Hierarchically designed MoWSe_(2)/WO_(3)/C anode for fast and efficient Na+storage

Exploring anode materials with high energy and power density is one of the critical milestones in developing sodium-ion batteries/capacitors(SIBs/SICs).Here,the Mo and W-based bimetallic organic framework(Mo-W-MOF)with core-shell structure is first formed by a facile strategy,followed by a selenization and carbonization strategy to finally prepare multileveled Mo WSe_(2)/WO_(3)/C anode materials with core-shell petal like curled nanosheet structure.Between the petal(MoSe_(2))-core(WO_(3))structure,the formation of WSe_(2)flakes by partial selenization on the surface of WO_(3)serves as a heterogeneous connection between MoSe_(2)and WO_(3).The enlarged layer distance(0.677 nm)between MoSe_(2)and WSe_(2)can facilitate the rapid transfer of Na+and electrons.The density functional theory(DFT)calculations verify that the Mo WSe_(2)/WO_(3)/C heterostructure performs excellent metallic properties.Ex-situ X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and transmission electron microscopy(TEM)confirm the activation process from the initial insertion reaction to the later conversion reaction.Resultantly,when employed as the anode of SIBs,a remarkable capacity of 384.3 mA h g-1after 950 cycles at 10 A g^(-1)is performed.Furthermore,the SICs assembled with commercial activated carbon(AC)as the cathode exhibits a remarkable energy density of 81.86 W h kg^(-1)(at 190 W kg^(-1))and 72.83 W h kg^(-1)(at 3800 W kg^(-1)).The unique structural design and the reaction investigation of the electrode process can provide a reference for the development of transition metal chalcogenides anodes.

原发性肝癌合并脾功能亢进低剂量姑息性放射治疗的临床研究

目的:评价原发性肝癌合并脾功能亢进低剂量姑息性放射治疗的疗效及其临床意义。方法:对我院符合诊断标准的28例原发性肝癌伴脾功能亢进患者三维适形放射治疗,分割剂量2 Gy/次,5次/周,总剂量10~25 Gy,治疗4周中监测白细胞,红细胞,血小板,以及门静脉主干,脾静脉和脾指数等各项指标。结果:28例患者在治疗刚开始1周白细胞、血小板有轻度下降,随后白细胞及血小板开始恢复。放疗前后白细胞、血小板数比较,差异有统计学意义(p>0.05)。治疗后门静脉主干,脾静脉,脾指数均有不同程度缩小,差异有统计学意义(p <0.05)。结论:原发性肝癌导致的脾功能亢进予低剂量姑息性放射治疗可以使脾脏体积和血供减小,白细胞、血小板上升,有效的缓解患者症状。此方法是一种安全、有效的治疗方式,值得临床推广应用。

Idiopathic mesenteric phlebosclerosis associated with long-term use of medical liquor:Two case reports and literature review

A 62-year-old woman was admitted to our hospital in2011 because of recurrent abdominal pain,nausea and constipation for six months.Computed tomography enterography(CTE)showed tortuous thread-like calcifications in the ileocolic vein and right colic vein,while colonoscopy revealed purple-blue mucosa extending from the cecum to the splenic flexure.Based on the results of these tests,the patient was diagnosed with idiopathic mesenteric phlebosclerosis(IMP).She had a history of Chinese medical liquor intake for one and a half years and her symptoms subsided after conservative treatment.In 2013,a 63-year-old male patient who presented with recurrent lower right abdominal pain,bloating,melena and diarrhea for fifteen months was admitted to our institution.Colonoscopy and CTE led to the diagnosis of IMP.He also used Chinese medical liquor for approximately 12 years.The patient underwent total colectomy and the postoperative course was uneventful.We searched for previously published reports on similar cases and analyzed the clinical data of 50 cases identified in PubMed.As some of these patients admitted use of Chinese medicines,we hypothesize that Chinese medicines may play a role in the pathogenesis of IMP.

Prognostic performance of interleukin-10 in patients with chest pain and mild to moderate coronary artery lesions an 8-year follow-up study

BackgroundInterleukin (IL )-10, IL-6 和他们的比率(IL-6/IL-10 ) 在得冠的动脉疾病的风险起一个重要作用，并且可以与它的结果相关。很少临床的试用在与胸 pain.MethodsA 介绍的病人在长期的心血管的事件上调查了这些因素的预示的影响未来的学习在胸疼痛地招收并且识别的 566 个病人上被执行对中等冠的动脉损害温和。IL-10， IL-6 和 IL-6/IL-10 是完成的 511 个病人全部的 measured.ResultsA 后续。中部的后续时间是 74 个月。Kaplan-Meier 分析与 IL-10 的在中部下面的层次在病人在后续时期期间表明了主要不利心脏的事件的发生的清楚的增加(P = 0.006 ) 并且 IL-6/IL-10 的在中部上面的层次(P = 0.012 ) 。比例的危险分析显示了的穆尔蒂瓦里伊特·考克斯是在为内在的 confounders.ConclusionsElevated IL-10 层次的调整以后的强壮的独立预言者的 IL-10 层次胸疼痛地在病人与更有利的长期的预后被联系并且对中等冠的动脉损害温和。IL-10 能被用于对长期的预后的早风险评价。

Hexokinase II promotes the Warburg effect by phosphorylating alpha subunit of pyruvate dehydrogenase

Objective: Tumor cells rely heavily on glycolysis regardless of oxygen tension, a phenomenon called the Warburg effect. Hexokinase II(HKII) catalyzes the first irreversible step of glycolysis and is often overexpressed in tumor cells. Mitochondrial HKII couples glycolysis and oxidative phosphorylation while maintaining mitochondrial membrane integrity. In this study, we investigated the role of HKII in promoting the Warburg effect in cancer cells.Methods: HKII-mediated phosphorylation of the alpha subunit of pyruvate dehydrogenase(PDHA1) was tested in HEK293 T cells and clear cell renal cell carcinoma(cc RCC) specimens using gene knockdown, western blotting,immunohistochemistry, and immunofluorescence.Results: It was determined that HKII could not only transform glucose into glucose-6-phosphate, but also transfer the phosphate group of ATP onto PDHA1. In addition, it was found that HKII increased the phosphorylation of Ser293 on PDHA1, decreasing pyruvate dehydrogenase(PDH) complex activity and thus rerouting the metabolic pathway and promoting the Warburg effect. The overexpression of HKII correlated with the phosphorylation of PDHA1 and disease progression in cc RCC.Conclusions: The data presented here suggest that HKII is an important biomarker in the evaluation and treatment of cancer.

Long-term outcomes of staged recanalization for concurrent chronic total occlusion in patients with ST-segment elevation myocardial infarction after primary percutaneous coronary intervention

Background In patients with acute ST-segment elevation myocardial infarction(STEMI)who undergo primary percutaneous coronary intervention(PCI),approximately 10%are concomitant with a chronic total occlusion(CTO)in a non-culprit vessel.However,the impact of staged CTO recanalization on prognosis in this cohort remains disputable.This study aimed to compare the long-term outcomes of staged CTO recanalization versus medical therapy in patients with STEMI after primary PCI.Methods Between January 2005 and December 2016,a total of 287 patients were treated with staged CTO-PCI(n=91)or medical therapy(n=196)after primary PCI in our center.The primary endpoint was major adverse cardiovascular and cerebrovascular event(MACCE),defined as a composite of all-cause death,nonfatal myocardial infarction(MI),stroke or unplanned revascularization.After propensity-score matching,77 pairs of well-balanced patients were identified.Results The mean follow-up period was 6.06 years.Overall,the incidence of the primary endpoint of MACCE was significantly lower in staged CTO-PCI group than that in medical therapy group in both overall population(22.0%vs.46.9%;hazard ratio(HR)=0.48,95%CI:0.29-0.77)and propensity-matched cohorts(22.1%vs.42.9%;HR:0.48,95%CI:0.27-0.86).In addition,staged CTO-PCI was also associated with reduced risk of the composite of cardiac death,nonfatal MI or stroke compared with medical therapy in both overall population(9.9%vs.26.5%;hazard ratio(HR)=0.39,95%CI:0.19-0.79)and propensity-matched cohorts(9.1%vs.22.1%;HR:0.40,95%CI:0.16-0.96).After correction of the possible confounders,staged CTO-PCI was independently associated with reduced risks of MACCE(adjusted HR:0.46,95%CI:0.28-0.75),the composite of cardiac death,nonfatal MI or stroke(adjusted HR:0.45,95%CI:0.22-0.94)and all-cause mortality(adjusted HR:0.32,95%CI:0.13-0.83).Moreover,the results of sensitivity analysis were almost concordant with the overall analysis.Conclusions In patients with STEMI and a concurrent CTO who undergo primary PCI,successful staged recanalization of CTO in the non-culprit vessels is associated with better clinical outcomes during long-term follow-up.

Development of an improved CBR model for predicting steel temperature in ladle furnace refining

In the prediction of the end-point molten steel temperature of the ladle furnace, the influence of some factors is nonlinear. The prediction accuracy will be affected by directly inputting these nonlinear factors into the data-driven model. To solve this problem, an improved case-based reasoning model based on heat transfer calculation(CBR-HTC) was established through the nonlinear processing of these factors with software Ansys. The results showed that the CBR-HTC model improves the prediction accuracy of end-point molten steel temperature by5.33% and 7.00% compared with the original CBR model and 6.66% and 5.33% compared with the back propagation neural network(BPNN)model in the ranges of [-3, 3] and [-7, 7], respectively. It was found that the mean absolute error(MAE) and root-mean-square error(RMSE)values of the CBR-HTC model are also lower. It was verified that the prediction accuracy of the data-driven model can be improved by combining the mechanism model with the data-driven model.

Long term outcomes of drug-eluting stent versus coronary artery bypass grafting for left main coronary artery disease： a meta-analysis

BackgroundIt 仍然是争论的有 drug-eluting stent ( DES )的经皮的冠的干预是否与冠的动脉相比安全、有效为没有防卫的左主要冠的动脉( ULMCA )绕过接枝外科( CABG )疾病在长期列在后面在上面( 3 年) .MethodsEligible 研究被寻找 PubMed 选择， EMBASE ，并且 Cochrane 图书馆直到2016年12月6日。主要端点是一死亡，心肌的梗塞(MI ) 或在最长的后续期间的击合成。死亡，心脏的死亡， MI，击和重复 revascularization 是第二等的 outcomes.ResultsFour 使随机化的控制试用和包含 14,130 个病人的 12 调整观察研究被包括。DES 比得上关于主要端点的出现的 CABG (HR = 0.94， 95% CI：0.86-1.03 ) 。而且， DES 显著地与 MI 的更高的发生被联系(HR = 1.56， 95% CI：1.09-2.22 ) 并且重复 revascularization (HR = 3.09， 95% CI：2.33-4.10 ) 当没有差别在二策略之间被发现时，与 CABG 相比认为是死亡，心脏的死亡和击的率。而且， DES 能减少死亡， MI 或击的合成端点的风险(HR = 0.80， 95% CI：0.67-0.95 ) 因为有句法的 ULMCA 损害与重复 revascularization 的更高的风险获得 32 .ConclusionsAlthough，有 DES 的一种总线标准看起来象为 ULMCA 疾病在的 CABG 一样安全长期列在后面起来。另外，有 DES 的治疗能是到为 ULMCA 损害与的 CABG 的其他的 interventional 策略对中间的解剖复杂性低。

Application of a hybrid multiscalar indicator in drought identification in Beijing and Guangzhou,China

The Palmer drought severity index(PDSI) is physically based with multivariate concepts, but requires complicated calibration and cannot easily be used for multiscale comparison. Standardized drought indices(SDIs), such as the standardized precipitation index(SPI) and standardized precipitation evapotranspiration index(SPEI), are multiscalar and convenient for spatiotemporal comparison, but they are still challenged by their lack of physical basis. In this study, a hybrid multiscalar indicator, the standardized Palmer drought index(SPDI), was used to examine drought properties of two meteorological stations(the Beijing and Guangzhou stations) in China, which have completely different drought climatologies. The results of our case study show that the SPDI is correlated with the well-established drought indices(SPI, SPEI, and PDSI) and presents generally consistent drought/wetness conditions against multiple indicators and literature records. Relative to the PDSI, the SPDI demonstrates invariable statistical characteristics and better comparable drought/wetness frequencies over time and space. Moreover,characteristics of major drought events(drought class, and onset and end times) indicated by the SPDI are generally comparable to those detected by the PDSI. As a physically-based standardized multiscalar drought indicator, the SPDI can be regarded as an effective development of the Palmer drought indices, providing additional choices and tools for practical drought monitoring and assessment.

2DGE-coomassie brilliant blue staining used to differentiate pasteurized milk from reconstituted milk

Differentiating pasteurized milk and reconsti-tuted milk by scientific approach was necessary to defend consumer from economic fraud of wrong labeling. In this paper 2DGE (2 Dimen-sional Gel Electrophoresis)-coomassie brilliant blue staining method was employed and sig-nificant color intensity changing was observed among raw milk, pasteurized milk, UHT milk and reconstituted milk. For example, the intensity of 10 protein spots including casein and lac-toglobulin reduced more than two folds from pasteurized milk to reconstituted milk. However, DIGE (Differential Gel Electrophoresis) assay showed that the majority protein remained simi-lar level from pasteurized milk to reconstituted milk. Therefore the color fading of coomassie brilliant blue stained 2D gels may be due to other biochemical reaction, such as Maillard reaction, instead of protein degradation. Stability of 2DGE pattern was confirmed by running six gels of the same sample in parallel and software analysis showed that all proteins were at similar level. Two commercialized pasteurized milk samples and one reconstituted milk sample were tested by 2DGE-coomassie blue staining method and re-constituted milk could be easily identified.

Growth differentiation factor-15 is a prognostic marker in patients with intermediate coronary artery disease

Background Growth differentiation factor-15(GDF-15)is involved in multiple processes that are associated with coronary artery disease(CAD).However,little is known about the association between GDF-15 and the future ischemic events in patients with intermediate CAD.This study was conducted to investigate whether plasma GDF-15 constituted risk biomarkers for future cardiovascular events in patients with intermediate CAD.Methods A prospective study was performed based on 541 patients with intermediate CAD(20%–70%).GDF-15 of each patient was determined in a blinded manner.The primary endpoint was major adverse cardiac event(MACE),which was defined as a composite of all-cause death,nonfatal myocardial infarction,revascularization and readmission due to angina pectoris.Results After a median follow-up of 64 months,504 patients(93.2%)completed the follow-up.Overall,the combined endpoint of MACE appeared in 134 patients(26.6%)in the overall population:26 patients died,11 patients suffered a nonfatal myocardial infarction,51 patients underwent revascularization,and 46 patients were readmitted for angina pectoris.The plasma levels of GDF-15(median:1172.02 vs.965.25 pg/m L,P=0.014)were higher in patients with ischemic events than those without events.After adjusting for traditional risk factors,higher GDF-15 levels were significantly associated with higher incidence of the composite endpoint of MACE(HR=1.244,95%CI:1.048–1.478,Quartile 4 vs.Quartile 1,P=0.013).Conclusions The higher level of GDF-15 was an independent predictor of long-term adverse cardiovascular events in patients with intermediate CAD.

A study on the influence mechanism of PBL teaching model on non-English major students＇ critical thinking ability

PBL teaching mode is a kind of emphasis on students＇ independent inquiry based learning approach, which is concerned withthe problem of inquiry and solution process, focusing on the cultivation of students＇ ability. The teaching mode is a new teaching mode basedon the problem and the students as the main body. The open and distance education students of economics as the research object, using the PBLmode of teaching, the results show that the effect of the teaching mode of PBL is obviously better than the traditional teaching mode is helpfulto improve the students＇ ability of autonomous learning, inquiry learning, acquisition, processing and use of statistical information, and theanalysis of the problem, the comprehensive ability to solve problems etc.. The PBL model of critical thinking training includes students＇participation in the setting of goals and problems, group discussion cognitive activities and the reflection and evaluation of teachers and students.

Diagnosing anomalous characteristics of atmospheric water cycle structure during seasonal-scale drought events:A case study in middle and lower reaches of Yangtze River

Anomalous characteristics of the atmospheric water cycle structure are highly significant to the mechanisms of seasonal-scale meteorological droughts.They also play an important role in the identification of indicative predictors of droughts.To better understand the causes of seasonal meteorological droughts in the middle and lower reaches of the Yangtze River(MLRYR),characteristics of the atmospheric water cycle structure at different drought stages were determined using standardized anomalies.The results showed that the total column water vapor(TCWV)was anomalously low during drought occurrence periods.In contrast,there were no anomalous signals at the drought persistence and recovery stages in the MLRYR.Moreover,there was no significant temporal correlation between the TCWV anomaly and seasonal-scale drought index(the 3-month standardized precipitation index(SPI_(3))).During drought events,water vapor that mainly originated from the Bay of Bengal was transported southwest of the MLRYR.Meanwhile,the anomalous signal of water vapor transport was negative at the drought appearance stage.At the drought persistence stage,the negative anomalous signal was the most significant.Water vapor flux divergence in the MLRYR showed significant positive anomalous signals during drought events,and the signal intensity shifted from an increasing to a decreasing trend at different drought stages.In addition,a significant positive correlation existed between the anomaly of water vapor flux divergence and regional SPI_(3).Overall,water vapor flux divergence is more predictive of droughts in the MLRYR.

Measurement and Characterization of Microwave Interaction between Integrated Distributed Feedback Laser Diode and Electro-Absorption Modulator

Integrated electro-absorption-modulated distributed feedback laser diodes(EMLs)are attracting much interest in optical communications for the advantages of a compact structure,low power consumption,and high-speed modulation.In integrated EML,the microwave interaction between the distributed feedback laser diode(DFB-LD)and the electro-absorption modulator(EAM)has a nonnegligible influence on the modulation performance,especially at the high-frequency region.In this paper,integrated EML was investigated as a three-port network with two electrical inputs and a single optical output,where the scattering matrix of the integrated device was theoretically deduced and experimentally measured.Based on the theoretical model and the measured data,the microwave equivalent circuit model of the integrated device was established,from which the microwave interaction between DFB-LD and EAM was successfully extracted.The results reveal that the microwave interaction within integrated EML contains both the electrical isolation and optical coupling.The electrical isolation is bidirectional while the optical coupling is directional,which aggravates the microwave interaction in the direction from DFB-LD to EAM.

A comparison of carotid atherosclerosis in symptomatic patients between 2002-2005 and 2012-2015 cohorts using multi-contrast magnetic resonance vessel wall imaging

OBJECTIVE To compare the morphological and compositional characteristics of carotid plaques in two cohorts(2002−2005 and 2012−2015)of Chinese patients using magnetic resonance vessel wall imaging.METHODS Symptomatic patients with carotid atherosclerotic plaques who underwent carotid vessel wall magnetic resonance imaging between 2002−2005 and 2012−2015 were retrospectively recruited.Plaque morphology[including mean wall area,wall thickness,and maximum normalized wall index(NWI)]and composition[including calcification,intraplaque hemorrhage,and lipid-rich necrotic core(LRNC)]in symptomatic carotid arteries were evaluated and compared between patients in these two time periods.RESULTS A total of 258 patients,including 129 patients in the 2002−2005 cohort and 129 patients in the 2012−2015 cohort,were recruited.Statin use(49.6%vs.32.6%,P=0.004)and hypertension(76.0%vs.62.8%,P=0.015)were significantly more common in the 2012-2015 cohort than in the 2002−2005 cohort.Patients in the 2012−2015 cohort also exhibited significantly low plaque burden parameters(all P<0.05),as well as a lower prevalence(68.2%vs.89.9%,P<0.001)and volume percentages of LRNC(11.2%±14.2%vs.25.7%±17.7%,P<0.001).These differences remained significant after adjustment for clinical factors.The differences in the volume percentages of LRNC also remained significant after an additional adjustment for maximum NWI(P<0.001).CONCLUSIONS Patients in the 2012−2015 cohort had a lower plaque burden and volume percentages of LRNC in symptomatic carotid arteries than those in the 2002−2005 cohort.These findings indicate that carotid plaques in the recent cohort had a lower severity and vulnerability.

Coordinated Control of Multi-FACTS to Enhance the Dynamic Stability of the Power System

This article introduces a FACTS coordinated control strategy with impedance/admittance measurement feedback. Then the effectiveness of this method is proved in mathematics with damp torque method. The control strategy effect is verified in a single machine infinite bus system and a four machine power system with PSASP6.26 (Power System Analysis Software Package). This coordinated control strategy has practical significance to improve system dynamic stability and theoretical significance to improve system transient stability.

Mobile Backhaul Solutions

In this paper, we give an overview of mobile backhaul solutions and propose an MPLS-centered solution that takes intoaccount timing synchronization, OAM, and protection： We also propose an evolved protection bandwidth allocation mechanism that makes the transport network as efficient as possible.

An antibody cocktail with broadened mutational resistance and effective protection against SARS-CoV-2

Neutralizing antibodies have been proven to be highly effective in treating mild and moderate COVID-19 patients,but continuous emergence of SARS-CoV-2 variants poses significant challenges.Antibody cocktail treatments reduce the risk of escape mutants and resistance.In this study,a new cocktail composed of two highly potent neutralizing antibodies(HB27 and H89Y)was developed,whose binding epitope is different from those cocktails that received emergency use authorization.This cocktail showed more potent and balanced neutralizing activities(IC_(50)0.9–11.3 ng mL^(-1))against a broad spectrum of SARS-CoV-2 variants over individual HB27 or H89Y antibodies.Furthermore,the cocktail conferred more effective protection against the SARS-CoV-2 Beta variant in an aged murine model than monotherapy.It was shown to prevent SARS-CoV-2 mutational escape in vitro and effectively neutralize 61 types of pseudoviruses harbouring single amino acid mutation originated from variants and escape strains of Bamlanivimab,Casirivimab and Imdevimab with IC_(50)of 0.6–65 ng mL^(-1).Despite its breadth of variant neutralization,the HB27+H89Y combo and EUA cocktails lost their potencies against Omicron variant.Our results provide important insights that new antibody cocktails covering different epitopes are valuable tools to counter virus mutation and escape,highlighting the need to search for more conserved epitopes to combat Omicron.