Research progress on markers of urine tubular damage in idiopathic membranous nephropathy

Idiopathic membranous nephropathy is a common primary glomerular disease.Recently,it has been found that the progression and prognosis of glomerular diseases are not only related to the glomeruli itself,but also to the severity of renal tubular injury.Although blood creatinine and urinary protein are recognized biomarkers,they appear late,are insensitive,lack specificity,and are difficult to respond to IMN conditions in a timely and accurate manner.Markers such as N-acetyl-β-D-glucosaminidase,kidney injury molecule 1,neutrophil gelatinase-associated lipoprotein in urine can dynamically reflect the progress of kidney injury in the early stage,and are detected as noninvasive,so It has been applied in IMN,but such research is lacking,and the scope needs to be further expanded and discussed in depth.

The role and advantage of traditional Chinese medicine in the prevention and treatment of COVID-19

The global coronavirus disease 2019(COVID-19)pandemic has had a massive impact on global social and economic development and human health.By combining traditional Chinese medicine(TCM)with modern medicine,the Chinese government has protected public health by supporting all phases of COVID-19 prevention and treatment,including community prevention,clinical treatment,control of disease progression,and promotion of recovery.Modern medicine focuses on viruses,while TCM focuses on differential diagnosis of patterns associated with viral infection of the body and recommends the use of TCM decoctions for differential treatment.This differential diagnosis and treatment approach,with its profoundly empirical nature and holistic view,endows TCM with an accessibility advantage and high application value for dealing with COVID-19.Here,we summarize the advantage of and evidence for TCM use in COVID-19 prevention and treatment to draw attention to the scientific value and accessibility advantage of TCM and to promote the use of TCM in response to public health emergencies.

基于网状Meta分析的针刺相关疗法治疗心力衰竭疗效评价(英文)

目的:采用网状Meta分析的方法评价针刺及其相关技术补充治疗心力衰竭的疗效。方法:检索中国知网、万方、中国生物医学数据库、PubMed、Cochrane Central及Embase数据库,检索时限为建库至2017年12月。收集已发表的在常规治疗基础上联用针刺及其相关技术治疗心力衰竭的随机对照试验,主要结局指标为纽约心功能分级及射血分数。运用Cochrane协作网推荐的偏倚风险评价工具对纳入研究进行质量评价,运用WinBUGS1.4.3和STATA 13.0软件进行数据处理及作图。结果:检索筛选后纳入符合要求的研究26篇,合计2116名患者,包含5种干预措施(针刺、艾灸、穴位贴敷、穴位注射、温针灸)。Meta分析结果显示:相比常规治疗,联合穴位按压(OR:3.28,95%CI[2.26,4.76]),针刺(OR:2.78, 95%CI[1.21, 6.41]),穴位注射(OR:3.33, 95%CI[1.85, 6.00])以及艾灸(OR:2.51, 95%CI[1.02, 6.21])均能改善患者心功能分级;联合穴位按压(MD:3.57, 95%CI[1.45, 5.70]),针刺(MD:7.75, 95%CI[2.33, 13.17]),穴位注射(MD:4.81,95%CI[2.99, 6.63])以及艾灸(MD:6.99, 95%CI[3.62, 10.36])均能提高患者射血分数。网状Meta分析结果显示:联合穴位注射对改善心功能分级效果相对最佳(SUCRA=70.0%),联合针刺对提高射血分数效果相对最佳(SUCRA=90.4%)。结论:在常规治疗基础上联合针刺及其相关技术对改善患者心功能分级、提高射血分数具有一定疗效。穴位注射对改善心功能优势较明显,针刺对提高射血分数优势较明显。但由于纳入研究数目较少、方法学质量较低,结论需进一步验证。本研究已在国际系统评价注册平台PROSPERO注册,注册号:CRD42018087700。