Effect of yellow rice wine on anti-aging ability in aged mice induced by D-galactose

The present study is focused on investigation of the health protective effect of yellow rice wine(YRW)in mice and the potential underlying mechanism.Symptoms of aging were induced in mice by using Dgalactose(D-gal),and different doses of YRW(4,8,and 12 mL/kg BW)were orally administrated to D-galtreated mice for a period of six weeks.The in vivo data obtained in the present study preliminary indicated that YRW markedly increased the activity of antioxidant enzymes and reduced the concentration of MDA both in the brain and liver.Furthermore,a forced swim test showed that moderate intake of YRW(8 mL/kg BW)significantly decreased the duration of immobility,reduced the blood content of urea nitrogen and lactic acid,and increased hepatic glycogen storage.Besides,results from the Morris water maze test suggested that YRW significantly reversed cognitive impairment and also alleviated neuroapoptosis in the experimental mice by regulating the gene expressions of Bax/Bcl-2 and caspase-3.The above results indicated YRW has a potential anti-aging effect in mice and provided us certain molecular evidence for this action.

CAR-T Therapy in HIV:Pioneering Advances and Navigating Challenges

Chimeric antigen receptor T(CAR-T)cell therapy,renowned for its successes in cancer treatment,is now entering the field of human immunodeficiency virus(HIV)therapy,presenting both opportunities and challenges.With the emergence of broadly neutralizing antibodies,multi-target CARs,and T cell receptor-like antibodies aimed at increasing specificity in targeting HIV reservoirs,CAR-T therapy is synergizing with other cutting-edge treatments,including gene-editing technologies,therapeutic vaccines,and latency-reversing agents,in pursuit of a potential functional cure.In this review,we delve into the role of CAR-T therapy in HIV treatment,highlighting its potential to overcome clinical obstacles.We discuss advancements in targeting strategies within CAR constructs and the intricate regulation of T cell proliferation and chemotaxis.Moreover,we explore the use of diverse immune cells,such as gamma-delta T cells and natural killer cells.We review advanced biotechnologies,manufacturing innovations,viral mechanisms,and immune microenvironments.We also discuss the current research landscape and potential future applications of CAR-T therapy against HIV,which remains a critical global health challenge.