目的探讨细胞因子信号传导抑制蛋白2(SOCS2)和SOCS5在儿童过敏性紫癜(HSP)中的表达及其意义。方法应用逆转录聚合酶链反应检测HSP患儿(36例)和正常健康对照儿童(17例)外周血单个核细胞中SOCS2和SOCS5 m RNA表达水平。结果 HSP患儿SOCS2...目的探讨细胞因子信号传导抑制蛋白2(SOCS2)和SOCS5在儿童过敏性紫癜(HSP)中的表达及其意义。方法应用逆转录聚合酶链反应检测HSP患儿(36例)和正常健康对照儿童(17例)外周血单个核细胞中SOCS2和SOCS5 m RNA表达水平。结果 HSP患儿SOCS2和SOCS5 m RNA表达水平高于对照儿童(P<0.05)。混合型HSP患儿SOCS2和SOCS5 m RNA表达水平较单纯型患儿升高(P<0.05)。HSP患儿SOCS2和SOCS5 m RNA表达水平无性别差异(P>0.05)。结论 SOCS2、SOCS5可能参与儿童HSP的发病。展开更多
Background： Hypotension induced by combined spinal epidural anesthesia in parturient with hypertensive disorders of pregnancy （HDP） can easily compromise blood supply to vital organs including uteroplacental perfus...Background： Hypotension induced by combined spinal epidural anesthesia in parturient with hypertensive disorders of pregnancy （HDP） can easily compromise blood supply to vital organs including uteroplacental perfusion and result in fetal distress. The aim of this study was to investigate whether the goal-directed fluid therapy （GDFT） with LiDCOrapid system can improve well-being of both HDP parturient and their babies. Methods： Fifty-two stable HDP parturient scheduled for elective cesarean delivery were recruited. After loading with 10 ml/kg lactated Ringer＇s solution （LR）, parturient were randomized to the GDFT and control group. In the GDFT group, individualized fluid therapy was guided by increase in stroke volume （ASV） provided via LiDCO rapid system. The control group received the routine fluid therapy. The primary endpoints included maternal hypotension and the doses of vasopressors administered prior to fetal delivery. The secondary endpoints included umbilical blood gas abnormalities and neonatal adverse events. Results： The severity of HDP was similar between two groups. The total LR infusion （P 〈 0.01） and urine output （P 〈 0.05） were higher in the GDFT group than in the control group. Following twice fluid challenge tests, the systolic blood pressure, mean blood pressure, cardiac output and SV in the GDFT group were significantly higher, and the heart rate was lower than in the control group. The incidence of maternal hypotension and doses of phenylephrine used prior to fetal delivery were significantly higher in the control group than in the GDFT group （P 〈 0.01）. There were no differences in the Apgar scores between two groups. In the control group, the mean values of pH in umbilical artery/vein were remarkably decreased （P 〈 0.05）, and the incidences of neonatal hypercapnia and hypoxemia were statistically increased （P 〈 0.05） than in the GDFT group. Conclusions： Dynamic responsiveness guided fluid therapy with the LiDCOrapid system may provide potential benefits to stable HDP parturient and their babies.展开更多
We propose a contraction transformation algorithm to plan a complete coverage trajectory for a mobile robot to ac-complish specific types of missions based on the Arnold dynamical system. First, we construct a chaotic...We propose a contraction transformation algorithm to plan a complete coverage trajectory for a mobile robot to ac-complish specific types of missions based on the Arnold dynamical system. First, we construct a chaotic mobile robot by com-bining the variable z of the Arnold equation and the kinematic equation of the robot. Second, we construct the candidate sets including the initial points with a relatively high coverage rate of the constructed mobile robot. Then the trajectory is contracted to the current position of the robot based on the designed contraction transformation strategy, to form a continuous complete cov-erage trajectory to execute the specific types of missions. Compared with the traditional method, the designed algorithm requires no obstacle avoidance to the boundary of the given workplace, possesses a high coverage rate, and keeps the chaotic characteristics of the produced coverage trajectory relatively unchanged, which enables the robot to accomplish special missions with features of completeness, randomness, or unpredictability.展开更多
文摘目的探讨细胞因子信号传导抑制蛋白2(SOCS2)和SOCS5在儿童过敏性紫癜(HSP)中的表达及其意义。方法应用逆转录聚合酶链反应检测HSP患儿(36例)和正常健康对照儿童(17例)外周血单个核细胞中SOCS2和SOCS5 m RNA表达水平。结果 HSP患儿SOCS2和SOCS5 m RNA表达水平高于对照儿童(P<0.05)。混合型HSP患儿SOCS2和SOCS5 m RNA表达水平较单纯型患儿升高(P<0.05)。HSP患儿SOCS2和SOCS5 m RNA表达水平无性别差异(P>0.05)。结论 SOCS2、SOCS5可能参与儿童HSP的发病。
文摘Background： Hypotension induced by combined spinal epidural anesthesia in parturient with hypertensive disorders of pregnancy （HDP） can easily compromise blood supply to vital organs including uteroplacental perfusion and result in fetal distress. The aim of this study was to investigate whether the goal-directed fluid therapy （GDFT） with LiDCOrapid system can improve well-being of both HDP parturient and their babies. Methods： Fifty-two stable HDP parturient scheduled for elective cesarean delivery were recruited. After loading with 10 ml/kg lactated Ringer＇s solution （LR）, parturient were randomized to the GDFT and control group. In the GDFT group, individualized fluid therapy was guided by increase in stroke volume （ASV） provided via LiDCO rapid system. The control group received the routine fluid therapy. The primary endpoints included maternal hypotension and the doses of vasopressors administered prior to fetal delivery. The secondary endpoints included umbilical blood gas abnormalities and neonatal adverse events. Results： The severity of HDP was similar between two groups. The total LR infusion （P 〈 0.01） and urine output （P 〈 0.05） were higher in the GDFT group than in the control group. Following twice fluid challenge tests, the systolic blood pressure, mean blood pressure, cardiac output and SV in the GDFT group were significantly higher, and the heart rate was lower than in the control group. The incidence of maternal hypotension and doses of phenylephrine used prior to fetal delivery were significantly higher in the control group than in the GDFT group （P 〈 0.01）. There were no differences in the Apgar scores between two groups. In the control group, the mean values of pH in umbilical artery/vein were remarkably decreased （P 〈 0.05）, and the incidences of neonatal hypercapnia and hypoxemia were statistically increased （P 〈 0.05） than in the GDFT group. Conclusions： Dynamic responsiveness guided fluid therapy with the LiDCOrapid system may provide potential benefits to stable HDP parturient and their babies.
基金Project supported by thc National Natural Science Foundation of China （Nos. 61473179, 61573213, and 61233014）, the Natural Sci- ence Foundation of Shandong Province, China （Nos. ZR2014FM007 and ZR2015CM016）, and the Key Research and Development Project of Shandong Province, China （No. 2016GGX101027）
基金Project supported by the National Natural Science Foundation of China(Nos.61473179,61602280,and 61573213)the Natural Science Foundation of Shandong Province,China(Nos.ZR2017MF047,ZR2015CM016,and ZR2014FM007)the Shandong University of Technology&Zibo City Integration Development Project,China(No.2018ZBXC295)。
文摘We propose a contraction transformation algorithm to plan a complete coverage trajectory for a mobile robot to ac-complish specific types of missions based on the Arnold dynamical system. First, we construct a chaotic mobile robot by com-bining the variable z of the Arnold equation and the kinematic equation of the robot. Second, we construct the candidate sets including the initial points with a relatively high coverage rate of the constructed mobile robot. Then the trajectory is contracted to the current position of the robot based on the designed contraction transformation strategy, to form a continuous complete cov-erage trajectory to execute the specific types of missions. Compared with the traditional method, the designed algorithm requires no obstacle avoidance to the boundary of the given workplace, possesses a high coverage rate, and keeps the chaotic characteristics of the produced coverage trajectory relatively unchanged, which enables the robot to accomplish special missions with features of completeness, randomness, or unpredictability.
