Skin aging and wound healing have always been significant topics in the skin field.Hyaluronic acid(HA),a natural glycosaminoglycan(GAG)presenting in the extracellular matrix(ECM),is extensively applied in the fields o...Skin aging and wound healing have always been significant topics in the skin field.Hyaluronic acid(HA),a natural glycosaminoglycan(GAG)presenting in the extracellular matrix(ECM),is extensively applied in the fields of anti-aging therapeutics and wound repair due to its unique physicochemical and biological properties.HA is indispensable in the regulation of diverse biological processes such as cellular proliferation,differentiation,migration,signaling,inflammatory responses,angiogenesis,and tissue regeneration.Consequently,HA-based formulations,including creams,gels,serums,and dermal fillers,are instrumental in combating wrinkles,enhancing skin hydration,correcting tear trough deformity,and restoring facial volume.Additionally,the inherent biocompatibility and high biodegradability of HA facilitates its chemical modification,rendering it an ideal material for wound healing and tissue regeneration.This review summarizes the recent advances and applications of the molecular mechanisms of HA and its derivatives in the field of anti-aging and wound healing;and discusses the prospects and challenges of HA-based compounds in tissue repair and skin regeneration.展开更多
To the Editor:Acne vulgaris is a chronic,inflammatory,and disfiguring skin disease with lesions,post-inflammatory hyperpigmentation,and scarring.Chemical peeling is a simple and well-tolerated procedure for mild-to-mo...To the Editor:Acne vulgaris is a chronic,inflammatory,and disfiguring skin disease with lesions,post-inflammatory hyperpigmentation,and scarring.Chemical peeling is a simple and well-tolerated procedure for mild-to-moderate acne.Glycolic acid(GA)is water-soluble and has the smallest molecular weight among all the alpha-hydroxy acids.High-concentration GA(20%–70%),applied at 2 to 4-week intervals in the hospital or cosmetology clinic,have proved effective for acne.[1]Low-concentration GA(10%)is safe and convenient,and can be used at home.[2]Up to now,differences in efficiency between low and high concentrations of GA for acne vulgaris have not been reported.This study compared the efficacy and safety of 5%GA complex and 20%GA for acne patients,to guide GA selection at different concentrations.展开更多
基金supported by the National Natural Science Foundation of China[grant number:82273555]the Beijing Municipal Nature Science Foundation[grant number:L234068].
文摘Skin aging and wound healing have always been significant topics in the skin field.Hyaluronic acid(HA),a natural glycosaminoglycan(GAG)presenting in the extracellular matrix(ECM),is extensively applied in the fields of anti-aging therapeutics and wound repair due to its unique physicochemical and biological properties.HA is indispensable in the regulation of diverse biological processes such as cellular proliferation,differentiation,migration,signaling,inflammatory responses,angiogenesis,and tissue regeneration.Consequently,HA-based formulations,including creams,gels,serums,and dermal fillers,are instrumental in combating wrinkles,enhancing skin hydration,correcting tear trough deformity,and restoring facial volume.Additionally,the inherent biocompatibility and high biodegradability of HA facilitates its chemical modification,rendering it an ideal material for wound healing and tissue regeneration.This review summarizes the recent advances and applications of the molecular mechanisms of HA and its derivatives in the field of anti-aging and wound healing;and discusses the prospects and challenges of HA-based compounds in tissue repair and skin regeneration.
基金National Natural Science Foundation of China(No. 82273555)Beijing Natural Science Foundation(No. 722240)
文摘To the Editor:Acne vulgaris is a chronic,inflammatory,and disfiguring skin disease with lesions,post-inflammatory hyperpigmentation,and scarring.Chemical peeling is a simple and well-tolerated procedure for mild-to-moderate acne.Glycolic acid(GA)is water-soluble and has the smallest molecular weight among all the alpha-hydroxy acids.High-concentration GA(20%–70%),applied at 2 to 4-week intervals in the hospital or cosmetology clinic,have proved effective for acne.[1]Low-concentration GA(10%)is safe and convenient,and can be used at home.[2]Up to now,differences in efficiency between low and high concentrations of GA for acne vulgaris have not been reported.This study compared the efficacy and safety of 5%GA complex and 20%GA for acne patients,to guide GA selection at different concentrations.
