Objective: Previous studies did not establish a clear correlation between the presence of endometriosis and the values of body mass index (BMI). Study design: The BMI of 366 women with endometriosis was compared to th...Objective: Previous studies did not establish a clear correlation between the presence of endometriosis and the values of body mass index (BMI). Study design: The BMI of 366 women with endometriosis was compared to that of 248 controls undergoing laparoscopy because of benign gynaecological conditions. Significant differences at univariate analyses were confirmed by using Analysis of covariance (ANCOVA) to control for potential confounding variables. Results: BMI was significantly lower in women with endometriosis than in controls (p < 0.001); this difference was confirmed when the analysis was restricted to subjects with normal BMI (18.50-24.99 kg/m2) (p = 0.002). 4.8% of control subjects and no woman with endometriosis were obese. No significant difference was observed in the BMI of women with mild (revised classification of the American Fertility Society, rAFS Ⅰ -Ⅱ ) and severe endometriosis (rAFS Ⅲ -Ⅳ ). Conclusion: Women with endometriosis have lower BMI and are less frequently obese than control subjects. Further studies should investigate the physiopathological basis of decreased BMI in women with endometriosis.展开更多
Objective: To estimate the expression of haptoglobin (Hp)-βchain isoforms in the peritoneal fluid (PF) and plasma (PL) of women with and without endometrios is. Design: Cross-sectional study. Setting: University hosp...Objective: To estimate the expression of haptoglobin (Hp)-βchain isoforms in the peritoneal fluid (PF) and plasma (PL) of women with and without endometrios is. Design: Cross-sectional study. Setting: University hospital. Patient(s): Se venty-two patients with endometriosis and 35 controls. Intervention(s): Periton eal fluid and PL samples were subjected to two-dimensional gel electrophoresis, silver stained, digitally captured, and compared by semiquantitative computeriz ed analysis. Main Outcome Measure(s): Expression of Hp βchain isoforms. Result( s): No significant difference was observed in the frequency of expression of the Hp βchain isoforms between the two groups. One βchain isoform (HpβE; molecul ar weight, 38.40 ±0.94 kD; and isoelectric point, 5.63 ±0.17) had significantl y higher expression in both the PF and PL of women with endometriosis than in th e PF and PL of controls. No significant difference was observed in HpβE express ion between women with mild (revised American Fertility Society [rAFS], stage I -II) and severe (rAFS, stage III-IV) endometriosis. In the control group, Hpβ E expression was correlated with the phase of the menstrual cycle. Conclusion(s) : Women with endometriosis have higher PF and PL levels of HpβE. Further invest igation should be aimed at producing antibodies against the HpβE-specific epit opes to determine whether its measurement may improve the clinical diagnosis of endometriosis.展开更多
文摘Objective: Previous studies did not establish a clear correlation between the presence of endometriosis and the values of body mass index (BMI). Study design: The BMI of 366 women with endometriosis was compared to that of 248 controls undergoing laparoscopy because of benign gynaecological conditions. Significant differences at univariate analyses were confirmed by using Analysis of covariance (ANCOVA) to control for potential confounding variables. Results: BMI was significantly lower in women with endometriosis than in controls (p < 0.001); this difference was confirmed when the analysis was restricted to subjects with normal BMI (18.50-24.99 kg/m2) (p = 0.002). 4.8% of control subjects and no woman with endometriosis were obese. No significant difference was observed in the BMI of women with mild (revised classification of the American Fertility Society, rAFS Ⅰ -Ⅱ ) and severe endometriosis (rAFS Ⅲ -Ⅳ ). Conclusion: Women with endometriosis have lower BMI and are less frequently obese than control subjects. Further studies should investigate the physiopathological basis of decreased BMI in women with endometriosis.
文摘Objective: To estimate the expression of haptoglobin (Hp)-βchain isoforms in the peritoneal fluid (PF) and plasma (PL) of women with and without endometrios is. Design: Cross-sectional study. Setting: University hospital. Patient(s): Se venty-two patients with endometriosis and 35 controls. Intervention(s): Periton eal fluid and PL samples were subjected to two-dimensional gel electrophoresis, silver stained, digitally captured, and compared by semiquantitative computeriz ed analysis. Main Outcome Measure(s): Expression of Hp βchain isoforms. Result( s): No significant difference was observed in the frequency of expression of the Hp βchain isoforms between the two groups. One βchain isoform (HpβE; molecul ar weight, 38.40 ±0.94 kD; and isoelectric point, 5.63 ±0.17) had significantl y higher expression in both the PF and PL of women with endometriosis than in th e PF and PL of controls. No significant difference was observed in HpβE express ion between women with mild (revised American Fertility Society [rAFS], stage I -II) and severe (rAFS, stage III-IV) endometriosis. In the control group, Hpβ E expression was correlated with the phase of the menstrual cycle. Conclusion(s) : Women with endometriosis have higher PF and PL levels of HpβE. Further invest igation should be aimed at producing antibodies against the HpβE-specific epit opes to determine whether its measurement may improve the clinical diagnosis of endometriosis.
