期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Papillary fibroblast-recruiting injectable self-healing multifunctional hydrogels for wound regeneration 被引量:1
1
作者 Yueyue Li Weifeng Zhong +12 位作者 Junjie Wu yuan Jia Zhonghua Chen Kaiwen Zhang Danyang Guo Yifei Fu Mengnan Chen Weiwei Chen Fan Tian Xia Li Hongji Zhang Xiaojin Zhou feng-lai yuan 《Nano Research》 SCIE EI CSCD 2023年第7期9792-9803,共12页
The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound healing.Dermal fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to injur... The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound healing.Dermal fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to injury.Papillary fibroblasts play central regulatory roles in the regeneration of skin appendages during wound healing.Inspired by the phenomenon where bait for grass carp can attract grouped grass carps to a fishing spot soon,“Grass Carp Fishing”multifunctional hydrogels,that is,codelivery of an antibody of leucine-rich repeats and immunoglobulin-like domains 1(Lrig1)on the surface of papillary fibroblasts and insulinlike growth factor 1(IGF1)with recruitment function,can recruit papillary fibroblasts.In the experiments,carboxymethyl chitosan showed positive effects in promoting cell proliferation and neovascularization,while dopamine-grafted gelatin was effective in stabilizing the structure and prolonging the degradation time.The sustained release of Lrig1 antibodies and IGF1 from injectable self-healing multifunctional hydrogels persistently accelerated the migration and proliferation of Lrig1+fibroblasts.The in vivo results from a full-thickness cutaneous wound model showed that injectable self-healing multifunctional hydrogel accelerated wound healing and skin regeneration through the recruitment of Lrig1+papillary fibroblasts in wound tissue.Our findings reveal an injectable self-healing multifunctional hydrogel for regeneration,a promising approach to promoting skin wound healing. 展开更多
关键词 wound healing REGENERATION papillary fibroblasts recruitment
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部