Perilla oil and exercise decrease expressions of tumor necrosis factor-α,plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia

OBJECTIVE:To verify the effects of perilla oil on the regulation of blood lipid levels in patients with hyperlipidemia.METHODS:Blood was taken from patients prior to and 8 weeks following treatment with perilla oil.Different ways to test for indexes which correlate to hyperlipidemia were performed.Some indexes,which correlate with inflammation and injury to endothelial cells,were tested using enzyme linked immunosorbent assays.RESULTS:Serum lipid levels [triglyceride(TG),total cholesterol(TC),and low-density lipoprotein-cholesterol(LDL-C)] changed significantly after 56 days of treatment.Differences were noted as early as 28 days after treatment began(P<0.05).Treatment with perilla oil showed statistically significant recovery levels of high-density lipoprotein-cholesterol(HDL-C) after 28 and 56 days of treatment.Plasma lipids levels were significantly lower after 56 days of treatment(P<0.05).Perilla oil reduced blood lipid levels in patients,and the regulation of cell signaling factor levels had no adverse effects on patients' liver or kidney function,or blood routine examinations.CONCLUSION:Perilla oil treatment is safe in clinical use,can regulate blood lipid levels and protects the function of endothelial cells.

Unstabilized and uncritical self-amalgamation along essential subsurfaces

Suppose V ∪S W is a strongly irreducible Heegaard splitting of a compact connected orientable 3-manifold M and F1 and F2 are pairwise disjoint homeomorphic essential subsurfaces in ?V. In this paper,we give a sufficient condition such that the self-amalgamation of V ∪S W along F1 and F2 is unstabilized and uncritical.

A Theory of Orbit Braids

In this paper,the authors systematically discuss orbit braids in M×I with regards to orbit configuration space FG(M,n),where M is a connected topological manifold of dimension at least 2 with an effective action of a finite group G.These orbit braids form a group,named orbit braid group,which enriches the theory of ordinary braids.The authors analyze the substantial relations among various braid groups associated to those configuration spaces FG(M,n),F(M/G,n)and F(M,n).They also consider the presentations of orbit braid groups in terms of orbit braids as generators by choosing M=C with typical actions of Zpand(Z_(2))^(2).

Qiguiyishen decoction reduced the accumulation of extracellular matrix in the kidneys of rats with adriamycin-induced nephropathy

OBJECTIVE： To investigate the effect of Qiguiyish- en decoction （QGYS） on the severity of nephropa- thy. METHODS： Twenty-four rats were randomly divid- ed into four groups （ Ⅰ,Ⅱ,Ⅲ, IV） according to the random number table. Group I as control group did not establish nephropathy model. Groups Ⅱ, Ⅲ, and IV were intravenously administered Adria- mycin （7.5 mg/kg） through the tail vein to establish nephropathy model. QGYS was prepared with the extracts of Huangqi （RadixAstragali Mongolici）, Dan- ggui （Radix Angelicae Sinensis）, Niuxi （Radix Achyran-this Bidentatae）, and Chuanxiong （Rhizoma Chuanx- iong）. Group IV was administered QGYS （2 mL. kg^-1· d^-1）, groupⅢ was administered benazepril （10 mL. kg^-1·d^-1）, and group ⅠⅡ was administered water （2 mL. kg·^-1. d^-1） once daily for eight weeks. RESULTS： QGYS reduced the excretion of urinary protein and N-acetyH3-D-glucosaminidase and alle- viated the accumulation of extracellular matrix （ECM） in renal tissue. Additionally, QGYS effectively regulated the levels of transforming growth factor, tissue inhibitor of matrix metalloproteinase, and matrix metalloproteinases in the kidney of the rats. CONCLUSION-＂ QGYS may reduce the accumulation of ECM in the kidneys of rats with Adriamycin-in- duced nephropathy.

A necessary and sufficient condition for a surface sum of two handlebodies to be a handlebody

The main results of the paper are that we give a necessary and sufficient condition for a surface sum of two handlebodies along a connected surface to be a handlebody as follows:(1)The annulus sum H=H1∪AH2 of two handlebodies H1 and H2 is a handlebody if and only if the core curve of A is a longitude for either H1 or H2;(2)Let H=H1∪Sg,b H2 be a surface sum of two handlebodies H1 and H2 along a connected surface S=Sg,b,b 1,ni=g(Hi)2,i=1,2.Suppose that S is incompressible in both H1 and H2.Then H is a handlebody if and only if there exists a basis J={J1,...,Jm}with a partition(J1,J2)of J such that J1 is primitive in H1 and J2 is primitive in H2.

On 3-Submanifolds of S3 Which Admit Complete Spanning Curve Systems

Let M be a compact connected 3-submanifold of the 3-sphere S^3 with one boundary component F such that there exists a collection of n pairwise disjoint connected orientable surfaces S = {S_1, ···, S_n} properly embedded in M, ?S = {?S_1, ···, ?S_n}is a complete curve system on F. We call S a complete surface system for M, and ?S a complete spanning curve system for M. In the present paper, the authors show that the equivalent classes of complete spanning curve systems for M are unique, that is, any complete spanning curve system for M is equivalent to ?S. As an application of the result,it is shown that the image of the natural homomorphism from the mapping class group M(M) to M(F) is a subgroup of the handlebody subgroup Hn.