Online Capacitance Modeling Tool for Conductors Represented as Simply-Connected Polygonal Geometries in 2D

We present an online tool for calculating the capacitance between two conductors represented as simply-connected polygonal geometries in 2D with Dirichlet boundaries and homogeneous dielectric. Our tool can be used to model the so-called 2.5D geometries, where the 3rd dimension can be extruded out of plane. Micro-electro-mechanical systems (MEMS) with significant facing surfaces may be approximated with 2.5D geometry. Our tool compares favorably in accuracy and speed to the finite element method (FEM). We achieve modeling accuracy by treating the corners exactly with a Schwarz-Christoffel mapping. And we achieve fast results by not needing to discretize boundaries and subdomains. As a test case, we model a MEMS torsional actuator. Our tool computes capacitance about 1000 times faster than FEM with 4.7% relative error.

Strategic Measures for Implementing 300 Demonstration Projects to Lead the Construction of Modern Agricultural Industrial Clusters with Output of 100 Billion Yuan

To carefully implement the rural revitalization strategy,further promote the structural reform of the agricultural supply front,implement the "155 Development Strategy",speed up the cultivation of the modern agricultural industrial clusters with output of 100 billion yuan,and constantly consolidate the industrial foundation of the " Second City in Chengdu-Chongqing Line",the Municipal Party Committee and the Municipal Government of Nanchong City decided to implement the " 300 Demonstration Projects" of modern agriculture. It firmly grasps the " bull nose"( key part) of the project,energetically implements the construction of 100 modern circular agricultural demonstration parks,100 agricultural leading enterprises with output value of 100 billion yuan,and 100 agricultural new business model demonstration projects( hereinafter referred to as 300 Demonstration Projects),to realize the goal of the output value of the modern agriculture industrial clusters of Nanchong City exceeds 100 billion yuan in 2020.

Present Situation and Development Countermeasures of Modern Agriculture Industrial Clusters of 100 Billion Output in Nanchong City

Industrial clusters have an obvious role in promoting regional economic development and can enhance region core competitiveness.In order to rapidly promote the economic development of Nanchong,from the aspects of agricultural resources,brand advantages,modern agricultural demonstration zones,deep processing of agricultural products and cold chain logistics,the development status of modern agricultural industrial clusters of 100 billion output in Nanchong City is summarized in this article. For existing problems,resolution strategies are proposed from the aspects of focuses,work paths and safeguards.

First-line camrelizumab(a PD-1 inhibitor)plus apatinib(an VEGFR-2 inhibitor)and chemotherapy for advanced gastric cancer(SPACE):a phase 1 study

Patients with advanced gastric cancer typically face a grim prognosis.This phase 1a(dose escalation)and phase 1b(dose expansion)study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapyfor advanced gastric or gastroesophageal junction adenocarcinoma.The primary endpoints included maximum tolerated dose(MTD)in phase 1a and objective response rate(ORR)across phase 1a and 1b.Phase 1a tested three dose regimens of camrelizumab,apatinib,oxaliplatin,and S-1.Dose regimen 1:camrelizumab 200 mg on day 1,apatinib 250 mg every other day,oxaliplatin 100 mg/m^(2) on day 1,and S-140 mg twice a day on days 1-14.Dose regimen 2:same as dose regimen 1,but oxaliplatin 130mg/m.Dose regimen3:same as dose regimen 2,but apatinib 250 mg daily.Thirty-four patients were included(9 in phase 1a,25 in phase 1b).No dose-limiting toxicities occurred so no MTD was identified.Dose 3 was set for the recommended phase 2 doses and administered in phase 1b.The confrmed ORR was 76.5%(95%CI 58.8-89.3).The median progression-free survival was 8.4 months(95%CI 5.9-not evaluable[NE]),and the median overall survival(OS)was not mature(11.6-NE).Ten patients underwent surgery after treatment and the multidisciplinary team evaluation.Among 24 patients without surgery,the median OS was 19.6 months(7.8-NE).Eighteen patients(52.9%)developed grade≥3 treatment-emergent adverse events.Camrelizumab plus apatinib and chemotherapy showed favorable clinical outcomes and manageable safety for untreated advanced gastric cancer(ChiCTR2000034109).

Main Measures and Achievements in the Development of Organic Agriculture in Nanchong City

In order to improve the quality and efficiency of agriculture,increase farmers'income steadily and rapidly,and improve the ecological environment of agriculture,a strong city of organic agriculture should be constructed in Nanchong City.Based on ecological agriculture,Nanchong makes great efforts to build a strong city of organic agriculture,takes environmental protection supervision as an opportunity to promote sustainable agricultural development feasibly,takes regional brands as the starting point,and promotes the development of agricultural brand.The main measures and achievements of the development of organic agriculture in Nanchong City are analyzed and discussed starting with the next work plan.

Ideas for Accelerating Development of Deep Processing Industry of Agricultural Products--A Case Study of Nanchong City

In order to provide certain references for further deepening the development of processing industry of agricultural products,this paper analyzed and elaborated the basic principles,construction priorities and safeguard measures of the development of deep processing industry of agricultural products in Nanchong City of Sichuan Province. Besides,it made a scientific planning for accelerating the deep processing of agricultural products in Nanchong City in 2018-2020,to ensure the full implementation of fine and deep processing of agricultural products.

Microbiome dysbiosis and alcoholic liver disease

Microbiome dysbiosis is strongly associated with alcoholic liver disease(ALD).Recent studies on comprehensive analyses of microbiome compositional and functional changes have begun to uncover the mechanistic relation between microbiome and the pathogenesis of ALD.Importantly,targeting the microbiome has become a potential strategy for the prevention and treatment of ALD.In this review,we summarize the clinical evidence of microbiome dysbiosis in ALD patients,and experimental advances in microbiome and metabolomic functional changes in animals with different species and genetic backgrounds in ALD.We also summarize the studies in humanized intestinal microbiome and fecal microbiota transplantation in mice.We introduce new developments in the studies on the role of the circulating bacterial microbiome,oral bacterial microbiome and fungal microbiome in the development of ALD.We highlight the potential mechanisms by which microbiome dysbiosis contributes to ALD,including short chain fatty acid changes,bile acid metabolism,intestinal barrier function,release of bacterial and fungal products,and inflammation.In addition,we summarize the recent developments targeting the microbiome in prevention and treatment of ALD,including dietary nutrient interference,herbal medicine,antibiotics,anti-fungal agents,probiotics,engineered bacterial therapy,fecal transplantation and oral hygiene.Although recent preclinical studies have advanced our understanding of the microbiome and ALD,clinical studies,especially prospective studies with large samples,are needed to better understand the cause-effect of microbiome dysbiosis in ALD.Identifying new precision-based strategies targeting the microbiome are expected to be developed as more effective therapies in ALD.©2019 The Third Affiliated Hospital of Sun Yat-sen University.Publishing Services by Elsevier B.V.on behalf of KeAi Communications Co.,Ltd.This is an open access article under the CC BY-NC-ND license.

Thirty-two new species of the genus Speocera Berland, 1914(Araneae: Ochyroceratidae) from China, Madagascar and Southeast Asia

Thirty-two new species of the spider genus Speocera Berland, 1914 from the spider family Ochyroceratidae Fage, 1912 are described from China, Madagascar, and Southeast Asia, namely S. amber Li & Li sp. nov.(♂♀), S. ankalana Li & Li sp. nov.(♂♀), S. bachma Li & Li sp. nov.(♂♀), S. balikpapan Li & Li sp. nov.(♀), S. ballarini Li & Li sp. nov.(♂), S. batang Li & Li sp. nov.(♀), S. bawangling Li & Li sp. nov.(♂♀), S. bontoc Li & Li sp. nov.(♀), S. bukittinggi Li & Li sp. nov.(♂♀), S. cattien Li & Li sp. nov.(♂♀), S. cucphuong Li & Li sp. nov.(♂♀), S. cuyapo Li & Li sp. nov.(♀), S. dongjing Li & Li sp. nov.(♀), S. gexuejuni Li & Li sp. nov.(♂♀), S. griswoldi Li & Li sp. nov.(♀), S. heilan Li & Li sp. nov.(♂♀), S. huifengi Li & Li sp. nov.(♀), S. huisun Li & Li sp. nov.(♀), S. lahrak Li & Li sp. nov.(♂♀), S. longyan Li & Li sp. nov.(♂♀), S. manhao Li & Li sp. nov.(♂♀), S. melinh Li & Li sp. nov.(♀), S. nuichua Li & Li sp. nov.(♂♀), S. payakumbuh Li & Li sp. nov.(♂♀), S. suea Li & Li sp. nov.(♂♀), S. tabuk Li & Li sp. nov.(♀), S. trapezialis Li & Li sp. nov.(♂♀), S. trusmadi Li & Li sp. nov.(♂♀), S. tubularis Li & Li sp. nov.(♂♀), S. xiaoxiaoae Li & Li sp. nov.(♂♀), S. xuanson Li & Li sp. nov.(♂♀), S. zhigangi Li & Li sp. nov.(♂♀). Types of all new species are deposited in the Institute of Zoology, Chinese Academy of Sciences(IZCAS) in Beijing, China and the California Academy of Sciences(CAS) in San Francisco, USA.

Five new genera of the subfamily Psilodercinae(Araneae: Ochyroceratidae) from Southeast Asia

Five new genera of the spider family Ochyroceratidae with remarkable palpal and epigynal characters are described： Luzonacera Li ＆ Li, gen. nov., Qiongocera Li ＆ Li, gen. nov., Relictocera Li ＆ Li, gen. nov., Sinoderces Li ＆ Li, gen. nov., and Thaiderces Li ＆ Li, gen. nov. Six new species are described based on specimens collected in China, Philippines, Vietnam, and Thailand： Luzonacera chang Li ＆ Li, sp. nov., Luzonacera duan Li ＆ Li, sp. nov., Qiongocera hongjunensis Li ＆ Li, sp. nov., Relictocera qiyi Li ＆ Li, sp. nov., Sinoderces nawanensis Li ＆ Li, sp. nov., and Thaiderces jian Li ＆ Li, sp. nov. In addition, two Psiloderces species are transferred to other genera： Sinoderces exilis（Wang ＆ Li, 2013） comb. nov. and Thaiderces vulgaris（Deeleman-Reinhold, 1995） comb. nov. All type specimens are deposited in the Institute of Zoology, Chinese Academy of Sciences（IZCAS） in Beijing.