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Microsurgery vs. radiosurgery for the treatment of multiple metastases in the brain: a retrospective cohort study 被引量:1
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作者 Qun liu Qiang Yin +3 位作者 Yang Dong fengtong li Wenliang li Xiaoguang Wang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2022年第6期884-892,共9页
Objective:Multiple brain metastases are a severe condition for cancer patients.To date,no general consensus exists regarding the optimal treatment procedure for multiple brain metastases.Radiotherapy is the most commo... Objective:Multiple brain metastases are a severe condition for cancer patients.To date,no general consensus exists regarding the optimal treatment procedure for multiple brain metastases.Radiotherapy is the most commonly used treatment option.The role of surgical resection for multiple brain metastases is unclear.The aim of this study was to compare the outcomes of patients with multiple brain metastases treated with either surgery or stereotactic radiosurgery(SRS).Methods:The medical records of 279 consecutive adult patients with multiple brain metastases treated with either surgery(26 patients)or SRS(253 patients)were retrospectively reviewed.Propensity score matching was conducted to correct for discrepancies in the baseline characteristics,and 78 patients(26 receiving surgery and 52 receiving SRS)were chosen for comparison of outcomes,such as overall survival,local tumor control rate,and symptom improvement.Results:The tumor size in the surgery group was significantly greater than that in the SRS group after propensity score matching.However,the neurological recovery rate,incidence of leptomeningeal metastasis after surgery,1-year local tumor control rate,and overall survival were not significantly different between groups.Conclusions:Our data demonstrate that surgery and radiosurgery have identical overall survival and local tumor control rates in patients with 2 to 4 brain metastases.Although SRS remains the primary and standard option for patients with brain metastasis,surgery offers several distinct advantages,such as establishing a diagnosis or relieving mass effects,and may additionally be beneficial in carefully selected patients with 2–4 brain metastases. 展开更多
关键词 SURGERY RADIOSURGERY brain metastasis THERAPY overall survival
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射波刀治疗脑干转移瘤的疗效与预后分析 被引量:1
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作者 刘群 王晓光 +3 位作者 尹强 董洋 李丰彤 袁智勇 《中国肿瘤临床》 CAS CSCD 北大核心 2019年第19期1003-1007,共5页
目的:评价射波刀治疗脑干转移瘤的疗效和安全性。方法:回顾性分析2013年1月至2018年1月于天津医科大学肿瘤医院接受射波刀治疗的49例患者,共55个脑干转移瘤病灶,总结患者治疗后总生存时间和局部控制率。分析性别、年龄、肿瘤部位、肿瘤... 目的:评价射波刀治疗脑干转移瘤的疗效和安全性。方法:回顾性分析2013年1月至2018年1月于天津医科大学肿瘤医院接受射波刀治疗的49例患者,共55个脑干转移瘤病灶,总结患者治疗后总生存时间和局部控制率。分析性别、年龄、肿瘤部位、肿瘤大小、原发灶病理、KPS评分、术前是否行全脑放疗等对射波刀治疗脑干转移瘤预后的影响。结果:中位肿瘤体积为1.96(0.1~15.6)cm3,总剂量8.0~40.0 Gy,1~5次/d,中位单次等效处方剂量(α/β=10)为18.2(8.0~23.7)Gy。中位最大单次等效剂量为25.2(11.8~37.4)Gy。局部控制率87.3%,15个病灶完全缓解(complete response,CR),27个病灶部分缓解(partial response,PR),6个病灶病变稳定(stable disease,SD)。中位生存时间为14(1~43)个月,中位无进展生存期为17.4个月。治疗后半年、1年、2年的生存率分别为75.5%、55.1%、28.6%。结论:射波刀治疗脑干转移瘤安全有效,射波刀无框架,患者接受度好,分次照射可以用于治疗体积较大的肿瘤,脑干放射性反应发生率低。 展开更多
关键词 射波刀 放射外科 脑干 脑转移 生存时间
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