The synaptonemal complex(SC)is a meiosis-specific proteinaceous macromolecular structure that assembles between paired homologous chromosomes during meiosis in various eukaryotes.The SC has a highly conserved ultrastr...The synaptonemal complex(SC)is a meiosis-specific proteinaceous macromolecular structure that assembles between paired homologous chromosomes during meiosis in various eukaryotes.The SC has a highly conserved ultrastructure and plays critical roles in controlling multiple steps in meiotic recombination and crossover formation,ensuring accurate meiotic chromosome segregation.Recent studies in different organisms,facilitated by advances in super-resolution microscopy,have provided insights into the macromolecular structure of the SC,including the internal organization of the meiotic chromosome axis and SC central region,the regulatory pathways that control SC assembly and dynamics,and the biological functions exerted by the SC and its substructures.This review summarizes recent discoveries about how the SC is organized and regulated that help to explain the biological functions associated with this meiosis-specific structure.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China(No.31871360,No.32022018,and No.31701176 to JMG)。
文摘The synaptonemal complex(SC)is a meiosis-specific proteinaceous macromolecular structure that assembles between paired homologous chromosomes during meiosis in various eukaryotes.The SC has a highly conserved ultrastructure and plays critical roles in controlling multiple steps in meiotic recombination and crossover formation,ensuring accurate meiotic chromosome segregation.Recent studies in different organisms,facilitated by advances in super-resolution microscopy,have provided insights into the macromolecular structure of the SC,including the internal organization of the meiotic chromosome axis and SC central region,the regulatory pathways that control SC assembly and dynamics,and the biological functions exerted by the SC and its substructures.This review summarizes recent discoveries about how the SC is organized and regulated that help to explain the biological functions associated with this meiosis-specific structure.
