Introduction. Epithelioid hemangioendothelioma is a tumor of soft tissues aris ing from the vascular endothelium. It is considered as a low-grade malignant tu mor. Cutaneous involvement is rare and often associated wi...Introduction. Epithelioid hemangioendothelioma is a tumor of soft tissues aris ing from the vascular endothelium. It is considered as a low-grade malignant tu mor. Cutaneous involvement is rare and often associated with multi-systemic loc alizations. Case report. We report the case of a 34 year-old woman with a 6-mo nth history of a 1.5 cm erythematous-violaceous, soft, painful cutaneous nodule involving the right forearm. An abdominal sonography had been performed 1 month before the onset of the nodule, because of epigastric pain and was normal. Hist ological and immunohistological examinations led to diagnosis of an epithelioid hemangioendothelioma. Assessment of the extension with radiology, sonography, to modensitometry and magnetic resonance imaging, revealed nodules of the liver. Tr eatment consisted in the wide and complete excision of the tumor. There was no e vidence of local recurrence after one year follow-up, and the hepatic lesions w ere stable. Discussion. Epithelioid hemangioendotheliomas belong to the epitheli oid vascular tumor spectrum. They have in common the morphologic epithelioid asp ect of endothelial tumor cells. Cutaneouslocalizationisrare,andtothebestofourkno wledge, only 20 cases of epithelioid hemangioendothelioma with skin involvement have been reported in the literature. Epithelioid hemangioendotheliomacanbe isol atedorassociatedwithinternal visceral involvement. The detection of skin lesions should lead to a complete assessment of the extension of the disease to detect any internal localization. Because of low-grade malignancy of the tumor, and th e integrity of the liver observed one month before the onset of the disease in o ur patient, epithelioid hemangioendothelioma appears to be a multicentric diseas e rather than metastatic hepatic localizations of a primitive skin cancer.展开更多
Lymphoepithelioma-like carcinoma of the skin (LELCs) is a rare cutaneous neoplasm with histologic features resembling lymphoepitheliomatous tumors of the nasopharynx. The association of lymphoepitheliomas with Epstein...Lymphoepithelioma-like carcinoma of the skin (LELCs) is a rare cutaneous neoplasm with histologic features resembling lymphoepitheliomatous tumors of the nasopharynx. The association of lymphoepitheliomas with Epstein-Barr Virus (EBV) at some extracutaneous sites is well documented. In contrast, the presence of EBV in LELCs has never been shown in either Caucasians or Asian patients. We present the first case of LELCs in a Tunisian patient, a 78-year-old woman who presented with a nodule of the right cheek of 2 months’duration. The patient underwent surgical excision and there was no evidence of local recurrence 6 months later. Histologically, the entire dermis was occupied by lobules composed of atypical epithelial cells surrounded by a dense lymphoplasmacytic infiltrate. Immunohistochemical examination showed that the epithelial tumor cells were positive for cytokeratin and epithelial membrane antigen. In situ hybridization investigations for the presence of EBV-encoded RNA showed negative results. Our findings suggest that LELCs is not related to EBV among North African patients.展开更多
文摘Introduction. Epithelioid hemangioendothelioma is a tumor of soft tissues aris ing from the vascular endothelium. It is considered as a low-grade malignant tu mor. Cutaneous involvement is rare and often associated with multi-systemic loc alizations. Case report. We report the case of a 34 year-old woman with a 6-mo nth history of a 1.5 cm erythematous-violaceous, soft, painful cutaneous nodule involving the right forearm. An abdominal sonography had been performed 1 month before the onset of the nodule, because of epigastric pain and was normal. Hist ological and immunohistological examinations led to diagnosis of an epithelioid hemangioendothelioma. Assessment of the extension with radiology, sonography, to modensitometry and magnetic resonance imaging, revealed nodules of the liver. Tr eatment consisted in the wide and complete excision of the tumor. There was no e vidence of local recurrence after one year follow-up, and the hepatic lesions w ere stable. Discussion. Epithelioid hemangioendotheliomas belong to the epitheli oid vascular tumor spectrum. They have in common the morphologic epithelioid asp ect of endothelial tumor cells. Cutaneouslocalizationisrare,andtothebestofourkno wledge, only 20 cases of epithelioid hemangioendothelioma with skin involvement have been reported in the literature. Epithelioid hemangioendotheliomacanbe isol atedorassociatedwithinternal visceral involvement. The detection of skin lesions should lead to a complete assessment of the extension of the disease to detect any internal localization. Because of low-grade malignancy of the tumor, and th e integrity of the liver observed one month before the onset of the disease in o ur patient, epithelioid hemangioendothelioma appears to be a multicentric diseas e rather than metastatic hepatic localizations of a primitive skin cancer.
文摘Lymphoepithelioma-like carcinoma of the skin (LELCs) is a rare cutaneous neoplasm with histologic features resembling lymphoepitheliomatous tumors of the nasopharynx. The association of lymphoepitheliomas with Epstein-Barr Virus (EBV) at some extracutaneous sites is well documented. In contrast, the presence of EBV in LELCs has never been shown in either Caucasians or Asian patients. We present the first case of LELCs in a Tunisian patient, a 78-year-old woman who presented with a nodule of the right cheek of 2 months’duration. The patient underwent surgical excision and there was no evidence of local recurrence 6 months later. Histologically, the entire dermis was occupied by lobules composed of atypical epithelial cells surrounded by a dense lymphoplasmacytic infiltrate. Immunohistochemical examination showed that the epithelial tumor cells were positive for cytokeratin and epithelial membrane antigen. In situ hybridization investigations for the presence of EBV-encoded RNA showed negative results. Our findings suggest that LELCs is not related to EBV among North African patients.
