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Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy:a report of five cases 被引量:1
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作者 Shiping Liu Chenchen Fan +3 位作者 fengzhi feng Yang Xiang Xirun Wan Tong Ren 《Cancer Biology & Medicine》 SCIE CAS CSCD 2017年第2期191-193,共3页
The clinical presentations of gestational choriocarcinoma vary markedly, and a misdiagnosis could be made in atypical patients if simply relying on clinical features. Laparoscopic resection of uterine mass lesion is r... The clinical presentations of gestational choriocarcinoma vary markedly, and a misdiagnosis could be made in atypical patients if simply relying on clinical features. Laparoscopic resection of uterine mass lesion is rarely used in gestational choriocarcinoma diagnosis because of the fear of heavy blood loss and distant metastasis. Five patients who were preoperatively diagnosed as having cornual pregnancy underwent laparoscopic resection of mass lesion and then proved to have gestational choriocarcinoma based on pathological examinations. Chemotherapy was started within two days after surgery, and the rate of complete remission was 100%. The mean follow-up time was 29.8±19.1 months, and no patient showed signs of relapse. Laparoscopic resection of uterine mass followed by timely postoperative chemotherapy may be an effective and safe way to obtain pathologic results in patients with suspected gestational choriocarcinoma. 展开更多
关键词 诊断过程 腹腔镜 妊娠 病理学检查 子宫切除术 预后 临床表现
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家族性子宫肌瘤相关VEGFR1胚系突变对mTOR抑制剂敏感 被引量:1
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作者 戴毓欣 张馨宇 +5 位作者 吕佳蕊 冯凤芝 万希润 黄富强 张宏冰 朱兰 《Science Bulletin》 SCIE EI CSCD 2022年第6期585-587,M0003,共4页
子宫肌瘤是女性生殖道系统最为常见的良性肿瘤,目前其发病机制尚不明确.本研究通过对一个多发性子宫肌瘤家系全外显子测序研究,发现了血管内皮生长因子受体1(VEGFR1)中P801Q的杂合胚系突变.该突变位于VEGFR1的近膜结构(JM)域,通过3D同... 子宫肌瘤是女性生殖道系统最为常见的良性肿瘤,目前其发病机制尚不明确.本研究通过对一个多发性子宫肌瘤家系全外显子测序研究,发现了血管内皮生长因子受体1(VEGFR1)中P801Q的杂合胚系突变.该突变位于VEGFR1的近膜结构(JM)域,通过3D同源性建模预测该突变会损害JM区域的自抑制功能.此外,该突变体激活了培养细胞和肌瘤样本中的mTOR信号和MAPK信号通路.mTOR抑制剂雷帕霉素(西罗莫司)和MAPK抑制剂曲美替尼优先抑制VEGFR1P801Q表达细胞的增殖,家系先证者术后参加了西罗莫司预防肿瘤复发的临床试验,应用西罗莫司2年无复发,且无明显不良反应.综上,本研究揭示了VEGFR1介导的mTOR和MAPK信号通路在家族性子宫肌瘤发生中的关键作用.鉴于mTOR抑制剂有治疗子宫肌瘤和保留生育功能的潜力,雷帕霉素有望靶向治疗部分子宫肌瘤病人. 展开更多
关键词 MTOR抑制剂 先证者 西罗莫司 女性生殖道 雷帕霉素 胚系突变 子宫肌瘤 临床试验
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