The therapeutic efficacy and safety of Gongxuening capsule in dysfunctional uterine bleeding:a systematic review and meta-analysis

Background:Gongxuening capsule is a Chinese patent medicine for treating the dysfunctional uterine bleeding.We report a meta-analysis of the combination efficacy between conventional medicines with Chinese patent drug Gongxuening in the treatment of dysfunctional uterine bleeding.Materials and methods:Seven databases were used to retrieve the relevant research of Chinese patent drug Gongxuening treatment for dysfunctional uterine bleeding from the databases establishment to 2020.The data were extracted independently by 2 researchers according to the described selection research.The meta-analysis was performed using RevMan5.3 software.Results:This study included 23 randomized trials,with a total of 1,836 dysfunctional uterine bleeding patients.Chinese patent drug Gongxuening could significantly improve the effective rate,and reduce endometrial thickness,control bleeding time,complete hemostasis time and sex hormone level,and no serious adverse events.Based on sensitivity analysis and subgroup analysis,the heterogeneity sources of endometrial thickness,complete hemostasis time and sex hormone level were found.In follicle stimulating hormone and luteinizing hormone,there was no significant difference between the two groups when Chinese patent drug Gongxuening combined with desogestrel ethinylestradiol.Conclusion:Conventional medicines combined with Chinese patent drug Gongxuening can make patients with dysfunctional uterine bleeding achieve better effective rate,and no serious adverse events occurred.

Dynamical Behavior of SEIR-SVS Epidemic Models with Nonlinear Incidence and Vaccination

For some infectious diseases such as mumps,HBV,there is evidence showing that vaccinated individuals always lose their immunity at different rates depending on the inoculation time.In this paper,we propose an age-structured epidemic model using a step function to describe the rate at which vaccinated individuals lose immunity and reduce the age-structured epidemic model to the delay differential model.For the age-structured model,we consider the positivity,boundedness,and compactness of the semiflow and study global stability of equilibria by constructing appropriate Lyapunov functionals.Moreover,for the reduced delay differential equation model,we study the existence of the endemic equilibrium and prove the global stability of equilibria.Finally,some numerical simulations are provided to support our theoretical results and a brief discussion is given.

Global stability of an epidemic model for HIV-TB co-infection with infection-age

A nonlinear mathematical HIV TB model with infection-age is proposed in this paper. The basic reproduction numbers according to HIV and TB are respectively determined whether one of the diseases dies out or persists. The local and global stability of the disease-free and dominated equilibria are discussed by employing integral semigroup theory and Lyapunov functionals. The persistence of the system is also obtained by the persistence theories of the systems. The simulation illustrates the theoretical results.