Objectives:Distolingual root of the permanent mandibular first molar(PMFM-DLR)has been frequently reported,which may complicate the treatment of periodontitis.This study aimed to assess the morphological features of P...Objectives:Distolingual root of the permanent mandibular first molar(PMFM-DLR)has been frequently reported,which may complicate the treatment of periodontitis.This study aimed to assess the morphological features of PMFM-DLR and investigate the correlation between the morphological features of PMFM-DLR and periodontal status in patients with Eastern Chinese ethnic background.Materials and methods:A total of 836 cone beam computed tomography(CBCT)images with 1497 mandibular first molars were analyzed to observe the prevalence of PMFM-DLR at the patients and tooth levels in Eastern China.Among them,complete periodontal charts were available for 69 Chinese patients with 103 teeth.Correlation and regression analyses were used to evaluate the correlation between the morphological features of DLR,bone loss,and periodontal clinical parameters,including clinical attachment loss(CAL),probing pocket depth(PPD),gingival recession(GR),and furcation involvement(FI).Results:The patient-level prevalence and tooth-level prevalence of DLR in mandibular first molars were 29.4%and 26.3%,respectively.Multiple linear regression analysis suggested that bone loss at the lingual site and CAL were negatively affected by the angle of separation between distolingual and mesial roots in the transverse section,while they were significantly influenced by age and the angle of separation between distobuccal and mesial roots in the coronal section.Conclusions:The prevalence of PMFM-DLR in Eastern China was relatively high in our cohort.The morphological features of DLR were correlated with the periodontal status of mandibular first molars.This study provides critical information on the morphological features of DLR for improved diagnosis and treatment options of mandibular molars with DLR.展开更多
The majority of hepatocellular carcinoma(HCC)cases are diagnosed at an advanced stage.Currently,there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis(EHM).System...The majority of hepatocellular carcinoma(HCC)cases are diagnosed at an advanced stage.Currently,there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis(EHM).Systemic chemotherapy,such as FOLFOX4(infusions of fluorouracil,leucovorin,and oxaliplatin),has been reported for treating advanced HCC with EHM,but its effectiveness is very poor.展开更多
The performance of asymmetric supercapacitors(ASCs)is strongly restricted by the capacity gap between the positive and negative electrodes.To address this issue,two new electrode materials deriving from Co‐and Fe‐ba...The performance of asymmetric supercapacitors(ASCs)is strongly restricted by the capacity gap between the positive and negative electrodes.To address this issue,two new electrode materials deriving from Co‐and Fe‐based metal–organic frameworks(MOFs,Co‐TAMBA‐d,and Fe‐TAMBA‐d)through a single‐step sintering method have been developed by considering the superiorities of the derivatives of MOFs including large surface areas,sufficient metal‐atom‐doping content,and extreme surface wettability to the bath solution.The as‐prepared Co‐TAMBA‐d as a positive electrode delivers typical pseudocapacitive behavior with the improvement of capacity,which is better than those of pristine MOF materials,while Fe‐TAMBA‐d as negative electrodes displays better electrochemical behavior than those of activated carbon.ASCs based on these two electrodes exhibits excellent energy density and power density of 47Wh/kg and 1658 W/kg,respectively,where this device can maintain prominent cycling stability with capacity retention after 5000 cycles being about 75%.Furthermore,the capacity can feed a series of red light‐emitting diodes,which gives solid evidence of the potential utilization.These results can afford the feasibility of isostructural MOF derivatives as promising electrodes in novel ASCs.展开更多
Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not satisfactory.The study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to ...Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not satisfactory.The study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to infusional fluorouracil,leucovorin,and oxaliplatin(FOLFOX4)for advanced hepatocellular carcinoma(HCC).Methods:We extracted the data of patients with advanced HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus FOLFOX4 at the Eastern Hepatobiliary Surgery Hospital,First Hospital of Jilin University,and Zhejiang Sian International Hospital and retrospectively compared for overall survival.The Cox proportional hazards model was used to calculate the hazard ratios for overall survival and disease progression after controlling for age,sex,and disease stage.Results:From July 2013 to July 2018,111 patients with HCC were included in this study.The median survival duration was 14.8 months in the ATRA plus FOLFOX4 group and 8.2 months in the FOLFOX4 only group(P<0.001).The ATRA plus FOLFOX4 group had a significantly longer median time to progression compared with the FOLFOX4 group(3.6 monthsvs.1.8 months,P<0.001).Hazard ratios for overall survival and disease progression were 0.465(95%confidence interval:0.298–0.726;P=0.001)and 0.474(0.314–0.717;P<0.001)after adjusting for potential confounders,respectively.Conclusion:ATRA plus FOLFOX4 significantly improves the overall survival and time to disease progression in patients with advanced HCC.展开更多
Micron/nano scale topographic modification has been a significant focus of interest in current titanium(Ti)surface design.However,the influence of micron/nano structured surface on cell or bacterium behavior on the Ti...Micron/nano scale topographic modification has been a significant focus of interest in current titanium(Ti)surface design.However,the influence of micron/nano structured surface on cell or bacterium behavior on the Ti implant has rarely been systematically evaluated.Moreover,except for popular microgrooves,little work has been carried out on the reaction of cells to the bionic structure.In this study,several micro-pillars mimicking cell morphology were prepared on Ti surfaces by lithography and contact printing(ICP)method,and they were further decorated with nanotube arrays by anodization technology.These surface modifications remarkablly increased the surface roughness of pristine Ti surface from 91.17 nm±5.57 nm to be more than 1000 nm,and reduced their water contact angles from 68.3°±0.7°to be 16.9°±2.4°.Then,the effects of these hierarchical micron/nano scale patterns on the behaviors of MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and P.gingivalis were studied,aiming to evaluate their performance in osseointegration,gingival epithelial sealing and antibacterial ability.Through an innovative scoring strategy,our findings showed that square micro-pillars with 6μm width and 2μm height combined with 85 nm diameter nanotubes was suitable for implant neck design,while square micro-pillars with 3μm width and 3.6μm height combined with 55 nm diameter nanotubes was the best for implant body design.Our study reveals the synergistic effect of the hierarchical micron/nano scale patterns on MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and P.gingivalis functions.It provides insight into the design of biomedical implant surfaces.展开更多
基金The study protocol has been reviewed and approved by the Ethics Committee of the Stomatology Hospital,Zhejiang University School of Medicine(No.2023-031)and registered in Chinese Clinical Trial Registry(No.ChiCTR2300074445).
文摘Objectives:Distolingual root of the permanent mandibular first molar(PMFM-DLR)has been frequently reported,which may complicate the treatment of periodontitis.This study aimed to assess the morphological features of PMFM-DLR and investigate the correlation between the morphological features of PMFM-DLR and periodontal status in patients with Eastern Chinese ethnic background.Materials and methods:A total of 836 cone beam computed tomography(CBCT)images with 1497 mandibular first molars were analyzed to observe the prevalence of PMFM-DLR at the patients and tooth levels in Eastern China.Among them,complete periodontal charts were available for 69 Chinese patients with 103 teeth.Correlation and regression analyses were used to evaluate the correlation between the morphological features of DLR,bone loss,and periodontal clinical parameters,including clinical attachment loss(CAL),probing pocket depth(PPD),gingival recession(GR),and furcation involvement(FI).Results:The patient-level prevalence and tooth-level prevalence of DLR in mandibular first molars were 29.4%and 26.3%,respectively.Multiple linear regression analysis suggested that bone loss at the lingual site and CAL were negatively affected by the angle of separation between distolingual and mesial roots in the transverse section,while they were significantly influenced by age and the angle of separation between distobuccal and mesial roots in the coronal section.Conclusions:The prevalence of PMFM-DLR in Eastern China was relatively high in our cohort.The morphological features of DLR were correlated with the periodontal status of mandibular first molars.This study provides critical information on the morphological features of DLR for improved diagnosis and treatment options of mandibular molars with DLR.
基金The authors thank all the patients and their families.We would like to acknowledge Dr.Yuchao Zhang from the Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences for his suggestions in the analysis of the proteomics data of this study.This work is supported by the National Natural Science Foundation of China(no:82073293)the National Key R&D Program of China(no:2022YFC2503700)+3 种基金the State Key Project of Natural Science Foundation of China(no:81730097)Shanghai Top Priority Research Center Project(no.2023Zz02005)the Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center(Joint Project of Emerging Frontier Technology)(no.SHDC12018116)the Clinical Research Plan of Shanghai Hospital Development Center(no.SHDC2020CR1004A).
文摘The majority of hepatocellular carcinoma(HCC)cases are diagnosed at an advanced stage.Currently,there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis(EHM).Systemic chemotherapy,such as FOLFOX4(infusions of fluorouracil,leucovorin,and oxaliplatin),has been reported for treating advanced HCC with EHM,but its effectiveness is very poor.
基金National Natural Science Foundation of China,Grant/Award Numbers:22279061,21901120,21371098The Fundamental Research Funds for the Central Universities,the Natural Science Foundation of Jiangsu Province,Grant/Award Numbers:BK20180514,BK20190503,BK20131314+1 种基金The Qing Lan Project of Jiangsu Province.Q.Z.thanks the funding support from City University of Hong Kong,Grant/Award Numbers:9380117,7005620 and 7020040Hong Kong Institute for Advanced Study,City University of Hong Kong,China。
文摘The performance of asymmetric supercapacitors(ASCs)is strongly restricted by the capacity gap between the positive and negative electrodes.To address this issue,two new electrode materials deriving from Co‐and Fe‐based metal–organic frameworks(MOFs,Co‐TAMBA‐d,and Fe‐TAMBA‐d)through a single‐step sintering method have been developed by considering the superiorities of the derivatives of MOFs including large surface areas,sufficient metal‐atom‐doping content,and extreme surface wettability to the bath solution.The as‐prepared Co‐TAMBA‐d as a positive electrode delivers typical pseudocapacitive behavior with the improvement of capacity,which is better than those of pristine MOF materials,while Fe‐TAMBA‐d as negative electrodes displays better electrochemical behavior than those of activated carbon.ASCs based on these two electrodes exhibits excellent energy density and power density of 47Wh/kg and 1658 W/kg,respectively,where this device can maintain prominent cycling stability with capacity retention after 5000 cycles being about 75%.Furthermore,the capacity can feed a series of red light‐emitting diodes,which gives solid evidence of the potential utilization.These results can afford the feasibility of isostructural MOF derivatives as promising electrodes in novel ASCs.
基金National Natural Science Foundation of China(No.82073293)Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center(Joint Project of Emerging Frontier Technology)(SHDC12018116)the Key Project of Natural Science Foundation of China(No:81730097)。
文摘Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not satisfactory.The study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to infusional fluorouracil,leucovorin,and oxaliplatin(FOLFOX4)for advanced hepatocellular carcinoma(HCC).Methods:We extracted the data of patients with advanced HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus FOLFOX4 at the Eastern Hepatobiliary Surgery Hospital,First Hospital of Jilin University,and Zhejiang Sian International Hospital and retrospectively compared for overall survival.The Cox proportional hazards model was used to calculate the hazard ratios for overall survival and disease progression after controlling for age,sex,and disease stage.Results:From July 2013 to July 2018,111 patients with HCC were included in this study.The median survival duration was 14.8 months in the ATRA plus FOLFOX4 group and 8.2 months in the FOLFOX4 only group(P<0.001).The ATRA plus FOLFOX4 group had a significantly longer median time to progression compared with the FOLFOX4 group(3.6 monthsvs.1.8 months,P<0.001).Hazard ratios for overall survival and disease progression were 0.465(95%confidence interval:0.298–0.726;P=0.001)and 0.474(0.314–0.717;P<0.001)after adjusting for potential confounders,respectively.Conclusion:ATRA plus FOLFOX4 significantly improves the overall survival and time to disease progression in patients with advanced HCC.
基金This work was funded by the National Natural Science Foundation of China(No.81801855)Young Elite Scientist Sponsorship Program by CSA(No.2018QNRC001)+1 种基金Fundamental Research Funds for the Central Universities,Chengguan District Science and Technology Project(No.2018-7-6)Lanzhou University Hospital of Stomatology Research Support Fund.
文摘Micron/nano scale topographic modification has been a significant focus of interest in current titanium(Ti)surface design.However,the influence of micron/nano structured surface on cell or bacterium behavior on the Ti implant has rarely been systematically evaluated.Moreover,except for popular microgrooves,little work has been carried out on the reaction of cells to the bionic structure.In this study,several micro-pillars mimicking cell morphology were prepared on Ti surfaces by lithography and contact printing(ICP)method,and they were further decorated with nanotube arrays by anodization technology.These surface modifications remarkablly increased the surface roughness of pristine Ti surface from 91.17 nm±5.57 nm to be more than 1000 nm,and reduced their water contact angles from 68.3°±0.7°to be 16.9°±2.4°.Then,the effects of these hierarchical micron/nano scale patterns on the behaviors of MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and P.gingivalis were studied,aiming to evaluate their performance in osseointegration,gingival epithelial sealing and antibacterial ability.Through an innovative scoring strategy,our findings showed that square micro-pillars with 6μm width and 2μm height combined with 85 nm diameter nanotubes was suitable for implant neck design,while square micro-pillars with 3μm width and 3.6μm height combined with 55 nm diameter nanotubes was the best for implant body design.Our study reveals the synergistic effect of the hierarchical micron/nano scale patterns on MG63 osteoblasts,L929 fibroblasts,SCC epithelial cells and P.gingivalis functions.It provides insight into the design of biomedical implant surfaces.
