The high incidence and disability rates of stroke pose a heavy burden on society.Inflammation is a significant pathological reaction that occurs after an ischemic stroke.Currently,therapeutic methods,except for intrav...The high incidence and disability rates of stroke pose a heavy burden on society.Inflammation is a significant pathological reaction that occurs after an ischemic stroke.Currently,therapeutic methods,except for intravenous thrombolysis and vascular thrombectomy,have limited time windows.Mesenchymal stem cells(MSCs)can migrate,differentiate,and inhibit inflammatory immune responses.Exosomes(Exos),which are secretory vesicles,have the characteristics of the cells from which they are derived,making them attractive targets for research in recent years.MSC-derived exosomes can attenuate the inflammatory response caused by cerebral stroke by modulating damage-associated molecular patterns.In this review,research on the inflammatory response mechanisms associated with Exos therapy after an ischemic injury is discussed to provide a new approach to clinical treatment.展开更多
Coronavirus disease 2019(COVID-19)has affected the quality of sleep for various populations,causing anxiety and depression world-wide.COVID-19–related insomnia(COVIDRI)appears to be more common in certain populations...Coronavirus disease 2019(COVID-19)has affected the quality of sleep for various populations,causing anxiety and depression world-wide.COVID-19–related insomnia(COVIDRI)appears to be more common in certain populations,including females,urban residents and other individuals who reside in high-risk COVID-19–related areas,lack higher socioeconomic and educational levels,have a history of underlying mental illness,have no access to social support and work,or have been mandated for isolation.Among vulnerable pop-ulations,pregnant women,adolescents and children are more likely to suffer from anxiety and depression,which leads to irregular sleep-wake cycles and significantly poor sleep quality.Insomnia in COVID-19 patients is associated with decreased immune levels,ex-cessive psychological stress and severe anxiety.The COVIDRI incidence and severity among frontline healthcare workers is high,espe-cially among females and those working in isolation wards and intensive care units.The factors related to COVIDRI for college students during home study are stress from upcoming graduation,disharmonious family relationships and inadaptability to online education.For military personnel,anxiety and depression are the main causes of poor sleep quality.Based on the characteristics of different popula-tions,active Chinese and Western medications,non-drug therapy,psychological counseling and suitable sleep management are vital measures to strengthen immunity,alleviate insomnia and limit recurrence.展开更多
基金National Natural Science Foundation of China,No.81974564 and No.82104730the Zhongyuan Science and Technology Innovation Leading Talent Project,No.224200510027+2 种基金the National Natural Science Foundation of China,No.82001973the Youth Project Co-established by Henan Province and a Ministry grant,No.SBGJ2020003017the Health Science and Technology Innovation Excellent Youth Training Project in Henan Province,No.YXKC2020057.
文摘The high incidence and disability rates of stroke pose a heavy burden on society.Inflammation is a significant pathological reaction that occurs after an ischemic stroke.Currently,therapeutic methods,except for intravenous thrombolysis and vascular thrombectomy,have limited time windows.Mesenchymal stem cells(MSCs)can migrate,differentiate,and inhibit inflammatory immune responses.Exosomes(Exos),which are secretory vesicles,have the characteristics of the cells from which they are derived,making them attractive targets for research in recent years.MSC-derived exosomes can attenuate the inflammatory response caused by cerebral stroke by modulating damage-associated molecular patterns.In this review,research on the inflammatory response mechanisms associated with Exos therapy after an ischemic injury is discussed to provide a new approach to clinical treatment.
基金supported by the Comparative Study on Traditional Chinese Medicine Technical Intervention and Management of Chronic Insomnia in Henan University of Chinese Medicine(2019JDZX2007)Evaluation of Therapeutic Effect of Shugan Jianpi Yangxin Prescription on Insomnia Disorder Insomnia inHenan University of Chinese Medicine(2022JDZX004)+1 种基金National Natural Science Foundation of China(82104730)China Postdoctoral Science Foundation(2022M721065)。
文摘Coronavirus disease 2019(COVID-19)has affected the quality of sleep for various populations,causing anxiety and depression world-wide.COVID-19–related insomnia(COVIDRI)appears to be more common in certain populations,including females,urban residents and other individuals who reside in high-risk COVID-19–related areas,lack higher socioeconomic and educational levels,have a history of underlying mental illness,have no access to social support and work,or have been mandated for isolation.Among vulnerable pop-ulations,pregnant women,adolescents and children are more likely to suffer from anxiety and depression,which leads to irregular sleep-wake cycles and significantly poor sleep quality.Insomnia in COVID-19 patients is associated with decreased immune levels,ex-cessive psychological stress and severe anxiety.The COVIDRI incidence and severity among frontline healthcare workers is high,espe-cially among females and those working in isolation wards and intensive care units.The factors related to COVIDRI for college students during home study are stress from upcoming graduation,disharmonious family relationships and inadaptability to online education.For military personnel,anxiety and depression are the main causes of poor sleep quality.Based on the characteristics of different popula-tions,active Chinese and Western medications,non-drug therapy,psychological counseling and suitable sleep management are vital measures to strengthen immunity,alleviate insomnia and limit recurrence.
