电缆作为输电线路重要一环,其运行状态对电力系统影响重大,当电缆结构发生异常时,由于电力电缆敷设环境较为复杂,难以对不均匀结构的电缆进行详细分析。该文以数据驱动的信息融合处理技术为基础,提出了一种基于卷积神经网络(convolution...电缆作为输电线路重要一环,其运行状态对电力系统影响重大,当电缆结构发生异常时,由于电力电缆敷设环境较为复杂,难以对不均匀结构的电缆进行详细分析。该文以数据驱动的信息融合处理技术为基础,提出了一种基于卷积神经网络(convolutional neural network,CNN)和长短期记忆网络(long short term memory,LSTM)混合模型的电力电缆故障诊断方法,将CNN强大的局部特征提取能力和LSTM处理长序列的方法相结合,有效解决了因电缆参数变化致使原始数据多源性和异构性的问题。使用CNN-LSTM(convolutional neural network-long short term memory)对9种不同类型的电缆状态进行分类,平均识别率为95.9%。所提方法与传统的反向传播神经网络(back propagation neural network,BPNN)、LSTM等方式进行对比,结果表明,提出的电缆故障诊断方法的检测效果优于传统方法,具有更高的可靠性和稳定性。展开更多
Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and FGF21.Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor a...Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and FGF21.Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin(Oln).Fap is also expressed in synovial fibroblasts and positively correlated with the severity of rheumatoid arthritis(RA).However,whether Fap plays a critical role in osteoarthritis(OA)remains poorly understood.Here,we found that Fap is significantly elevated in osteoarthritic synovium,while the genetic deletion or pharmacological inhibition of Fap significantly ameliorated posttraumatic OA in mice.Mechanistically,we found that Fap degrades denatured type II collagen(Col II)and Mmp13-cleaved native Col II.Intra-articular injection of r Fap significantly accelerated Col II degradation and OA progression.In contrast,Oln is expressed in the superficial layer of articular cartilage and is significantly downregulated in OA.Genetic deletion of Oln significantly exacerbated OA progression,which was partially rescued by Fap deletion or inhibition.Intra-articular injection of r Oln significantly ameliorated OA progression.Taken together,these findings identify Fap as a critical pathogenic factor in OA that could be targeted by both synthetic and endogenous inhibitors to ameliorate articular cartilage degradation.展开更多
Many problems in science and engineering require solving large consistent linear systems. This paper presents a relaxed greedy block Kaczmarz method (RGBK) and an accelerated greedy block Kaczmarz method (AGBK) for so...Many problems in science and engineering require solving large consistent linear systems. This paper presents a relaxed greedy block Kaczmarz method (RGBK) and an accelerated greedy block Kaczmarz method (AGBK) for solving large-size consistent linear systems. The RGBK algorithm extends the greedy block Kaczmarz algorithm (GBK) presented by Niu and Zheng in <a href="#ref1">[1]</a> by introducing a relaxation parameter to the iteration formulation of GBK, and the AGBK algorithm uses different iterative update rules to minimize the running time. The convergence of the RGBK is proved and a method to determine an optimal parameter is provided. Several examples are presented to show the effectiveness of the proposed methods for overdetermined and underdetermined consistent linear systems with dense and sparse coefficient matrix.展开更多
This paper presents a geometric Gaussian Kaczmarz (GGK) method for solving the large-scaled consistent linear systems of equation. The GGK method improves the geometric probability randomized Kaczmarz method in <a ...This paper presents a geometric Gaussian Kaczmarz (GGK) method for solving the large-scaled consistent linear systems of equation. The GGK method improves the geometric probability randomized Kaczmarz method in <a href="#ref1">[1]</a> by introducing a new block set strategy and the iteration process. The GGK is proved to be of linear convergence. Several numerical examples show the efficiency and effectiveness of the GGK method.展开更多
目的评价宫腔镜检查在首次体外受精-胚胎移植(IVF-ET)患者中的应用价值。方法检索PubMed、Medline、ProQuest Medical Library、中国知网(CNKI)、万方等数据库,收集2000年1月至2017年12月发表的论文,对宫腔镜干预组和对照组的临床妊娠...目的评价宫腔镜检查在首次体外受精-胚胎移植(IVF-ET)患者中的应用价值。方法检索PubMed、Medline、ProQuest Medical Library、中国知网(CNKI)、万方等数据库,收集2000年1月至2017年12月发表的论文,对宫腔镜干预组和对照组的临床妊娠率进行数据提取,按Cochrane系统评价方法提取有效数据,采用RevMan 5.1软件进行Meta分析。结果宫腔镜干预组临床妊娠率显著高于对照组[RR=1.35,95%CI(1.17,1.56),P<0.000 1]。宫腔镜异常组临床妊娠率与正常组无显著差异[RR=0.94,95%CI(0.83,1.06),P=0.280]。结论对于首次IVF-ET术前患者,宫腔镜干预有助于发现阴道B超遗漏的宫腔微小病变,改善内膜容受性,从而提高临床妊娠率。展开更多
文摘电缆作为输电线路重要一环,其运行状态对电力系统影响重大,当电缆结构发生异常时,由于电力电缆敷设环境较为复杂,难以对不均匀结构的电缆进行详细分析。该文以数据驱动的信息融合处理技术为基础,提出了一种基于卷积神经网络(convolutional neural network,CNN)和长短期记忆网络(long short term memory,LSTM)混合模型的电力电缆故障诊断方法,将CNN强大的局部特征提取能力和LSTM处理长序列的方法相结合,有效解决了因电缆参数变化致使原始数据多源性和异构性的问题。使用CNN-LSTM(convolutional neural network-long short term memory)对9种不同类型的电缆状态进行分类,平均识别率为95.9%。所提方法与传统的反向传播神经网络(back propagation neural network,BPNN)、LSTM等方式进行对比,结果表明,提出的电缆故障诊断方法的检测效果优于传统方法,具有更高的可靠性和稳定性。
基金National Key R&D Program of China(2022YFA1103200,2017YFA0106400,2021YFA1100900)Ministry of Science and Technology of China(2020YFC2002804)+3 种基金National Natural Science Foundation of China(91749124,81772389,82070108)Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone(ZJ2018-ZD-004)Fundamental Research Funds for the Central Universities(22120190149 and kx0200020173386)Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai。
文摘Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and FGF21.Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin(Oln).Fap is also expressed in synovial fibroblasts and positively correlated with the severity of rheumatoid arthritis(RA).However,whether Fap plays a critical role in osteoarthritis(OA)remains poorly understood.Here,we found that Fap is significantly elevated in osteoarthritic synovium,while the genetic deletion or pharmacological inhibition of Fap significantly ameliorated posttraumatic OA in mice.Mechanistically,we found that Fap degrades denatured type II collagen(Col II)and Mmp13-cleaved native Col II.Intra-articular injection of r Fap significantly accelerated Col II degradation and OA progression.In contrast,Oln is expressed in the superficial layer of articular cartilage and is significantly downregulated in OA.Genetic deletion of Oln significantly exacerbated OA progression,which was partially rescued by Fap deletion or inhibition.Intra-articular injection of r Oln significantly ameliorated OA progression.Taken together,these findings identify Fap as a critical pathogenic factor in OA that could be targeted by both synthetic and endogenous inhibitors to ameliorate articular cartilage degradation.
文摘Many problems in science and engineering require solving large consistent linear systems. This paper presents a relaxed greedy block Kaczmarz method (RGBK) and an accelerated greedy block Kaczmarz method (AGBK) for solving large-size consistent linear systems. The RGBK algorithm extends the greedy block Kaczmarz algorithm (GBK) presented by Niu and Zheng in <a href="#ref1">[1]</a> by introducing a relaxation parameter to the iteration formulation of GBK, and the AGBK algorithm uses different iterative update rules to minimize the running time. The convergence of the RGBK is proved and a method to determine an optimal parameter is provided. Several examples are presented to show the effectiveness of the proposed methods for overdetermined and underdetermined consistent linear systems with dense and sparse coefficient matrix.
文摘This paper presents a geometric Gaussian Kaczmarz (GGK) method for solving the large-scaled consistent linear systems of equation. The GGK method improves the geometric probability randomized Kaczmarz method in <a href="#ref1">[1]</a> by introducing a new block set strategy and the iteration process. The GGK is proved to be of linear convergence. Several numerical examples show the efficiency and effectiveness of the GGK method.
文摘目的评价宫腔镜检查在首次体外受精-胚胎移植(IVF-ET)患者中的应用价值。方法检索PubMed、Medline、ProQuest Medical Library、中国知网(CNKI)、万方等数据库,收集2000年1月至2017年12月发表的论文,对宫腔镜干预组和对照组的临床妊娠率进行数据提取,按Cochrane系统评价方法提取有效数据,采用RevMan 5.1软件进行Meta分析。结果宫腔镜干预组临床妊娠率显著高于对照组[RR=1.35,95%CI(1.17,1.56),P<0.000 1]。宫腔镜异常组临床妊娠率与正常组无显著差异[RR=0.94,95%CI(0.83,1.06),P=0.280]。结论对于首次IVF-ET术前患者,宫腔镜干预有助于发现阴道B超遗漏的宫腔微小病变,改善内膜容受性,从而提高临床妊娠率。
