Idiopathic mesenteric phlebosclerosis missed by a radiologist at initial diagnosis: A case report

BACKGROUND Idiopathic mesenteric phlebosclerosis(IMP)is a rare type of ischemic colitis characterized by thickening of the wall of the right hemicolon and calcification,sclerosis,and fibrosis of mesenteric veins.The diagnosis of IMP is based on typical clinical features and imaging findings.We report a case of IMP that was initially missed by the radiologist.CASE SUMMARY A 77-year-old woman was admitted to the hospital due to chronic diarrhea for over 2 months.She had been consuming Chinese patent medicines(CPM)containing fructus gardeniae for more than 15 years.Colonoscopy revealed an edematous mucosa,bluish-purple discoloration,erosions,and ulcerations throughout the colorectal area.Abdominal computed tomography(CT)showed diffuse mural thickening of the entire colorectum,with tortuous thread-like calcifications in the right hemicolon,left hemicolon,and rectum.Most of the calcifications were located in the mesenteric vein.The diagnosis of IMP was established based on medical history,colonoscopy,CT findings,and histopathological examination.The patient was treated conservatively with papaverine and rifaximin,and CPM was stopped.Her diarrhea symptoms improved,indicating the effectiveness of the treatment.Over the next several years,she took opium alkaloids for an extended period and did not require hospitalization for the aforementioned gastrointestinal disorder.CONCLUSION IMP is a rare gastrointestinal disease affecting Asian populations,possibly related to long-term herbal medicine intake.Accurate imaging analysis is crucial for diagnosis,but insufficient understanding of the disease can lead to misdiagnosis or missed diagnosis.Treatment strategies should be personalized.

基于AHP-模糊评判的煤矿职业病危害综合评价

根据我国当前煤矿职业病危害现状及相关职业卫生技术规范,为了对当前我国煤矿职业危害现状进行科学的综合评价,选取煤尘、岩尘、氮氧化物、SO2、CO、高温、噪声作为评价因子,通过AHP(层次分析法)和模糊评判建立危害程度权重函数,得到主要危害因素为煤尘和岩尘。各评价地点综合危害程度由重到轻为锚喷支护点、岩巷掘进面、综采工作面、煤巷掘进面、机修车间和机电硐室。评判出井下不同地点职业病综合危害情况。

SLE伴视网膜病变的临床特征分析

目的:探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)伴视网膜病变的临床特征。方法:选取2015-02/2017-02在我院治疗的SLE患者121例,其中有视网膜病变30例(观察组),无视网膜病变91例(对照组),比较两组临床表现、实验室检查结果等。结果:观察组患者6例双眼视网膜病变,24例单眼视网膜病变;视网膜棉絮样渗出、视网膜血管阻塞和视网膜出血病变常见,分别占33%、25%和19%。观察组患者皮疹、皮肤血管炎和雷诺现象发生率分别为63%、47%和37%,均明显高于对照组(P<0.05);观察组和对照组患者黏膜溃疡、关节炎、神经精神症状和胸膜炎发生率比较,差异均无统计学意义(P>0.05)。观察组患者抗ds-DNA阳性率(63%)明显高于对照组(P<0.05);观察组和对照组患者蛋白尿≥3+、抗Sm抗体阳性、rRNP阳性和抗磷脂抗体阳性比例比较,差异均无统计学意义(P>0.05)。观察组患者SLEDAI评分为20.14(9,30)分,明显高于对照组(P<0.05)。观察组患者改良Ben Ezra评分为10.04±3.15分,与SLEDAI评分呈正相关(rs=0.706,P<0.05)。结论:SLE伴视网膜病变患者眼底主要表现为棉絮样斑、视网膜血管阻塞和视网膜出血;皮疹、皮肤血管炎、雷诺现象、抗ds-DNA抗体阳性在SLE伴视网膜病变患者中常见;改良Ben Ezra评分在评估SLE疾病活动及视网膜血管病变中有一定作用。

Effect of nitrogen fertilizer on distribution of starch granules in different regions of wheat endosperm

This study provided visual evidence of a nitrogen effect on starch granules(SGs) in wheat endosperm. Winter wheat(Titicum aestivum L.) cultivar Xumai 30 was cultured under no nitrogen(control) and 240 kg ha-1of nitrogen applied at the booting stage. The number, morphology, and size of Aand B-type SGs in subaleurone of dorsal endosperm(SDE), center of dorsal endosperm(CDE), modified aleurone(MA), subaleurone of ventral endosperm(SVE), and center of ventral endosperm(CVE) were observed under light and electron microscopes.(1) The distribution of SGs in SDE was similar to that in SVE, the distributions of SGs in CDE and CVE were similar, but the distribution of SGs in MA was different from those in the other four endosperm regions. The number of SGs in the five endosperm regions was in the order SDE > CDE > SVE > CVE > MA.(2) Nitrogen increased the number of Aand B-type SGs in SDE and SVE. Nitrogen also increased the number of B-type SGs but decreased the number of A-type SGs in CDE and CVE. Nitrogen decreased the numbers of A-type and B-type SGs in MA. The results suggest that increased N fertilizer application mainly increased the numbers of small SGs and decreased the numbers of large SGs, but that the results varied in different regions of the wheat endosperm.

Achievable complete remission of advanced non-small-cell lung cancer: Case report and review of the literature

Surgery is the first choice of treatment for patients with non-small-cell lung cancer(NSCLC), but few patients can be treated surgically because of either advanced disease or poor pulmonary function. Other therapies include radiotherapy and chemotherapy, as well as complementary and alternative therapies, usually with disappointing results. Bronchial artery infusion(BAI) is a manageable and effective method for treating advanced NSCLC. Outcome is good by BAI due to its repeatability and low toxicity. Icotinib hydrochloride is a newly developed and highly specific epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor and has been safely and efficiently used to treat advanced NSCLC. We herein report a 73-year-old patient with chronic cough, who was diagnosed with advanced NSCLC with the EGFR mutation of L858 R substitution in exon 21, and treated with the combination of oral icotinib and BAI chemotherapy as the first-line therapy, which resulted in a satisfactory clinical outcome. Complete remission of advanced NSCLC can be achieved using the combination of oral icotinib and BAI chemotherapy.

Morphological characteristics, anatomical structure, and gene expression: novel insights into gibberellin biosynthesis and perception during carrot growth and development

Gibberellins(GAs)are considered potentially important regulators of cell elongation and expansion in plants.Carrot undergoes significant alteration in organ size during its growth and development.However,the molecular mechanisms underlying gibberellin accumulation and perception during carrot growth and development remain unclear.In this study,five stages of carrot growth and development were investigated using morphological and anatomical structural techniques.Gibberellin levels in leaf,petiole,and taproot tissues were also investigated for all five stages.Gibberellin levels in the roots initially increased and then decreased,but these levels were lower than those in the petioles and leaves.Genes involved in gibberellin biosynthesis and signaling were identified from the carrotDB,and their expression was analyzed.All of the genes were evidently responsive to carrot growth and development,and some of them showed tissue-specific expression.The results suggested that gibberellin level may play a vital role in carrot elongation and expansion.The relative transcription levels of gibberellin pathway-related genes may be the main cause of the different bioactive GAs levels,thus exerting influences on gibberellin perception and signals.Carrot growth and development may be regulated by modification of the genes involved in gibberellin biosynthesis,catabolism,and perception.

Mechanical behaviours of sandstone containing intersecting fissures under uniaxial compression

Predicting rock cracking is important for assessing the stability of underground engineering.The effects of the intersecting angle a and the distribution orientation angleβof intersecting fissures on the uniaxial compressive strength and the failure characteristics of sandstone containing intersecting fissures are investigated through laboratory experiments and two-dimensional particle flow code(PFC2D).The relationship between the mechanical properties of sandstone and the intersecting angle a and the distribution orientation angleβis analysed.Crack initiation forms and the final failure modes are then categorised and determined via empirical methods.In addition,the cracking processes of intersecting fissures with different a andβvalues are discussed.The results show that variations in the peak stress,peak strain,average modulus,and crack initiation stress of sandstone containing intersecting fissures show a“moth”shape in the space of the a-β-mechanical parameters.Two crack initiation forms are identified:inner tip cracking(usually accompanied by one outer tip cracking)and only outer tips cracking.Two failure modes are observed:(1)the main fracture planes are created at the inner tip and one outer tip,and(2)the main fracture planes are formed at the two outer tips.Two main crack evolution processes of sandstone containing intersecting fissures under uniaxial compression are found.Approaches for quickly determining the crack initiation form and the failure mode are proposed.The combination of the determination equations for the crack initiation form and the failure mode can be used to predict the crack evolution.The approach for determining the crack evolution processes is hence proposed with acceptable precision.

Analysis of User's Weight in Microblog Network Based on User Influence and Active Degree

Based on user＇s in-degree distribution, traditional ranking algorithms of user＇s weight usually neglect the considerations of the differences among user＇s followers and the features of user＇s tweets. In order to analyze the factors which impact on user＇s weight, under the analysis of the data collected from SINA Microblog network, this paper discovers that user influence and active degrees are the dominant factors for this issue. The proposed algorithm evaluates user influence by user＇s follower number, the influence of user＇s followers and the reciprocity between users. User＇s active degree is modeled by user＇s participation and the quality of user＇s tweets. The models are tested by different data groups to confirm the parameters for the final calculation. Eventually, this paper compares the computational results with the user＇s ranking order given by the SINA official application. The performance of this algorithm presents a stronger stability on the fluctuant range of the value of user＇s weight.

旋转机器人手臂奇异位形分析

对旋转机器人的机械手臂进行奇异位形分析。首先,运用D-H参数方法构建与该机械手臂对应的坐标系图,并建立相应的运动学模型,进而求得其正运动方程;然后,根据机械臂正运动方程构造与之对应的雅可比矩阵,之后对机械臂进行分析,从而求出该机械手臂所有可能出现奇异状态的情形;最后,运用MATLAB ROBOT TOOLBOX对机械手臂的奇异情形进行仿真及验证。分析结果表明,主要存在3种奇异位形,以及3种奇异情形之间的组合情况,不仅预判出所有可能会发生奇异位形的情况,也验证了前期奇异位形求解结果的正确性,为后期机械臂运动路线规划,以及实现对奇异点的规避奠定了基础。

Cytological and molecular characteristics of delayed spike development in wheat under low temperature in early spring

Low temperature in early spring impairs wheat growth and grain yield.However,little is known about the cytological and molecular mechanisms underlying low temperature regulation of wheat spike development.Microstructure observation and transcriptome sequencing of wheat spikes under low temperature were conducted.Low temperature slowed spike development,reduced the yield-component parameters of wheat spikes at the harvest stage,delayed the formation of lateral spikelets and tissue development,and induced the early differentiation of terminal spikelets.Low temperature increased the content of abscisic acid and caused the upregulation of genes in the abscisic acid signaling pathway,including those encoding PP2 Cs,Sn RK2 s,and b ZIP transcription factors.Low temperature also induced the upregulation of 33 cold-responsive genes involved in wheat response to low-temperature stress and regulation of abscisic acid biosynthesis and metabolism of other substances.The wheat spike adapted to cold conditions by changing the expression levels of genes involved in spike morphogenesis,including the transcription-factor genes MADS6,ERF4,ERF78,WOX6,and NAC48.These findings suggest that low temperature in early spring delays wheat spike development by increasing abscisic acid content or affecting the expression of genes involved in morphogenesis.

PMU-WAMS research and application in Brazil

Wide area measurement system(WAMS), which is based on synchronization data from phasor measurement units(PMU) and EMS SCADA, is implemented to establish a system model that can handle certain functions such as realtime power system monitoring, oscillation mode analysis, accident analysis and decision-making assistance for emergency control. The Brazilian Interconnected Power System(BIPS) is a large system covering an extensive geographical region, which faces certain risks and challenges. It has several main transmission corridors associated with large power plants and interconnection between the northern and southeastern regions. Mismatch between the energy base and load pool also exists in Brazil as energy resources are not well-distributed; therefore, the use of large-capacity, long-distance transmission technique to transmit remote power is unescapable. On the other hand, there are many types of voltage levels and multiple entangled electromagnetic loops owing to historical reasons. Then, for insufficient power reservation and defective grid body in load pools, once the external power is cut, it's easy to raise a blackout. The infrastructure is old and the power system operates close to the upper limit. All these represent risks and challenges to BIPS. Through WAMS technology research method in this project, the electrical power system function of monitoring, analysis, and control improved from the static state to the dynamic state. WAMS enhances data integration and real-time analysis capabilities, and can provide dispatchers with high quality real-time dynamic information and decision-making support information, enhance monitoring of auxiliary services in the electricity market, enable operators to improve the accuracy of power network analysis, thereby increasing power grid monitoring and operation, and improve the transmission capacity and reliability of the power grid operation [1].

Use of three dimensional-printing in the management of floating aortic thrombus due to occult aortic dissection:A case report

BACKGROUND Floating thrombus within the thoracic aorta is a rare entity but may cause systemic embolism.The pathogenesis of floating aortic thrombi is not yet fully understood.No definitive guidelines are available for the management of floating aortic thrombus.CASE SUMMARY We report a 48-year-old patient,without a history of trauma and infection,who presented with sudden severe back pain.A floating thrombus within the aortic arch was found by computed tomography angiography(CTA).No evidence of coagulopathies was found.However,with the assistance of a three dimensionalprinted model,this floating thrombus was identified to be caused by occult aortic dissection(AD).Subsequently,an emergency thoracic endovascular repair was performed.The patient’s back pain was rapidly alleviated postoperatively.CTA at 1 year showed no filling defect in the stent-graft and aorta.CONCLUSION Occult AD is a potential factor causing floating aortic thrombi,endovascular stent-graft exclusion may be an optimal therapeutic choice with promising results.Moreover,the combination of CTA and three dimensional-printed models can contribute to the diagnosis and treatment of floating aortic thrombi due to occult AD.

Spatial distribution of Pb and its correlation at different grain positions among wheat varieties for specific end-uses

The relative content of Pb and its correlation were investigated in endosperm, aleurone layer and pericarp respectively among different wheat varieties for specific end-uses (WVFSE) using scanning electron microscope (SEM) equipped with the energy dispersive X-ray spectroscope (EDS). The results showed that Pb contents in grains at different positions followed the order of endosperm > pericarp > aleurone. The differences of Pb contents varied among the WVFSE, and wheat with strong gluten had a highest average content of Pb, while wheat with medium gluten had a lowest one. There were significant third order equation correlations between Pb content in endosperm and that in aleurone layer and that in pericarp, respectively. And good correlation coefficients were obtained. However, the correlation differed at different position among WVFSE, which indicated that Pb contents in endosperm, aleurone layer and pericarp were regulated by each other.

Effects of Organic Fertilizers Made from Distiller＇s Grains on the Growth and Development of Flue-cured Tobacco

Pot experiments were conducted to study the effects of different organic fertilizers made from distiller＇s grains on the physiological characteristics and growth of flue-cured tobacco. The results showed that the agronomic traits and biomass of flue-cured tobacco in the three treatments were higher than that of the control group,and the mixed application of different organic fertilizers made from distiller＇s grains and compound fertilizer could promote the growth and development of flue-cured tobacco significantly.

Comparison of nutrition education policies and programs for children in China and other selected developed countries

A double burden of overweight/obesity and malnutrition during childhood is a major concern in China.Dietary intakes in this critical period affect children’s physical and cognitive development,and also have health consequences in later life.Therefore,establishing healthy eating habits that will endure is crucial for children.Nutrition education is an effective way in improving nutrition knowledge and attitudes,and healthy eating behaviors.Diverse forms of nutrition improvement programs that targeting children,family,teachers,and school settings have been conducted in many developed countries.However,due to the differences of genetic background,household environment as well as dietary patterns between Chinese children and children from other countries,the existing nutrition education programs for children abroad might not be appropriate for children in China.Thus,nutrition education programs that consider Chinese nutrition-related policies and food supply as well as the local educational resources are required for Chinese children.This review summarized nutrition-related policies and legislations in China and developed countries.A series of evidence-based nutrition education programs that combined educational strategies and environmental supports conducted in the Southwest China Childhood Nutrition and Growth Study were presented.These programs can serve as example models for adopting nutrition interventions to improve nutrition and health status of children in different regions of China.

Mecanum轮参数化设计和运动学分析

全方位移动平台在拥挤的环境中运行时,由于轮子的非完整性约束,使用传统的或者滑动转向的普通轮式车辆虽然可以到达环境中的任何位置和方向,但可能需要更加复杂的操作以及环境的要求。为了在局部不平地面条件下应用Mecanum轮,总结出在实际装车环境下的几种不平地面条件,根据条件约束提出了Mecanum轮的结构设计,并针对Mecanum轮的辊子进行了参数化的设计和计算。为了提高Mecanum轮的性能,对结构进行了运动学分析。对辊子的参数化设计为其精密制造提供了理论依据。

Cautiously using natural medicine to treat liver problems

Natural medicine is a system of therapy that administrates natural agents and their derivatives to treat human diseases.This medicine has been used to treat many kinds of human diseases for thousands of years.The treatment protocols of natural medicine are integrative in nature,and are required to utilize the most appropriate therapies to address the needs of the individual patient.Because of the relative convenience,safety and efficacy,natural medicine is now increasing worldwide.Naturopathic doctors are licensed in many areas of the world and regulated partly by law in these areas,which is quite different from various other forms of complementary and alternative medicine.Liver diseases,such as hepatitis,liver cirrhosis and liver carcinoma,are serious health problems worldwide.Nearly half of the natural agents used in treatment of liver diseases today are natural products and their derivatives.Although natural medicine is beneficial and safe,physicians should pay close attention to the potential side-effects of the naturopathic agents,which lead to liver injury,interstitial pneumonia and acute respiratory failure.Therefore,when administrating naturopathic protocols to patients for the treatment of liver diseases,we should try our best to prevent and avoid as much as possible the negative impact of these medicines.This article highlights the current practice and recommended improvement of natural medicines in the treatment of liver diseases and gives some specific examples to emphasize the prevention and management of adverse reactions of the natural agents and suggests that natural medicine should be cautiously used to treat liver problems.

Investigation into Improvement for Anti-Rollover Propensity of SUV

Currently, many research from domestic and foreign on improving anti-rollover performance of vehicle mainly focus on the electronic control of auxiliary equip- ment, do not make full use of suspension layout to optimize anti-rollover performance of vehicle. This investigation into anti-rollover propensity improvement concentrates on the vehicle parameters greatly influencing on anti-rollover propensity of vehicle. A simulation based on fishhook procedure is used to perform design trials and evaluations aimed at ensuring an optimal balance between vehicle＇s design parameters and various engineering capacities, the anti-rollover propensity is optimized at the detailed design stage of a new SUV model. Firstly a four-DOF theoretical kinematic model is established, then a complete multi-body dynamics model built in ADAMS/car based on the whole vehicle parameters is correlated to the objective handing and stability test results of a mule car. Secondly, in fish- hook test simulations, the Design of Experiments method is used to quantify the effect of the vehicle parameters on the anti-rollover performance. By means of the simulation, the roll center height of front suspension should be more than 30 mm, that of rear suspension less than 150 mm, and the HCG less than 620 mm for the SUV. The ratio of front to rear suspension roll stiffness should be ranged from 1.4 to1.6 for the SUV. As a result, at the detailed design stage of product, the anti-rollover performance of vehicle can be improved by optimizing chassis and integrated vehicle parameters.

Malignant obstruction in the ileocecal region treated by selfexpandable stent placement under the fluoroscopic guidance: A case report

BACKGROUND Malignant tumors of the ileocecal region often cause intestinal obstruction.Emergency surgery is the main treatment for patients presenting with an obstruction.However,this procedure is associated with a high mortality rate and frequent complications.The placement of colon stents is commonly performed for obstructions in the distal colon and is a less invasive and safer procedure.However,obstructions in the proximal colon are more challenging to treat by stent placement due to the increased distance from the anus.CASE SUMMARY This case report concerns an 88-year-old man with malignant intestinal obstruction in the ileocecal region.He was contraindicated for general anesthesia and surgical enterostomy.The placement of a self-expandable metallic stent seems an alternative to surgery,although stenting in this area is thought to be difficult and few studies have been reported so far.After three attempts at different interventional approaches,a stent was successfully placed in the obstructed segment under fluoroscopic guidance.After the procedure,the patient's abdominal distension and abdominal pain were significantly better than before.CONCLUSION For patients with proximal colonic obstruction,self-expandable metallic stent placement under fluoroscopic guidance could be considered as a feasible treatment to relieve abdominal distension and pain in patients with acute bowel obstruction.It has the characteristics of high safety and high patient tolerance.However,further study is still needed.

A Characteristics-Mix Stabilized Finite Element Method for Variable Density Incompressible Navier-Stokes Equations

This paper describes a characteristics-mix finite element method for the computation of incompressible Navi-er-Stokes equations with variable density. We have introduced a mixed scheme which combines a characteristics finite element scheme for treating the mass conservation equation and a finite element method to deal with the momentum equation and the divergence free constraint. The proposed method has a lot of attractive computational properties: parameter-free, very flexible, and averting the difficulties caused by the original equations. The stability of the method is proved. Finally, several numerical experiments are given to show that this method is efficient for variable density incompressible flows problem.