AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol self-administra-tion.METHODS:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ...AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol self-administra-tion.METHODS:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ethanol(10%v/v)self-administration in male Wistar rats that were madeethanol-dependent by chronic(14 d)exposure toethanol vapor-chambers or exposed to air in identicalvapor chambers.RESULTS:Dependent animalsresponded more for ethanol than did air controlnondependent tats.The acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.However,operant responses for food were not afected by the administration of SR141716A.CONCLU.SION:These results further support that cannabinoid CB_(1) receptor blockade may have a potential utility for the treatment of alcobolism.展开更多
基金DGICYT PM 96/0047,Comunidad de Madrid and Plan Nacional Sobre Drogas(MN,FRF)National Institutes of Health grants AA 06420AA 08459 from the National Institute on Alcohol Abuse and Alcoholism(GFK and AJR)
文摘AIM:To study the potential role of dependence statuson CB_(1)-mediated blockade of ethanol self-administra-tion.METHODS:We examined the effects of thecannabinoid antagonist SR141716A(0,0.03,0.3,and 3 mg/kg)on pperant ethanol(10%v/v)self-administration in male Wistar rats that were madeethanol-dependent by chronic(14 d)exposure toethanol vapor-chambers or exposed to air in identicalvapor chambers.RESULTS:Dependent animalsresponded more for ethanol than did air controlnondependent tats.The acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.However,operant responses for food were not afected by the administration of SR141716A.CONCLU.SION:These results further support that cannabinoid CB_(1) receptor blockade may have a potential utility for the treatment of alcobolism.
