Nursing Experience of an Elderly Patient with Systemic Disseminated <i>Penicillium marneffei</i>

Elderly patients with systemic disseminated Penicillium marneffei are generally more seriously ill with high mortality. In addition to clear diagnosis and timely treatment, careful nursing throughout the hospitalization is particularly important for the patient’s recovery. Psychological nursing and family emotional support, the treatment of adverse drug reactions, systemic infection wound care, the prevention of pressure sores in long-term bedridden patients, antithrombotic nursing, disinfection isolation and the standard prevention of nosocomial cross infection all play decisive roles in the patient’s prognosis. After one month treatment and medical care, the patient was cured and was discharged from hospital. After discharge, the patient follow-up was carried out up to one year. This patient had completely recovered. In this paper, we report a successful nursing experience of an elderly patient with systemic disseminated Penicillium marneffei. With the summary of nursing key points, it could play a reference in the treatment and rehabilitation of similar patients.

Psychological Study of a Patient with COVID-19 at the Early Stage of the Epidemic

Coronavirus disease-2019 (COVID-19) caused by novel coronavirus 2019 (2019-nCoV) has led to 199,466,211 confirmed cases, including 4,244,541 deaths by 6:44 pm CEST. This epidemic is now on the period of global outbreak, the control of COVID-19 has severely challenged the world. At the beginning of the outbreak, patients infected or suspected were observed and close contacts were isolated. The country delayed the resumption of work and school and all walks of life are seriously affected. All kinds of true and false information and rumours on the internet exist, aggravating people’s anxiety and restlessness. These factors altogether often induce people to feel various negative emotions and psychological problems. In this paper, a patient with COVID-19 was examined through psychological dynamic observation at the beginning of the epidemic. It was found that in the early stage of the epidemic, due to the lack of clear treatment guidelines, the main treatment methods and psychological problems were the main reasons affecting the recovery of patients. Many uncertain factors, including individual and social factors and quarantine, worry about the prognosis, etc, resulting in anxiety, fear, unacceptance, insomnia, irritability and other pessimistic moods. After 16 days of symptomatic treatment, psychological counselling and adjustments in a timely manner, the patient eventually recovered and was discharged. The discussion of this case could serve as a reference for the treatment and rehabilitation of patients with COVID-19 in other countries and regions.

两种含氯消毒副产物对草履虫急性毒性效应初探

氯化消毒是我国普遍采用的城市污水消毒措施,然而,氯化消毒的同时,氯与水中的有机物发生反应生成一系列的卤代烃类化合物,即氯化消毒副产物。经研究证实大部分氯化消毒副产物具有致癌、致突变、生殖毒性效应。为研究消毒废水中一些副产物的毒性,本研究采用消毒废水中的有害副产物三氯甲烷(CHCl3)和三溴甲烷(CHBr3)为毒物材料,以草履虫为受试生物,对其种群进行单一急性毒性和联合毒性实验,探究CHCl3和CHBr3对草履虫的急性毒性和联合毒性。实验结果表明,两种毒物单独作用时,随着浓度增大,毒性作用也增大,CHCl3的1 h半致死浓度(LC50)为1585.27 μg/L,CHBr3的1 h半致死浓度(LC50)为656.37 μg/L,两种毒物共同作用时表现为协同作用。由于草履虫对两种毒物毒性较为敏感,其可作为CHCl3和CHBr3的毒性评价生物。

Improving the activity of electrochemical reduction of CO_(2) to C_(1) products by oxidation derived copper catalyst

Cu-based electrocatalysts have become the focus in the field of electrochemical CO_(2) reduction reaction(ECO_(2) RR)due to their ability to produce multicarbon products.However,the research on generating single carbon products with higher economic feasibility via ECO_(2) RR based on Cu-based electrocatalysts is rather rare,and the roles of the surface architecture and oxides of the electrocatalysts have not been explained exactly.In this work,a two-step method including thermal oxidation and electroreduction is proposed to introduce Cuþinto pure Cu foil to form Cu_(2)O/Cu electrocatalyst.By regulating the surface composition and morphology of the electrocatalyst in this way,the activity of ECO 2 RR to C_(1) products has been greatly improved.The Faradaic efficiency of carbon products of the Cu_(2)O/Cu electrode reaches 84%at?0.7 V vs.RHE with good selectivity for HCOOH and CO.The current density of Cu_(2)O/Cu electrode reaches-12.21 mA cm^(2) at-0.8 V vs.RHE,which is much higher than that of the Cu foil electrode(?0.09 mA cm?2).In-situ Raman characterization shows that Cuþin Cu_(2)O/Cu electrode could inhibit hydrogen generation and promote ECO_(2) RR by stabilizing the adsorption of CO_(2).

Modified Z-Plasty for Reconstruction of Webbed Scar Contractures

Rationale: Webbed scar contractures deformity caused by burns and other factors will lead to joint disorders and affect the mental health of patients, resulting in a severe decline in quality of life. Rapid, effective and less complicated surgical methods can help patients with post-burn rehabilitation. Objective: This article argues that a modified Z-plasty can quickly improve the range of motion caused by webbed scar contractures in joint areas, including surgical methods, postoperative care and prognosis. Methods and Results: The study took place from 2018 to 2022. Thirty-two patients with joint scar contracture deformity, with a mean age of 32.5 years, were included in the study. All patients underwent contracture scar revision and modified Z-plasty repair under anesthesia. All the flaps survived and the joint function was improved. Compared with the traditional Z-plasty, the duration of the operative procedure of the modified Z-plasty was significantly shorter, more surrounding scar tissue was mobilized, and the effectiveness of postoperative scar contracture release was better. Discussions: The modified Z-plasty for scar contracture deformity in joint area is simple, rapid, effective and easy to manage.

MOF衍生Co_(3)O_(4)/ZrO_(2)介孔八面体:优化电荷转移和中间体转化用于高效CO_(2)光还原

调控电荷转移和反应路径是促进光催化CO_(2)还原的两种有效策略.本研究通过热解UIO-66@ZIF-67核壳八面体,合成了Co_(3)O_(4)/ZrO_(2)介孔八面体.该介孔八面体由高度分散的小尺寸纳米颗粒组装而成,平均颗粒尺寸为13 nm,平均孔径为5.8 nm,比表面积为43.11 m^(2)g^(-1).受益于活性位点设计,电荷转移动力学和CO_(2)吸附得以增强.此外,密度泛函理论计算结果显示,ZrO_(2)能够有效调控CO_(2)还原的反应路径,包括促进CO_(2)活化为*CO_(2)、中间体(*COOH和*CO)的形成、以及减小限速步(*CO→CO)的能垒.因此,Co_(3)O_(4)/ZrO_(2)介孔八面体的周转率高达28.82,是纯Co_(3)O_(4)的16.95倍.

Dynamic 3D shape reconstruction under complex reflection and transmission conditions using multi-scale parallel single-pixel imaging

Depth measurement and three-dimensional(3D)imaging under complex reflection and transmission conditions are challenging and even impossible for traditional structured light techniques,owing to the precondition of point-to-point triangulation.Despite recent progress in addressing this problem,there is still no efficient and general solution.Herein,a Fourier dual-slice projection with depth-constrained localization is presented to separate and utilize different illumination and reflection components efficiently,which can significantly decrease the number of projection patterns in each sequence from thousands to fifteen.Subsequently,multi-scale parallel single-pixel imaging(MS-PSI)is proposed based on the established and proven position-invariant theorem,which breaks the local regional assumption and enables dynamic 3D reconstruction.Our methodology successfully unveils unseen-before capabilities such as(1)accurate depth measurement under interreflection and subsurface scattering conditions,(2)dynamic measurement of the time-varying high-dynamic-range scene and through thin volumetric scattering media at a rate of 333 frames per second;(3)two-layer 3D imaging of the semitransparent surface and the object hidden behind it.The experimental results confirm that the proposed method paves the way for dynamic 3D reconstruction under complex optical field reflection and transmission conditions,benefiting imaging and sensing applications in advanced manufacturing,autonomous driving,and biomedical imaging.

Circular RNA ubiquitin-associated protein 2 enhances autophagy and promotes colorectal cancer progression and metastasis via miR-582-5p/FOXO1 signaling

Numerous circular RNAs(circ RNAs) have been identified as vital regulators in various cancers. The newly reported circular RNA ubiquitin-associated protein 2(circ UBAP2) is a critical player in cell growth and metastasis in various types of cancers, although its role in colorectal cancer(CRC) has yet to be fully elucidated. We find that circ UBAP2 is upregulated in CRC tissues and cell lines to induce autophagy both in vitro and in vivo. The effects of circ UBAP2 on migration, invasion, and proliferation may be partially related to autophagy. Mechanistically, we uncover that circ UBAP2 can directly interact with mi R-582-5 p and subsequently act as a micro RNA sponge to regulate the expression of the mi R-582-5 p target gene forkhead box protein O1(FOXO1) and downstream signaling molecules, which collectively advance the progression and metastasis of CRC. These results suggest that circ UBAP2 acts as an oncogene via a novel circ UBAP2/mi R-582-5 p/FOXO1 axis, providing a potential biomarker and therapeutic target for CRC management.

ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles

Similar to that of other enteroviruses, the replication of enterovirus 71(EV71) occurs on rearranged membranous structures called replication organelles(ROs). Phosphatidylinositol 4-kinase Ⅲ(PI4KB), which is required by enteroviruses for RO formation, yields phosphatidylinositol-4-phosphate(PI4P) on ROs. PI4P then binds and induces conformational changes in the RNA-dependent RNA polymerase(Rd Rp) to modulate Rd Rp activity. Here, we targeted 3D polymerase, the core enzyme of EV71 ROs, and found that the host factor Annexin A2(ANXA2) can interact with 3 D polymerase and promote the replication of EV71. Then, an experiment showed that the annexin domain of ANXA2, which possesses membranebinding capacity, mediates the interaction of ANXA2 with EV71 3 D polymerase. Further research showed that ANXA2 is localized on ROs and interacts with PI4KB. Overexpression of ANXA2 stimulated the formation of PI4P, and the level of PI4P was decreased in ANXA2-knockout cells. Furthermore, ANXA2, PI4KB, and 3D were shown to be localized to the viral RNA replication site, where they form a higher-order protein complex, and the presence of ANXA2 promoted the PI4 KB-3D interaction. Altogether, our data provide new insight into the role of ANXA2 in facilitating formation of the EV71 RNA replication complex.

The electromechanical features of LiNbO_(3) crystal for potential high temperature piezoelectric applications

Lithium niobate(LiNbO_(3),LN)crystal is a multi-functional material with favorable piezoelectric,nonlinear optical and electro-optic properties.In this study,the electromechanical properties of the radial extensional(RE)and the thickness extensional(TE)modes of the congruent LN are studied and the temperature dependent behaviors are revealed.The RE mode electromechanical coupling factors(kp)for the Y-and Z-oriented discs are calculated and found to be 3.8%and 24.7%,respectively,which are nearly the same as the experimental results of 3.8%and 25.2%,respectively.The maximum RE and thickness shear(TS)modes electromechanical coupling factors are obtained to be 47.6%and 68.5%for the Yx/25
and Yx/167
crystal cuts,respectively.The LN crystal possesses good temperature stability of the electromechanical coupling factors(RE and TE modes)from 20℃ to 500℃,where the variations of kp and kt for the Y-oriented discs are<8.0%and<1.8%,respectively.

Electrical properties of yttrium calcium oxyborate crystal annealed at high temperature and low oxygen partial pressure

The yttrium calcium oxyborate crystal(YCa_(4)O(BO_(3))_(3),YCOB)has been actively studied for hightemperature piezoelectric sensing applications.In this work,the stability of electric properties of YCOB crystal annealed in critical conditions(high-temperatures of 900-1100℃ with a low oxygen partial pressure of 4×10^(-6) atm for 24 h)was investigated and the recovery mechanism for the electrical resisitivity,dielectric permittivity and dielectric loss were studied,taking advantage of the X-ray photoelectron spectra and the first principle calculations.The electrical resistivity of the annealed YCOB crystal was slightly decreased when compared to the pristine counterpart,being(2-5)×10^(7) Ω·cm at 850
C.The dielectric permittivity and dielectric loss were found to increase after annealing,showing recoverable behaviours after thermal treatment above 650℃ in air.The calculated vacancy formation energy indicates that the oxygen vacancy is the dominant defects in YCOB.The formation of oxygen vacancy weakens the chemical bonding strength between B(Ca or Y)and O atoms,introduces extra donor levels in the band gap,which excites the electrons to conduction band more easily thus enhances the electrical conductivity and dielectric loss.The recovered electrical properties are believed to be associated with the reduced vacancy defects at elevated temperatures in air.

Temperature dependent behaviors of electro-elastic properties of NdCa_(4)O(BO_(3))_(3)crystal with monoclinic symmetry

Rare-earth calcium oxyborate crystals(RECa_(4)O(BO_(3))_(3),RECOB,RE:rare-earth elements)are a kind of multifunctional crystal materials.In this work,the temperature dependent behaviors of the electroelastic constants of NdCOB crystal were investigated over the temperature range of-80-200℃,and their temperature coefficients were evaluated.It is found that NdCOB crystal possesses minimal variation of relative dielectric permittivities(<3%).The temperature coefficient of frequency for ZY cut with width shear vibration mode is in the order of 0.07×10^(-4)/℃.The temperature coefficients of the elastic compliances are obtained to be in the range of-33.0×10^(-4)/℃-32.2×10^(-4)/℃.Particularly,the sand swere found to show low temperature coefficients of the elastic compliances,i.e.1.0×10^(-4)/℃and-0.4×10^(-4)/℃,respectively,indicating the existence of zero temperature coefficient of frequency crystal cut.Furthermore,the electromechanical coupling factors and piezoelectric coefficients as a function of temperature were studied.The electromechanical coupling factor kand piezoelectric coefficient dare determined to be~30.8%and~15.2 pC/N at room temperature,respectively.The large piezoelectric response and zero temperature coefficient of frequency indicate the potential usage of NdCOB crystal for piezoelectric frequency devices over a wide temperature range.

Aided innovative design of bathroom products based on artificial intelligence technology

Artificial intelligence technology, mainly refers to strengthening the artificial way, so as to combinecomputer technology with product design. Firstly, the auxiliary innovation of bathroomproducts based on artificial intelligence technology is proposed, then the user characteristicsare analysed, and the auxiliary design framework of bathroom products is designed. Finally, theinnovation model is established to realise the auxiliary innovation design of bathroom products.Experimental results show that the proposed method can effectively improve the interactionefficiency and response time, and reduce the false response.

White light emission from Er, Pr co-doped AlN films

In this work, Er-doped aluminum nitride(AlN), Pr-doped AlN, and Er, Pr co-doped AlN thin films were prepared by ion implantation. After annealing, the luminescence properties were investigated by cathodoluminescence. Some new and interesting phenomena were observed. The peak at 480 nm was observed only for Er-doped AlN. However, for Er, Pr co-doped AlN, it disappeared. At the same time, a new peak at 494 nm was observed,although it was not observed for Er-doped AlN or Pr-doped AlN before. Therefore, the energy transfer mechanism between Er^3+and Pr^3+in AlN thin films was investigated in detail. Through optimizing the dose ratio of Er^3+with respect to Pr^3+, white light emission with an International Commission on Illumination chromaticity coordinate(0.332, 0.332) was obtained. This work may provide a new strategy for realizing white light emission based on nitride semiconductors.

Multifunctional biocatalysis:An unusual imine reductase

A multifunctional biocatalyst EneIRED capable of catalyzing amine-activated conjugate alkene reduction and subsequent reductive amination was discovered.The enzyme realized the coupling ofα,β-unsaturated carbonyls with amines to efficiently synthesize a broad set of chiral amine diastereomers based on its unusual active site structure and catalytic mechanism.

Novel agents for multiple myeloma with extramedullary disease

Multiple myeloma(MM)is the second most common hematological malignancy.The introduction of proteasome inhibitors(PIs)and immunomodulatory drugs(IMiDs)greatly improved the outcomes for these patients.Extramedullary disease(EMD),an aggressive manifestation of MM,remains a significant treatment challenge.Recently,active clinical development of remarkable novel agents for MM with new mechanisms of action has begun.These agents show promising anti-MM effects and provide the opportunity to extend the survival of patients.They include next-generation PIs and IMiDs;monoclonal antibodies;chimeric antigen receptor T cells;antibody-drug conjugates;bispecific T cell engager antibodies;and small molecular inhibitors.However,few clinical trials have focused on patients with EMD,and the effectiveness of these agents has not been well evaluated and compared in these patients.In this review,we summarize the efficacy of these novel agents in MM patients with EMD.