目的:研究9,10-二甲基-1,2-苯并蒽(9,10-dimethyl-1,2-benzanthracene,DMBA)以及蜂胶乙醇提取物(ethanol extract of propolis,EPE)对金仓鼠舌黏膜组织反应的影响。方法:60只金仓鼠按实验周期被随机分为两大组,每组再被分为EPE组、蜂胶...目的:研究9,10-二甲基-1,2-苯并蒽(9,10-dimethyl-1,2-benzanthracene,DMBA)以及蜂胶乙醇提取物(ethanol extract of propolis,EPE)对金仓鼠舌黏膜组织反应的影响。方法:60只金仓鼠按实验周期被随机分为两大组,每组再被分为EPE组、蜂胶水提取物(aqueous propolis extract,APE)组和DMBA组(n=20)。测定实验鼠舌黏膜的临床和组织学改变,包括面积、容积的临床改变,鳞状上皮组织的结构和细胞学变化,并测量鳞状细胞癌组织学上的改变区域。结果:各组在第13周和第20周所测定的实验结果不存在显著差异。在第13周,EPE组出现1例单一鳞状细胞癌;在第20周,EPE组的鳞状细胞癌的发生率最高,但与其他组比较差异无统计学意义。结论:蜂胶乙醇提取物对舌黏膜组织的影响以及其致癌机制还有待研究。展开更多
Dental caries, the disease that causes tooth decay, is infectious, and the mutans streptococci bacteria have long been identified as the primary disease-causing agents. Caries vaccines showed promising results in expe...Dental caries, the disease that causes tooth decay, is infectious, and the mutans streptococci bacteria have long been identified as the primary disease-causing agents. Caries vaccines showed promising results in experimental studies;however, it remains far the effective use in humans due to political-economic and ethical issues. Progress towards practical vaccine development requires evaluation of candidate vaccines in clinical trials. Promising strategies of passive immunization also require further clinical evaluation. The purpose of this chapter is to review the literature on the main research projects aimed at developing caries vaccines.展开更多
文摘Dental caries, the disease that causes tooth decay, is infectious, and the mutans streptococci bacteria have long been identified as the primary disease-causing agents. Caries vaccines showed promising results in experimental studies;however, it remains far the effective use in humans due to political-economic and ethical issues. Progress towards practical vaccine development requires evaluation of candidate vaccines in clinical trials. Promising strategies of passive immunization also require further clinical evaluation. The purpose of this chapter is to review the literature on the main research projects aimed at developing caries vaccines.
