The hydrosulfonylation of terminal alkynes employing sulfonohydrazides has been accomplished with cop- per-catalysis in the presence of BPO （benzoic peroxyanhydride）. Generally, excellent yield of the vinyl sulfone ...The hydrosulfonylation of terminal alkynes employing sulfonohydrazides has been accomplished with cop- per-catalysis in the presence of BPO （benzoic peroxyanhydride）. Generally, excellent yield of the vinyl sulfone products has been acquired by heating the reaction at 70℃ in DMSO.展开更多
Oxygen deficiency is a major obstacle to hypoxic-related cancer theranostics,and developing the oxygen production nanoplatforms received the widespread attention.However,it is remaining a challenge to structure a nano...Oxygen deficiency is a major obstacle to hypoxic-related cancer theranostics,and developing the oxygen production nanoplatforms received the widespread attention.However,it is remaining a challenge to structure a nanoplatform with hypoxia alleviation effect and imaging-guided cancer radiotherapy.Herein,we present a novel theranostics nanoplatform(Au NPs/UCNPs/WO_(3)@C)comprising of tungsten trioxide(WO3)that loaded gold nanoparticles(Au NPs)and up-conversion nanoparticles(UCNPs)for improved photoacoustic(PA)imaging performance in the second near infrared window(NIR-Ⅱ,900-1,700 nm).Au NPs/UCNPs/WO_(3)@C exhibited superior oxygen-generation effect and doxorubicin loading capacity,thus serving as an efficient radiosensitizer for radio-chemo anti-cancer therapy.Importantly,the accumulated Au NPs/UCNPs/WO_(3)@C in the tumor region led to the increased NIR-Ⅱ PA imaging signal and the blood oxygen saturation signal,which could enhance radiation sensitivity and accurately guiding cancer radiotherapy to reduce side effects on normal tissues.This study with proof-of-concept confirmed the multifaceted characteristics and encouraging potential of biomimetic Au NPs/UCNPs/WO_(3)@C for NIR-Ⅱ PA imaging-guided tumor therapeutics.展开更多
基金This work is financially supported by the National Natural Science Foundation of China （No. 21562024）.
文摘The hydrosulfonylation of terminal alkynes employing sulfonohydrazides has been accomplished with cop- per-catalysis in the presence of BPO （benzoic peroxyanhydride）. Generally, excellent yield of the vinyl sulfone products has been acquired by heating the reaction at 70℃ in DMSO.
基金This research was supported by the National Natural Science Foundation of China(Nos.22027805 and 21874024)the National Key R&D Program of China(No.2020YFA0210800)+1 种基金the joint research projects of Health and Education Commission of Fujian Province(No.2019-WJ-20)the Natural Science Foundation of Fujian Province(No.2020J02012).
文摘Oxygen deficiency is a major obstacle to hypoxic-related cancer theranostics,and developing the oxygen production nanoplatforms received the widespread attention.However,it is remaining a challenge to structure a nanoplatform with hypoxia alleviation effect and imaging-guided cancer radiotherapy.Herein,we present a novel theranostics nanoplatform(Au NPs/UCNPs/WO_(3)@C)comprising of tungsten trioxide(WO3)that loaded gold nanoparticles(Au NPs)and up-conversion nanoparticles(UCNPs)for improved photoacoustic(PA)imaging performance in the second near infrared window(NIR-Ⅱ,900-1,700 nm).Au NPs/UCNPs/WO_(3)@C exhibited superior oxygen-generation effect and doxorubicin loading capacity,thus serving as an efficient radiosensitizer for radio-chemo anti-cancer therapy.Importantly,the accumulated Au NPs/UCNPs/WO_(3)@C in the tumor region led to the increased NIR-Ⅱ PA imaging signal and the blood oxygen saturation signal,which could enhance radiation sensitivity and accurately guiding cancer radiotherapy to reduce side effects on normal tissues.This study with proof-of-concept confirmed the multifaceted characteristics and encouraging potential of biomimetic Au NPs/UCNPs/WO_(3)@C for NIR-Ⅱ PA imaging-guided tumor therapeutics.
