (No.2019A1515110281).
文摘Gain-of-function somatic mutations of SET binding protein 1(SETBP1)result in the accumulation of SETBP protein and are detected in 17%of secondary acute myeloid leukemia(AML)patients.1 In fact,high expression of SETBP1 also drives adverse outcomes in human AML.However,the roles of SETBP1 during developmental hematopoiesis and AML progression are still not fully understood.Here we first sought to investigate the functions of SETBP1 in developmental hematopoiesis.
基金National Basic Research Program of China(973 Program)(No.2009CB421305)47th China Postdoctoral Science Foundation(No.20100470534)+1 种基金National Natural Science Foundation of China(No.40701050,40901024 and 91025023)and Hundred Talents Program of the Chinese Academy of Sciences。
文摘Aims Since 2000,the environmental flow controls project has been implemented in the lower Heihe River Basin,a typical arid inland river basin in northwest China,to restore the deteriorated ecological environment in this region.The aim of this study was to explore the impacts of groundwater fluctuations on vegetation dynamics.Our results can be used as a reference for water resources planning and management to maintain proper environmental flows in arid areas.Methods The location(by Global Positioning System)and depth of the monitoring wells,as well as groundwater table depth and salinity were measured in situ at each site from July to August 2009.Based on the measurements of the groundwater table depth and salinity following the implementation of environmental flow controls project(EFCP)in the lower Heihe River Basin,the groundwater fluctuations during the period from 2001 to 2009 were analyzed.Descriptive statistics and Pearson’s correlation were used to analyze the relationship between vegetation changes and groundwater table fluctuations.Additionally,the spatial distributions of the groundwater table depth and salinity were interpolated using the simple kriging method.Trend analysis was applied to the time series of integrated Moderate Resolution Imaging Spectroradiometer normalized difference vegetation index data to identify interannual vegetation dynamics.The relationship between vegetation status and groundwater environment was investigated at different spatial scales by analyzing and comparing the time series and trends.Important Findings(i)The groundwater table and salinity increased significantly in most of the study area with spatial heterogeneity.On average,the groundwater table rose;0.5 and 1.5 m in the upper and lower Ejina Basin,respectively,and the groundwater salinity increased across the study area by 0–4%.(ii)A notable correlation between the vegetation status and the groundwater table was revealed when the groundwater table depth fluctuated between 1.8 and 3.5 m,whereas the vegetation did not show an obvious response to groundwater table changes when the groundwater table depth was more than 5–6 m.(iii)Vegetation restoration mainly occurred in riparian areas within 500–1000 m of from natural rivers,where the groundwater table depth varied from 2 to 4 m,and salinity was<5%,whereas vegetation degradation appeared at some locations where groundwater environment had deteriorated.
