利妥昔单抗对B细胞非霍奇金淋巴瘤患者体液免疫的影响

目的探讨利妥昔单抗(RTX)治疗B细胞非霍奇金淋巴瘤(B-NHL)后对患者体液免疫的影响。方法回顾性分析安徽医科大学第二附属医院诊治的86例B-NHL患者,按治疗方案不同分为观察组和对照组,其中使用RTX联合环磷酰胺、多柔比星、长春新碱、泼尼松(R-CHOP)方案治疗为观察组,CHOP方案治疗为对照组,比较两组患者治疗前后外周血中CD20^+正常B淋巴细胞比例、血清中免疫球蛋白及其主要亚型的变化以及治疗过程中感染发生情况。结果①4个疗程后,观察组仅14%(9/64)的患者外周血中检测出CD20^+正常B淋巴细胞,而对照组100%(16/16)患者外周血中CD20^+正常B淋巴细胞均可测出。②观察组患者化疗后外周血免疫球蛋白及其主要亚型IgG、IgA及IgM水平降低(P <0.05),而对照组治疗前后比较差异无统计学意义(P>0.05)。其次,观察组4个疗程后低免疫球蛋白血症发生率高于对照组(P<0.05)。③治疗过程中,观察组患者感染发生率为45.71%,感染事件分级以1、2级为主,占81.25%。4个疗程后,与免疫球蛋白正常的患者比较,出现低免疫球蛋白的患者更易发感染(P<0.05)。结论 RTX治疗B-NHL后会损伤患者体液免疫,同时增加感染事件发生率。因此,化疗期间应动态检测患者血清中免疫球蛋白及其主要亚型的水平,避免感染的发生。

An Improved Chirplet Transform and Its Application for Harmonics Detection

The chirplet transform is the generalization form of fast Fourier transform , short-time Fourier transform, and wavelet transform. It has the most flexible time frequency window and successfully used in practices. However, the chirplet transform has not inherent inverse transform, and can not overcome the signal reconstructing problem. In this paper, we proposed the improved chirplet transform (ICT) and constructed the inverse ICT. Finally, by simulating the harmonic voltages, The power of the improved chirplet transform are illustrated for harmonic detection. The contours clearly showed the harmonic occurrence time and harmonic duration.